A5059797034- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- 3D Printing in Biomedical Research
- PI3K/AKT/mTOR signaling in cancer
- Primary Care and Health Outcomes
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Genetic factors in colorectal cancer
- Wound Healing and Treatments
- Molecular Junctions and Nanostructures
- Nail Diseases and Treatments
- Economic Sanctions and International Relations
- Cancer and Skin Lesions
- thermodynamics and calorimetric analyses
- Chemical Synthesis and Analysis
- Cell Adhesion Molecules Research
- Musicology and Musical Analysis
- Corneal Surgery and Treatments
- Quinazolinone synthesis and applications
- Epigenetics and DNA Methylation
- Nonmelanoma Skin Cancer Studies
- Glycosylation and Glycoproteins Research
- Ubiquitin and proteasome pathways
- Cancer-related gene regulation
- Electrochemical Analysis and Applications
Arizona State University
2022-2024
Wake Forest University
2016-2019
Forest Institute
2019
Winthrop University
2011-2015
Vanderbilt University
2004
Electrically conductive biomaterials and nanomaterials have demonstrated great potential in the development of functional mature cardiac tissues. In particular, gold emerged as promising candidates due to their biocompatibility ease fabrication for tissue engineering utilizing rat- or stem cell-derived cardiomyocytes (CMs). However, despite significant advancements, it is still not clear whether enhancement function primarily electroconductivity features nanoparticles structural changes...
There is a need for effective wound treatments that retain the bioactivity of cellular treatment, but without high costs and complexities associated with manufacturing, storing, applying living biological products. Previously, we developed an amnion membrane-derived hydrogel evaluated its healing properties using mouse model. In this study, used full thickness porcine skin model to evaluate wound-healing efficacy less-processed product comprising lyophilized membrane powder. These products...
Abstract The focal adhesion kinase (FAK) scaffold provides FAK-targeted cancer therapeutics with greater efficacy and specificity than traditional inhibitors. FAK function largely involves the interaction between FAK’s targeting (FAT) domain paxillin, ultimately regulating many hallmarks of cancer. We report design paxillin LD-motif mimetics that successfully inhibit FAT-paxillin interaction. Chemical biochemical screening identifies stapled peptide 1907, a high affinity binder FAT...
High‐mobility group A1 ( HMGA1 ) encodes proteins that act as mediators in viral integration, modification of chromatin structure, neoplastic transformation and metastatic progression. Because is overexpressed most cancers has transcriptional relationships with several Wnt‐responsive genes, we explored the involvement Wnt/β‐catenin/TCF‐4 signalling. In adenomatous polyposis coli APC Min/+ mice, observed significant up‐regulation mRNA protein intestinal tumours when compared normal mucosa....
A number of new substituted morpholinopyrimidines were prepared utilizing sequential nucleophilic aromatic substitution and cross-coupling reactions. One the disubstituted pyrimidines was converted into two trisubstituted compounds which screened as PI3K inhibitors relative to well-characterized inhibitor ZSTK474, found be 1.5⁻3-times more potent. leucine linker attached most active since it would remain on any peptide-containing prodrug after cleavage by prostate-specific antigen, did not...
A number of new trisubstituted triazine phosphatidylinositol 3-kinase (PI3K) inhibitors were prepared via a three-step procedure utilizing sequential nucleophilic aromatic substitution and cross-coupling reactions. All screened as PI3K relative to the well-characterized inhibitor, ZSTK474. The most active here 2⁻4 times more potent than leucine linker was attached inhibitor since it would remain on any peptide-containing prodrug after cleavage by prostate-specific antigen, did not prevent...
Aberrant expression of high mobility group A1 (hmga1), resulting from inactivating defects in upstream tumor suppressor genes or upregulation oncogenic transactivators, induces the initiation cancer progression pathways. The protein products hmga1, HMGA1a and HMGA1b, are characterized by presence three DNA-binding motifs that possess a central RGR sequence preferentially bind to minor-groove AT-rich stretches target DNA. Importantly, R25 within first motif bears covalent modifications may...
The PI3K/Akt pathway is one of the most frequently dysregulated signaling pathways in cancer and remains a crucial target drug development. Current therapeutic drugs are potent, but often lack cellular specificity needed to lower toxicity effects. Here we show design synthesis two types novel PSA‐activated PI3K inhibitors for treatment androgen‐independent prostate cancer. Both literature predictive molecular modeling studies suggest enzyme inhibition nanomolar/picomolar range. Type 1...
High Mobility Group A1 (HMGA1) encodes proteins that act as mediators in viral integration, modification of chromatin structure, neoplastic transformation, and metastatic progression. Because HMGA1 is overexpressed most cancers has transcriptional relationships with several Wnt‐responsive genes, we explored the involvement Wnt/β‐catenin/TCF‐4 signaling. In adenomatous polyposis coli (APCMin/+) mice, observed significant upregulation mRNA protein intestinal tumors when compared to normal...
Electrically conductive biomaterials and nanomaterials have demonstrated a great potential in the development of functional mature cardiac tissues. In particular, gold emerged as promising candidates due to their biocompatibility ease fabrication for tissue engineering, utilizing rat- or stem cell-derived cardiomyocytes (CMs). Among various cell types, human induced pluripotent (hiPSC-CMs) unique source engineering tissues, serving range applications from vitro disease modeling vivo heart...