A5056457407- Neuroscience and Neural Engineering
- Vagus Nerve Stimulation Research
- EEG and Brain-Computer Interfaces
- Stroke Rehabilitation and Recovery
- Transcranial Magnetic Stimulation Studies
- Advanced Memory and Neural Computing
- Nicotinic Acetylcholine Receptors Study
- Neural dynamics and brain function
- Muscle activation and electromyography studies
- Heart Rate Variability and Autonomic Control
- Memory and Neural Mechanisms
- Analog and Mixed-Signal Circuit Design
- Botulinum Toxin and Related Neurological Disorders
- Spinal Cord Injury Research
- Wireless Body Area Networks
- Neuroscience and Neuropharmacology Research
- Neuroscience and Music Perception
- Olfactory and Sensory Function Studies
- Hearing, Cochlea, Tinnitus, Genetics
- Conducting polymers and applications
- Nerve Injury and Rehabilitation
- Nerve injury and regeneration
- Advanced Sensor and Energy Harvesting Materials
- Glaucoma and retinal disorders
- Neurobiology and Insect Physiology Research
The University of Texas at Dallas
2016-2025
Texas Biomedical Research Institute
2016-2025
University of North Texas at Dallas
2017
Vulintus (United States)
2016
MicroTransponder (United States)
2015
Newcastle upon Tyne Hospitals NHS Foundation Trust
2015
Western Infirmary
2015
Royal Victoria Infirmary
2015
University of California, Irvine
2015
University of Minnesota
2015
Recent animal studies demonstrate that vagus nerve stimulation (VNS) paired with movement induces movement-specific plasticity in motor cortex and improves forelimb function after stroke. We conducted a randomized controlled clinical pilot study of VNS rehabilitation on upper-limb ischemic stroke.Twenty-one participants stroke >6 months before moderate to severe impairment were plus or alone. Rehabilitation consisted three 2-hour sessions per week for 6 weeks, each involving >400 trials. In...
Background and Purpose— Chronic impairment of the arm hand is a common consequence stroke. Animal human studies indicate that brief bursts vagus nerve stimulation (VNS) in conjunction with rehabilitative training improve recovery motor function after In this study, we tested whether VNS could promote generalization, long-lasting recovery, structural plasticity networks. Methods— Rats were trained on fully automated, quantitative task measures forelimb supination. On proficiency, unilateral...
Despite a remarkably precise spatial representation of odorant stimuli in the early stages olfactory processing, projections to (piriform) cortex are more diffuse and show characteristics combinatorial array, with extensive overlap afferent inputs widespread intracortical association connections. Furthermore, although there is increasing evidence for importance temporal structure bulb odorant-evoked output, little known about how this patterning translated within cortical neural ensembles....
Although sensory and motor systems support different functions, both exhibit experience-dependent cortical plasticity under similar conditions. If mechanisms regulating are common to cortices, then methods generating in cortex should be effective cortex. Repeatedly pairing a tone with brief period of vagus nerve stimulation (VNS) increases the proportion primary auditory responding paired (Engineer ND, Riley JR, Seale JD, Vrana WA, Shetake J, Sudanagunta SP, Borland MS, Kilgard MP. 2011....
Abstract The aim of the pilot study was to evaluate effect Vagus Nerve Stimulation (VNS) paired with sounds in chronic tinnitus patients. All participants were implanted and randomized a VNS (n = 16) or control 14) group. After 6 weeks home therapy, all received VNS. device used on 96% days good compliance. weeks, group improved Tinnitus Handicap Inventory (THI) (p 0.0012) compared controls 0.1561). between-group difference 10.3% 0.3393). Fifty percent showed clinically meaningful...
Abstract A novel processing method is described using photolithography to pattern thin‐film flexible electronics on shape memory polymer substrates with mechanical properties tailored improve biocompatability and enhance adhesion between the substrate metal layers. Standard semiconductor wafer techniques are adapted enable robust device design onto a variety of softening tunable moduli. The resulting devices stiff enough (shear modulus ≈700 MPa) assist implantation then soften in vivo (≈300...
Vagus nerve stimulation (VNS) delivered during rehabilitative training enhances neuroplasticity and improves recovery in models of cortical ischemic stroke. However, VNS therapy has not been applied a model subcortical intracerebral hemorrhage (ICH). We hypothesized that paired with after ICH would enhance forelimb motor function beyond alone.Rats were trained to perform an automated, quantitative measure function. Once proficient, rats received intrastriatal injection bacterial collagenase...
