A5102955391- Hemoglobinopathies and Related Disorders
- Celiac Disease Research and Management
- Erythrocyte Function and Pathophysiology
- Microscopic Colitis
- Eosinophilic Esophagitis
- Iron Metabolism and Disorders
- Blood groups and transfusion
- Hepatitis C virus research
- Galectins and Cancer Biology
- Cancer Immunotherapy and Biomarkers
- Musculoskeletal pain and rehabilitation
- Neonatal Health and Biochemistry
- Fatty Acid Research and Health
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Drug Transport and Resistance Mechanisms
- Genetic factors in colorectal cancer
- Heme Oxygenase-1 and Carbon Monoxide
- Orthopaedic implants and arthroplasty
- Biomedical Ethics and Regulation
- Magnesium in Health and Disease
- Advanced Proteomics Techniques and Applications
- Fibroblast Growth Factor Research
- Organ and Tissue Transplantation Research
- Medical and Biological Ozone Research
- Inflammatory Biomarkers in Disease Prognosis
Azienda Ospedaliera Universitaria Integrata Verona
2017-2024
University of Verona
2010-2024
Istituto Ortopedico Rizzoli
2019-2023
Azienda Ospedaliera di Padova
2017
University of Padua
2017
University of Bologna
1995-2001
Policlinico S.Orsola-Malpighi
1995-2001
Instituto Nazionale Tumori Regina Elena
1997
Tumori Foundation
1996-1997
Medica (Italy)
1995-1996
Many afflictions have been associated with celiac disease, but chance associations may exists. The aim of this study was to establish, by means a multicenter prospective study, the prevalence thyroid impairment among adult patients newly diagnosed disease and evaluate effect 1-yr gluten withdrawal on function.A total 241 consecutive untreated 212 controls were enrolled. In 128 subjects thorough assessment, including intestinal biopsy, repeated within 1 yr dietary treatment. Thyroid function...
The human meniscus plays a crucial role for transmission and distribution of load across the knee, as well shock absorption, joint stability, lubrication, congruity. aim this study was to compare complex geometry, unique ultrastructure tissue composition in healthy (control) pathological conditions provide understanding structural changes that could be helpful future design targetted therapies improvement treatment indications. We analyzed samples collected from 3 multi-organ donors (median...
Isolated familial pseudohyperkalemia is a dominant red cell trait characterized by cold-induced 'passive leak' of potassium ions into plasma. The causative gene this condition ABCB6, which encodes an erythrocyte membrane ABC transporter protein bearing the Langereis blood group antigen system. In study analyzing three new families, we report first functional characterization ABCB6 mutants, including homozygous mutation V454A, heterozygous R276W, and compound mutations R276W R723Q (in trans)....
Background Sickle cell disease, a genetic red disorder inherited in an autosomal recessive manner, occurs throughout the world. Hepatic dysfunction and liver damage may be present sickle but pathogenesis of these conditions is only partially understood.Design Methods Transgenic mice with disease (SAD mice) wild-type were exposed to ischemic/reperfusion stress. The following parameters evaluated: hematologic profile, transaminase bilirubin levels, histopathology, mRNA levels nuclear factor-κB...
Cardiomyopathy deeply affects quality of life and mortality patients with b-thalassemia or transfusion-dependent myelodysplastic syndromes. Recently, a link between Nrf2 activity iron metabolism has been reported in liver ironoverload murine models. Here, we studied C57B6 mice as healthy control nuclear erythroid factor-2 knockout (Nrf2-/-) male aged 4 12 months. Eleven-month-old wild-type Nrf2-/- were fed either standard diet containing 2.5% carbonyl-iron (iron overload [IO]) for weeks. We...
Objective To evaluate the effects of low doses oM-3 polyunsaturated fatty acids on ambulatory blood pressure monitoring parameters in a group mild essential hypertensives. Patients We studied 24 consecutive hypertensive patients from our outpatient clinic with hypertension (diastolic ± 105 mmHg), no previous treatment for 4 weeks at least and other disease. Methods After 3-month run-in period, entered an intervention phase were given 3g (85% eicosapentaenoic docosahexaenoic acid concentrate)...
Over the last decade, evidence has mounted for a prominent etiologic role of femoroacetabular impingement (FAI) in development early hip osteoarthritis (OA). The aim this study was to compare ultrastructure and tissue composition labrum healthy pathological conditions, as FAI OA, provide understanding structural changes which might be helpful future design targeted therapies improve treatment indications. We analyzed labral samples from five multi-organ donors (MCDs) (median age, 38 years),...
Abstract A method was developed in order to analyse high molecular mass proteins by two‐dimensional (2‐D) electrophoresis using a copolymer of acrylamide and allyl agarose instead Bis cross‐linked polyacrylamide (PA) gels sodium dodecyl sulphate‐electrophoresis. In this work, the matrix composition optimised improve resolution larger than 200 kDa. The new gel type does not entrap large protein complexes at application site. Mechanical properties were investigated through rheological...
Background: Chronic pain is a key symptom in fibromyalgia (FM), and its management still challenging for rheumatologists daily practice. FM patients show psychological psychiatric manifestations, going from mood emotional disorders to depression alexithymia that negatively impact their quality of life, limiting activities. Since pharmacological strategies have limited efficacy pain, alternative or complementary non-pharmacological approaches been introduced the clinical FM. Patients methods:...
PURPOSE: The evaluation of lymphocyte subsets by using monoclonal antibodies in neoplastic patients has provided different results, partly relation to the stage disease. Therefore, as a preliminary study cancer treated with immunomodulating drugs, an analysis was performed colorectal carcinoma patients. METHODS: In this study, flow cytometric 33 affected carcinoma, or without metastases. RESULTS: A significant reduction hemoglobin concentrations and hematocrit observed all these subjects,...
Sera from 800 patients referred to our laboratory for celiac sprue screening were tested IgA antiendomysial antibodies on human umbilical cord (HUC-EmA) and IgG antigliadin (AGA) rodent tissue by indirect immunofluorescence. Thirty-three (4.1%) positive at least one of the two antibodies; HUC-EmA found in 25 patients, whereas AGA detected 19 24 subjects, respectively. Twenty-seven (82%) 33 with immunological markers showed subtotal or severe partial villous atrophy consistent sprue,...