A5030697224- Analytical Chemistry and Sensors
- Advanced biosensing and bioanalysis techniques
- Electrochemical Analysis and Applications
- Electrochemical sensors and biosensors
- Molecular Junctions and Nanostructures
- Nanowire Synthesis and Applications
- Conducting polymers and applications
- Neuroscience and Neural Engineering
- Advanced Biosensing Techniques and Applications
- Analytical chemistry methods development
- Advanced Sensor and Energy Harvesting Materials
- Microfluidic and Capillary Electrophoresis Applications
- Semiconductor materials and devices
- Intermetallics and Advanced Alloy Properties
- Biosensors and Analytical Detection
- Advancements in Semiconductor Devices and Circuit Design
- Microfluidic and Bio-sensing Technologies
- Force Microscopy Techniques and Applications
- Gas Sensing Nanomaterials and Sensors
- Microstructure and mechanical properties
- 3D Printing in Biomedical Research
- Thin-Film Transistor Technologies
- Polymer Surface Interaction Studies
- Spectroscopy and Quantum Chemical Studies
- Magnetic properties of thin films
The University of Tokyo
2016-2025
Bunkyo University
2018
Japan Science and Technology Agency
2014
NanoBio (United States)
2009-2010
National Institute for Materials Science
2003-2009
Material (Belgium)
1993-2007
Osaka University
1999-2003
Materials Science & Engineering
2001
Tsumura Research Institute (Japan)
1999
Jefferson College
1995
Biosensors based on field-effect transistors (FETs) are suitable for use in miniaturized and cost-effective healthcare devices. Various semiconductive materials can be applied as FET channels biosensing, including one- two-dimensional materials. The signal transduction interface between the biosample channel of FETs plays a key role translating electrochemical reactions into output signals, thereby capturing target ions or biomolecules. In this Review, distinctive interfaces biosensors...
We have been developing a genetic field-effect transistor (FET) based on the potentiometric detection of hybridization and intercalation Si 3 N 4 gate insulator. In this study, we demonstrated charge density change as result using FETs. Since electrical output signal is obtained with FET without any labeling reagent, compared conventional fluorescence-based DNA chips, platform suitable for simple inexpensive system analysis in clinical diagnostics.
In charge: Label-free DNA sequencing can be performed by using a field-effect transistor to detect the intrinsic molecular charges (see picture). Oligonucleotide probes are immobilized on Si3N4 gate surface, and complementary target is hybridized with them. The change in charge density Si3N4/SiO2 caused each single-base extension measured as shift threshold voltage. VG=gate
Abstract Aims/Introduction To prevent diabetic complications, strict glucose control and frequent monitoring of blood levels with invasive methods are necessary. We considered the tear might be a possible method for non‐invasive monitoring. develop clinical application, we investigated precise correlation between concentrations. Materials Methods A total 10 participants 20 diabetes were admitted, samples collected. Before statistical analysis, eliminated contaminated blood. observed daily...
Potentiometric measurement of allele-specific oligonucleotide hybridization based on the principle detection charge-density change at surface a gate insulator by using genetic field-effect transistor has been demonstrated. Since DNA molecules are negatively charged in aqueous solution, event leads to channel FET and can be directly transduced into an electrical signal without any labeling target molecules. One unique features our method is utilize binders such as intercalators species for...
In this paper, we propose a highly sensitive and biocompatible glucose sensor using semiconductor-based field effect transistor (FET) with functionalized hydrogel. The principle of the FET device contributes to easy detection ionic charges high sensitivity, hydrogel coated on electrode enables specific biocompatibility. copolymerized Au gate is optimized by controlling mixture ratio 2-hydroxyethylmethacrylate (HEMA) as main monomer vinylphenylboronic acid (VPBA) glucose-responsive monomer....
We demonstrated the live monitoring of cellular respiration using an ion-sensitive field-effect transistor (ISFET), focusing on different types living cells, namely cancer and normal cells. In particular, we realized label-free, real-time, noninvasive microenvironmental pH behavior based extracellular acidosis around cells in long term situ. The change interfacial (ΔpHint), which was analyzed potential (Δ Vout) at cell/gate nanogap interface gradually decreased for every cell-based ISFET....