Traumatic Brain Injury (TBI) is one of the largest health problems in United States, and affects nearly 2 million people every year. The effects TBI, including weakness loss coordination, can be debilitating last years after initial injury. Recovery motor function often incomplete. We have developed a method using electrical stimulation vagus nerve paired with forelimb use by which we demonstrated enhanced recovery from ischemic hemorrhagic stroke. Here tested hypothesis that (VNS) physical...
Abstract Planar electronics processing methods have enabled neural interfaces to become more precise and deliver information. However, this paradigm is inherently 2D rigid. The resulting mechanical geometrical mismatch at the biotic–abiotic interface can elicit an immune response that prevents effective stimulation. In work, a thiol–ene/acrylate shape memory polymer utilized create 3D softening substrates for stimulation electrodes. This substrate system shown soften in vivo from than 600 6...
Neural plasticity is widely believed to support functional recovery following brain damage. Vagus nerve stimulation paired with different forelimb movements causes long-lasting map in rat primary motor cortex that specific the movement. We tested hypothesis repeatedly pairing vagus upper would improve of function a model stroke. Rats were separated into 3 groups: during rehabilitation (rehab), after rehab, and rehab alone. Animals underwent 4 training stages: shaping (motor skill learning),...
Abstract Neural interfaces have traditionally been fabricated on rigid and planar substrates, including silicon engineering thermoplastics. However, the neural tissue with which these devices interact is both 3D highly compliant. The mechanical mismatch at biotic–abiotic interface expected to contribute response that limits chronic signal recording stimulation. In this work, novel ternary thiol‐ene/acrylate polymer networks are used create softening substrates for electrodes....
Recovery from serious neurological injury requires substantial rewiring of neural circuits. Precisely-timed electrical stimulation could be used to restore corrective feedback mechanisms and promote adaptive plasticity after insult, such as spinal cord (SCI) or stroke. This study provides the first evidence that closed-loop vagus nerve (CLV) based on synaptic eligibility trace leads dramatic recovery most common forms SCI. The addition CLV rehabilitation promoted substantially more forelimb...
Background and objective. Stroke is a leading cause of long-term disability. Currently, there are no consistently effective rehabilitative treatments for chronic stroke patients. Our recent studies demonstrate that vagus nerve stimulation (VNS) paired with training improves recovery function in multiple models stroke. Here, we evaluated the ability VNS to improve forelimb strength when initiated many weeks after cortical subcortical ischemic lesion subjects stable, motor deficits. Methods....
Abstract Exposure-based therapies help patients with post-traumatic stress disorder (PTSD) to extinguish conditioned fear of trauma reminders. However, controlled laboratory studies indicate that PTSD do not as well healthy controls, and exposure therapy has high failure dropout rates. The present study examined whether vagus nerve stimulation (VNS) augments extinction attenuates PTSD-like symptoms in an animal model PTSD. To PTSD, rats were subjected a single prolonged (SPS) protocol, which...
One in 15 school age children have dyslexia, which is characterized by phoneme-processing problems and difficulty learning to read. Dyslexia associated with mutations the gene KIAA0319. It not known whether reduced expression of KIAA0319 can degrade brain's ability process phonemes. In current study, we used RNA interference (RNAi) reduce Kiaa0319 (the rat homolog human KIAA0319) evaluate effect a model phoneme discrimination. Speech discrimination thresholds normal rats are nearly identical...
Loss of upper arm strength after stroke is a leading cause disability. Strategies that can enhance the benefits rehabilitative training could improve motor function stroke. Recent studies in rat model ischemic have demonstrated vagus nerve stimulation (VNS) paired with substantially improves recovery forelimb compared extensive without VNS. Here we report timing and amount affect degree recovery. Similar amounts Delayed VNS delivered 2 h daily sessions resulted significantly less improvement...
Nerve damage can cause chronic, debilitating problems including loss of motor control and paresthesia, generates maladaptive neuroplasticity as central networks attempt to compensate for the peripheral connectivity. However, it remains unclear if this is a critical feature responsible expression symptoms. Here, we use brief bursts closed-loop vagus nerve stimulation (CL-VNS) delivered during rehabilitation reverse aberrant plasticity resulting from forelimb transection. CL-VNS therapy drives...
Brain/machine interfaces could potentially be used in the treatment of a host neurological disorders ranging from paralysis to sensory deficits. Insertion chronic micro-electrode arrays into neural tissue initiates immunological responses, which typically leads formation cellular sheath around implant, resulting loss useful signals. Minocycline has been shown have neuroprotective and neurorestorative effects certain injury neurodegenerative disease models. This study examined minocycline...