A5079451321- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Metal complexes synthesis and properties
- Protein Interaction Studies and Fluorescence Analysis
- DNA and Nucleic Acid Chemistry
- Metal-Organic Frameworks: Synthesis and Applications
- Nanoparticles: synthesis and applications
- Magnetism in coordination complexes
- RNA and protein synthesis mechanisms
- Gold and Silver Nanoparticles Synthesis and Applications
- Surfactants and Colloidal Systems
- Berberine and alkaloids research
- Computational Drug Discovery Methods
- Drug Transport and Resistance Mechanisms
- Magnetic confinement fusion research
- Synthesis and Characterization of Heterocyclic Compounds
- Botanical Research and Chemistry
- Fusion materials and technologies
- Crystal structures of chemical compounds
- Quantum Dots Synthesis And Properties
- Advanced biosensing and bioanalysis techniques
- Metamaterials and Metasurfaces Applications
- Nanocluster Synthesis and Applications
- Synthesis and Biological Evaluation
- Bioactive Compounds and Antitumor Agents
Aliah University
2016-2025
Dhaka Medical College and Hospital
2023-2025
University of Dhaka
2024
Scripps Research Institute
2022-2024
Rangpur Medical College
2023
Dinajpur Medical College
2023
NIHR Clinical Research Network
2023
City University
2022
Queen Mary University of London
2021
Institute of Post Graduate Medical Education and Research
2021
The interaction of two natural protoberberine plant alkaloids berberine and palmatine a synthetic derivative coralyne to three double stranded ribonucleic acids, poly(A). poly(U), poly(I).poly(C) poly(C).poly(G) was studied using various biophysical techniques. Absorbance fluorescence studies showed that the bound cooperatively these RNAs with binding affinities order 104 M−1. Circular dichroic results suggested conformation poly(U) perturbed by all alkaloids, only none. Fluorescence...
Binding of Nile Blue (NB) with calf thymus DNA has been studied using molecular modeling, spectroscopic, and thermodynamic techniques. Our study revealed that NB binds to the helix by two types modes (groove binding intercalation) simultaneously. The showed overall free energy is a combination several negative positive changes. was favored enthalpy entropy changes (due release water from helix). docking validated all experimental evidence minor groove at low concentrations switches...
Interaction of the protoberberine alkaloid coralyne with t-RNA(phe) was investigated using various biophysical techniques. Results absorption and fluorescence studies revealed that binds to t-RNA exhibiting positive cooperativity. Isothermal titration calorimetry results suggested binding predominantly enthalpy driven a smaller favourable entropy term. A surprisingly large component for non-electrostatic contribution from salt dependence data dissection free energy. The enhanced thermal...
The sialic acid-binding immunoglobulin-type lectins (Siglecs) are expressed predominantly on white blood cells and participate in immune cell recognition of self. Most Siglecs contain cytoplasmic inhibitory immunoreceptor tyrosine-based motifs characteristic checkpoint co-receptors that suppress signaling when they recruited to the immunological synapse an activating receptor. Antibodies activatory receptors typically activate by ligating surface. Here, we report conjugation high affinity...
Two phytochemicals, thymol and thymoquinone obtained from thymes (Thymus vulgaris L., Lamiaceae etc.) Nagila Sativa seed, respectively. Both the phytochemicals show several biochemical activities like anticancer, antimicrobial etc. In this paper, we studied affinities of towards calf thymus DNA (CT-DNA) protein (bovine serum albumin). Spectroscopic molecular modelling studies revealed that both compounds have a high affinity toward receptors; protein. binds to minor grooves suitable pockets...
Kimura disease (KD) is a rare chronic inflammatory disorder, and Castleman lymphoproliferative syndrome. (CD) associated with an increased risk for lymphoma. The patient described here 52-year-old female who came one-year history of fever, generalized lymphadenopathy polyserositis. was initially diagnosed on 2 occasions respectively as Kimura’s then disease. Eventually, she had confirmed diagnosis Angioimmunoblastic T-cell lymphoma, after which received cycles combination chemotherapy her...
Lawsone (2-hydroxy-1,4-naphthoquinone), also known as hennotannic acid, is a red-orange dye present in the leaves of henna plant (Lawsonia inermis) having lots biological activities. In this paper, we have investigated structural basis binding affinities towards two different targets namely, calf thymus DNA (CT-DNA) and protein bovine serum albumin (BSA) using experimental computational approaches. This phytochemical binds to minor groove Sudlow site II, Domain III BSA. The constants...
To understand the structure–activity relationship of isoquinoline alkaloids, absorption, fluorescence, circular dichroism, and thermodynamics were employed to study interaction five C-9-ω-amino alkyl ether analogs from plant alkaloid berberine with double-stranded calf thymus DNA. The C-9 derivatization resulted in dramatic enhancements fluorescence emission these compounds. most remarkable changes spectral binding properties BC4 BC5 derivatives. Interactions analogs, which have an...
In this paper, the interaction of rhodamine123 (R123) with calf thymus DNA has been studied using molecular modeling and other biophysical methods like UV–vis spectroscopy, fluoremetry, optical melting, isothermal titration calorimetry, circular dichroic studies. Results showed that binding energy is about −6 to −8 kcal/mol, process favored by both negative enthalpy change positive entropy change. A new method determine different thermodynamic properties calorimetric heat capacity introduced...
Abstract Structural information about drug‐receptor interactions is paramount in drug discovery and subsequent optimization processes. Drugs can bind to multiple potential targets as they contain common chemical entities their structures. Understanding the details of such offer possibilities for repurposing developing potent inhibitors disease pathways. Vinblastine (VLB) a anticancer molecule showing receptor with different affinities degrees structural perturbations. We have investigated...
Elucidation of the molecular aspects small molecule-RNA complexation is prime importance for rational RNA targeted drug design strategies. Towards this, interaction cytotoxic plant alkaloid sanguinarine to three double stranded ribonucleic acids, poly (A).poly(U), poly(I).poly(C) and poly(C).poly(G) was studied using various biophysical thermodynamic techniques. Absorbance fluorescence studies showed that bound cooperatively these RNAs with binding affinities order 104 M−1. Fluorescence...
Berberine, the plant alkaloid, was recently shown to induce self-structure in poly(A) by a unique dilution technique. The interaction of berberine and five 9-(ω-amino) alkyl ether analogues with polyadenylic acid [poly (A)] has been studied understand role an additional anchoring module formation and/or amplification poly(A). binding characterized absorption fluorescence titration, Job's plot isothermal titration calorimetry. All molecules bound cooperatively Self-structure confirmed...
The optical band gap energies in several 2-pyridone derivatives have been measured using solid state UV to explore their semiconductor behavior. electric current measurements for the four compounds exhibit enhanced photoconduction properties under irradiation of light.