A5068417665- Tissue Engineering and Regenerative Medicine
- 3D Printing in Biomedical Research
- Electrospun Nanofibers in Biomedical Applications
- Pluripotent Stem Cells Research
- Cardiac Imaging and Diagnostics
- Advanced Sensor and Energy Harvesting Materials
- Neuroscience and Neural Engineering
- Atrial Fibrillation Management and Outcomes
- Congenital heart defects research
- Additive Manufacturing and 3D Printing Technologies
- Cardiovascular Function and Risk Factors
Mayo Clinic in Arizona
2024
Arizona State University
2020-2024
Tempe Union High School District
2020
Electrically conductive biomaterials and nanomaterials have demonstrated great potential in the development of functional mature cardiac tissues. In particular, gold emerged as promising candidates due to their biocompatibility ease fabrication for tissue engineering utilizing rat- or stem cell-derived cardiomyocytes (CMs). However, despite significant advancements, it is still not clear whether enhancement function primarily electroconductivity features nanoparticles structural changes...
The prevalence of cardiovascular risk factors is expected to increase the occurrence diseases (CVDs) worldwide. Cardiac organoids are promising candidates for bridging gap between in vitro experimentation and translational applications drug development cardiac repair due their attractive features. Here we present fabrication characterization isogenic scaffold-free derived from human induced pluripotent stem cells (hiPSCs) formed under a supplement-deprivation regimen that allows metabolic...
Cardiac tissue engineering is an emerging field providing tools to treat and study cardiovascular diseases (CVDs). In the past years, integration of stem cell technologies with micro- nanoengineering techniques has enabled creation novel engineered cardiac tissues (ECTs) potential applications in disease modeling, drug screening, regenerative medicine. However, a major unaddressed limitation cell-derived ECTs their immature state, resembling neonatal phenotype genotype. The modulation...
Acute atrial ischemia is a well-known cause of postoperative fibrillation (POAF). However, mechanisms through which contributes to the development POAF are not well understood. In this study, ex vivo Langendorff perfusion was used induce acute and reperfusion in heart order mimic POAF. Inducibility (AF) evaluated using programmed electrical stimulation confirmed with open-atrium optical mapping. Compared control group without ischemia, 25 minutes substantially increased incidence AF. The...
In this paper, we report the development of a wireless, passive, biocompatible, and flexible system for stimulation human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMS). Fabricated on transparent parylene/PDMS substrate, proposed stimulator enables real-time excitation characterization hiPSC-CMs cultured on-board. The device comprises rectenna operating at 2.35 GHz which receives radio frequency (RF) energy from an external transmitter converts it into DC voltage to deliver...
Electrically conductive biomaterials and nanomaterials have demonstrated a great potential in the development of functional mature cardiac tissues. In particular, gold emerged as promising candidates due to their biocompatibility ease fabrication for tissue engineering, utilizing rat- or stem cell-derived cardiomyocytes (CMs). Among various cell types, human induced pluripotent (hiPSC-CMs) unique source engineering tissues, serving range applications from vitro disease modeling vivo heart...