A5081429894- Dementia and Cognitive Impairment Research
- Global Cancer Incidence and Screening
- Traumatic Brain Injury Research
- BRCA gene mutations in cancer
- Media Influence and Health
- Lung Cancer Diagnosis and Treatment
- Misinformation and Its Impacts
- Behavioral Health and Interventions
- Cancer Genomics and Diagnostics
- Family Support in Illness
- Public Relations and Crisis Communication
- Optimism, Hope, and Well-being
- Alzheimer's disease research and treatments
- Machine Learning in Healthcare
- Nutrition, Health and Food Behavior
- Health Literacy and Information Accessibility
- Economic and Financial Impacts of Cancer
- Bipolar Disorder and Treatment
- Health, Environment, Cognitive Aging
- Social Media in Health Education
- Colorectal Cancer Screening and Detection
- Genetic factors in colorectal cancer
- Genetics, Bioinformatics, and Biomedical Research
- Genomics and Rare Diseases
- Medication Adherence and Compliance
MaineHealth
2022-2023
Maine Medical Center
2017-2021
Maine Medical Center Research Institute
2017-2021
Maine Medical Center
2020
Harvard University
2013-2014
Brigham and Women's Hospital
2013-2014
Harvard University Press
2013
Fordham University
2006
Mount Sinai Hospital
2006
Icahn School of Medicine at Mount Sinai
2006
Background Communicating scientific uncertainty about public health threats such as COVID-19 is an ethically desirable task endorsed by expert guidelines on crisis communication. However, the communication of challenging because its potential to promote ambiguity aversion—a well-described syndrome negative psychological responses consisting heightened risk perceptions, emotional distress, and decision avoidance. Communication strategies that can inform while mitigating aversion are a...
We sought to describe lung cancer prevalence and mortality in relation socioeconomic deprivation rurality.We conducted a population-based cross-sectional analysis of prevalent cancers from statewide all-payer claims dataset 2012 2016, deaths Maine the state death registry rurality, area index (ADI), geographic area-based measure deprivation. Analyses examined rate ratios for according rurality (small isolated rural, large or urban) ADI (quintiles, with highest reflecting most deprivation)...
<b><i>Background:</i></b> We sought to identify optimal approaches by calibrating longitudinal cognitive performance across studies with different neuropsychological batteries. <b><i>Methods:</i></b> examined four calibrate in nine of Alzheimer's disease (AD) (n = 10,875): (1) common test, (2) standardize and average available tests, (3) confirmatory factor analysis (CFA) continuous indicators, (4) CFA categorical indicators. To compare...
Abstract Introduction Conventional multisession genetic counseling is currently recommended when disclosing apolipoprotein E ( APOE ) genotype for the risk of Alzheimer's disease (AD) in cognitively normal individuals. The objective this study was to evaluate safety brief disclosure protocols AD. Methods A randomized, multicenter noninferiority trial conducted at four sites. Participants were asymptomatic adults having a first‐degree relative with standard protocol by counselors (SP‐GC)...
Abstract Introduction The safety of predicting conversion from mild cognitive impairment (MCI) to Alzheimer's disease (AD) dementia using apolipoprotein E ( APOE ) genotyping is unknown. Methods We randomized 114 individuals with MCI receive estimates 3‐year risk AD informed by (disclosure arm) or not (non‐disclosure in a non‐inferiority clinical trial. Primary outcomes were anxiety and depression scores. Secondary included other psychological measures. Results Upper confidence limits for...
Abstract Background Lung cancer is the leading cause of cancer‐related mortality in United States, and rural states bear a greater burden disease. Methods We analyzed tumor registry data to examine relationships between rurality lung stage at diagnosis treatment. Cases were from Maine Cancer Registry 2012 2015, was defined using rural‐urban commuting areas. Multivariable models used treatment, adjusting for age, sex, poverty, education, insurance status, stage. Results identified 5,338...
This paper presents the first formal evaluation of social media (SM) use in National Children's Study (NCS). The NCS is a prospective, longitudinal study effects environment and genetics on children's health, growth development. employed multifaceted community outreach campaign combination with SM to educate participants their communities about Study. essentially erases geographic differences between people due its omnipresence, which was an important consideration this multi-site national...
