A5108659867- Skin Protection and Aging
- Cutaneous Melanoma Detection and Management
- Cell Adhesion Molecules Research
- Cancer Treatment and Pharmacology
- Melanoma and MAPK Pathways
- BRCA gene mutations in cancer
- Metabolism, Diabetes, and Cancer
- Management of metastatic bone disease
- Ubiquitin and proteasome pathways
- Facial Nerve Paralysis Treatment and Research
- Cellular Mechanics and Interactions
- Air Quality and Health Impacts
- melanin and skin pigmentation
- Cancer Mechanisms and Therapy
- Intraoperative Neuromonitoring and Anesthetic Effects
- Advanced Breast Cancer Therapies
- Glycosylation and Glycoproteins Research
- Head and Neck Cancer Studies
- Cancer Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- Meningioma and schwannoma management
- Occupational Therapy Practice and Research
- Perfectionism, Procrastination, Anxiety Studies
- Childhood Cancer Survivors' Quality of Life
- Coffee research and impacts
University of Arizona
2019-2025
Université de Sherbrooke
2025
NYU Langone Health
2024
Tulane University
2021-2023
University of Arizona Cancer Center
2019
Memorial Sloan Kettering Cancer Center
2015-2016
Harvard University
2013-2016
New York University
2012
New York Proton Center
2011
Abstract The focal adhesion kinase (FAK) scaffold provides FAK-targeted cancer therapeutics with greater efficacy and specificity than traditional inhibitors. FAK function largely involves the interaction between FAK’s targeting (FAT) domain paxillin, ultimately regulating many hallmarks of cancer. We report design paxillin LD-motif mimetics that successfully inhibit FAT-paxillin interaction. Chemical biochemical screening identifies stapled peptide 1907, a high affinity binder FAT...
Background: Superior cluneal neuropathy (SCN) is an under-recognized source of unilateral low back and buttock pain, representing approximately 14% lower pain cases. The condition caused by entrapment or irritation the superior nerves. Diagnosis challenging due to symptom overlap with other spinal pelvic conditions absence gold-standard diagnostic criteria. Objective: This case series evaluates utility ultrasound (US) guidance combined nerve stimulation for diagnosing treating SCN,...
Abstract Background: Alcohol consumption is associated with increased risk of numerous cancers, but existing evidence for an association melanoma equivocal. No study has evaluated the different anatomic locations melanoma. Methods: We used data from three large prospective cohort studies to investigate whether alcohol intake was assessed repeatedly by food-frequency questionnaires. A Cox proportional hazards model calculate multivariate-adjusted hazard ratios (HRs). Results: total 1,374...
Focal Adhesion Kinase (FAK) is a major cancer drug target that involved in numerous aspects of tumor progression and survival. While multiple research groups have developed ATP-competitive small molecule inhibitors the kinase enzyme, recent attention has been focused on FAK FERM (Band 4.1, Ezrin, Radixin, Moesin) domain contains key residue Y397 contributes to many protein-protein interactions. Previous x-ray crystal structures gave conflicting results structure region therefore overall...
<b>Objective</b> To determine whether transcranial motor-evoked potential (TCMEP) monitoring of the facial nerve (FN) during cerebellopontine angle (CPA) tumor resection can predict both immediate and long-term postoperative FN function. <b>Design</b> Retrospective review. <b>Setting</b> Tertiary referral center. <b>Main Outcome Measures</b> DeltaTCMEP (final-initial) function using House Brackmann (HB) rating scale. <b>Results</b> Intraoperative TCMEP data follow-up outcome are reported for...
The Focal Adhesion Targeting (FAT) domain of Kinase (FAK) is a promising drug target since FAK overexpressed in many malignancies and promotes cancer cell metastasis. FAT serves as scaffolding protein, its interaction with the protein paxillin localizes to focal adhesions. Various studies have highlighted importance FAT-paxillin binding tumor growth, invasion, this through high-throughput screening (HTS) provides challenge due large complex interface. In report, we describe novel approach...
Entry-level clinical doctorate degrees are becoming more prevalent in the United States for occupational therapy. As indicated by Accreditation Council Occupational Therapy Education® standards, doctoral capstone is an essential component to entry-level degree. Despite importance of capstone, there have been limited publications about development, implementation, and evaluation. A retrospective review was completed on qualitative descriptive data from a national electronic survey therapy...
Focal adhesion kinase (FAK) is a promising cancer drug target due to its massive overexpression in multiple solid tumors and critical role the integration of signals that control proliferation, invasion, apoptosis, metastasis. Previous FAK discovery high-throughput screening have exclusively focused on identification inhibitors domain FAK. Because both scaffolding protein, development novel assays detect protein–protein interactions remains need. In this report, we describe fluorescence...
Background: Intraoperative monitoring of the facial nerve (FN) by continuous electromyography (EMG) and direct stimulation is routine has been shown to improve FN outcome during cranial base surgery. However, requires identification implies functional integrity only between site recording electrodes. In contrast, motor-evoked potential (MEP) using transcranial motor cortex does not require yields information regarding full pathway. This novel method initial utility in surgery skull tumors...
Over the past several decades, incidence of melanoma has risen dramatically in Caucasian populations worldwide. The potential reasons for this increase are many, but concomitant explosion indoor tanning since early 1980s drawn particular scrutiny from scientists, professional societies and legislators. Ample evidence now demonstrates that significantly increases an individual's risk developing both nonmelanoma skin cancers. Other explanations increasing rate diagnosis, including increased...
582 Background: Resistance to HER2 antagonism in HER2-positive breast cancer has been associated with activation of the PI3K signaling pathway. PIK3CA mutations exon 9 and 20 have shown activate AKT-mTOR pathway downstream EGFR-family receptor tyrosine kinases, where most targeted drugs for exert their effect. Methods: We measured mutation status exons (E545K E542K) (H1047R) using two different methods [pyrosequencing (Monogram) an allele-specific, real-time PCR assay (D×S)] correlated...
<div>Abstract<p><b>Background:</b> Alcohol consumption is associated with increased risk of numerous cancers, but existing evidence for an association melanoma equivocal. No study has evaluated the different anatomic locations melanoma.</p><p><b>Methods:</b> We used data from three large prospective cohort studies to investigate whether alcohol intake was melanoma. assessed repeatedly by food-frequency questionnaires. A Cox proportional hazards...