In this paper, we proposed to enhance a signal-to-noise (S/N) ratio for detecting primary stress marker, serotonin, using potentiometric biosensor modified by well-designed nanofilter film. An extended-Au-gate field-effect transistor (EG-Au-gate FET) exhibits highly sensitive electrochemical detection toward various small biomolecules, including serotonin. Therefore, the S/N serotonin detection, designed an appropriate film on Au electrode combining aryldiazonium salt reduction strategy and...
In this study, we proposed a new detection method, open sandwich-based immuno-field effect transistor (OS-FET) for label-free and noncompetitive of low molecular weight antigen. The principle OS-FET is based on the intrinsic charges caused by small antigen-dependent interchain interaction separated VL VH chains from single antibody variable region using field effect. Introducing chain antigen bisphenol A into with immobilized gate, could detect electrically directly binding chains. Although...
In this study, we have proposed and demonstrated experimentally a novel monitoring device of single mouse embryo activity after in vitro fertilization (IVF) using semiconductor-based field effect transistor (FET). The FET biosensor realized to detect it noninvasively, quantitatively, continuously by change hydrogen ions with positive charges, which were induced dissolved carbon dioxide due cellular respiration during cleavage. electrical signal should become an effective indication evaluate...
A platform based on a highly selective and sensitive detection device functionalized with well-designed artificial biointerface is required for versatile biosensors. We develop molecularly imprinted polymer (MIP)-coated gate field-effect transistor (FET) biosensor low-concentration glucose in biological fluid samples such as tears an enzyme-free manner. The MIP includes templates (GluMIP), which binds to vinylphenylboronic acid the copolymerized membrane, resulting change density of...
A paper-based electrode is a very attractive component for disposable, nontoxic, and flexible biosensor. In particular, wearable biosensors, which have recently been attracting interest, not only require these characteristics of electrodes but must also be able to detect various ions biomolecules in biological fluids. this paper, we demonstrate the detection ability metal biosensors as part wireless potentiometric measurement system, focusing on pH sodium ions. The were obtained by simply...
Cortisol is a major stress biomarker involved in the regulation of metabolic and immune responses. Readily accessible assays with sufficient quantitative temporal resolution can assist prevention, early diagnosis, management chronic diseases. Whereas conventional are costly terms time, labor, capital, an electrochemical approach offers possibility miniaturization detection at point-of-care. Here, we investigate biosensor application molecularly imprinted polypyrrole (PPy) doped...
Rapid and sensitive detection of virus-related antigens antibodies is crucial for controlling sudden seasonal epidemics monitoring neutralizing antibody levels after vaccination. However, conventional methods still face challenges related to compatibility with rapid, highly sensitive, compact apparatus. In this work, we developed a Si nanowire (SiNW)-based field-effect biosensor by precisely the process conditions achieve required electrical properties via complementary...
We proposed an interface molecule for immobilization of DNA probes on solid substrates chips. have designed and synthesized tripodal thiol derivatives stable oligonucleotide a gold surface. On the basis tetrahedral structure tripod, were bonded upright to substrate, which would control orientation probes. When substrate with tethered using was exposed deionized water at higher temperatures, molecules attached surface more stably than single contact molecules. The chip platform combined...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSemiconductor effect on the selective photocatalytic reaction of .alpha.-hydroxycarboxylic acidsH. Harada, T. Sakata, and UedaCite this: J. Phys. Chem. 1989, 93, 4, 1542–1548Publication Date (Print):February 1, 1989Publication History Published online1 May 2002Published inissue 1 February 1989https://pubs.acs.org/doi/10.1021/j100341a070https://doi.org/10.1021/j100341a070research-articleACS PublicationsRequest reuse permissionsArticle...
We report noninvasive monitoring of the transporter−substrate interaction at cell membrane using an oocyte-based field effect transistor (FET), which is based on detection extracellular potential change induced as a result between transporting peptide and substrate membrane. The interface membrane/gate insulator can be monitored during uptake mediated by transporter without any labeling materials fracturing oocyte. Moreover, we discriminate kinetics wild-type mutant-type transporters use...