Introduction: Rural residents are at elevated risk for lung cancer and related mortality, yet limited research has explored their perspectives on or prevention options, including tobacco treatment screening with low-dose computed tomography (LDCT). This qualitative study examined attitudes beliefs among rural adults who reported either current former use, as well disengagement from the health care system. Methods: We conducted 6 focus groups Maine based age smoking history (n = 50)....
Given advances in AD treatment, APOE genotyping may aid clinical practice by identifying patients at different levels of risk for conversion. Prior work showed that genetic information did not pose psychological risks to volunteer populations who are many years away from disease onset, but little is known about its impact on MCI substantially increased conversion the near future or their care partners. Amnestic were randomized receive 3-year estimates (range: 8–57%) based age and diagnosis...
To identify the optimal approach for calibrating longitudinal cognitive performance across studies with different neuropsychological batteries to use as a common phenotype in genetic research on Alzheimer's disease (AD). We examined four approaches calibrate eight large of AD (N=10,997): (1) selecting test datasets, (2) standardizing and averaging together all tests, (3) confirmatory factor analysis (CFA) continuous indicators, (4) CFA categorical indicators. Datasets included Disease...
APOE genotyping, a well-documented determinant of genetic risk for AD, is available direct-to-consumer and via research, but little known about the impact on highest group, e4 homozygotes. We compared persons who learned that they were e4(-), heterozygotes (e4-HT), homozygotes (e4-HM) to explore effects disclosure mood, perceived AD reducing behaviors. Data combined across three randomized trials testing cognitively normal older adults. Participants their genotype estimate (range: 6–77%)...
<sec> <title>BACKGROUND</title> Communicating scientific uncertainty about public health threats such as COVID-19 is an ethically desirable task endorsed by expert guidelines on crisis communication. However, the communication of challenging because its potential to promote <i>ambiguity aversion</i>—a well-described syndrome negative psychological responses consisting heightened risk perceptions, emotional distress, and decision avoidance. Communication strategies that can inform...
Project Description: Research has shown that disclosing genetic risk information about Alzheimer's disease (AD) to volunteer populations does not create distress in the year following disclosure, and can motivate changes advance planning health behaviors. However, little is known long-term impact of disclosure. The potential exists for increase over time motivation behavior change decrease. REVEAL Study a series multisite randomized controlled trials examining psychological behavioral using...
Literature suggests 10–15% of people early in the course late-onset Alzheimer's disease (LOAD) present with a prominent executive functioning deficit. Imaging and neuropathological studies have found differences between these individuals those more typical memory-prominent LOAD. We sought to use genome-wide single nucleotide polymorphism (SNP) data estimate heritability memory among stage Participants were from Disease Neuroimaging Initiative (ADNI) Uniform Data Set (UDS) subset genotyped...
There is tremendous variability in the rate of cognitive decline over course Alzheimer's disease (AD) that cannot be explained by demographic, health, or clinical features, and thus likely genetic origin. Determining underpinnings AD might help reveal previously unidentified biological pathways responsible for progression. Unfortunately, identification factors hampered absence a cohort longitudinally followed persons with sufficient size from any single study. Thus, our objective was to...
The COVID-19 pandemic has engendered widespread fear and skepticism about recommended risk-reducing behaviors including vaccination. Health agencies are faced with the need to communicate public in ways that both provide reassurance promote behaviors. Communication strategies prosocial (PS) values hope being widely used; however, existing research on persuasiveness of these offered mixed evidence. There is also very little examining comparative effectiveness PS hope-promoting (HP) strategies.
Objective: To examine the cholinergic system in vivo using pharmacologic arterial spin-labeling (ASL) perfusion MRI. Background In imaging of function has potential advancing our understanding important role it plays cognition. Pharmacologic MRI, by examining changes cerebral blood flow (CBF) following drug administration, can elucidate physiological effects with high anatomic resolution and thereby link cognitive modulation to specific anatomical structures. Design/Methods: Healthy young...
You have accessJournal of UrologyGeneral & Epidemiological Trends Socioeconomics: Practice Patterns, Quality Life and Shared Decision Making I1 Apr 2017PD06-04 FEASIBILITY AND INITIAL REPORT OF INCORPORATING A SHARED DECISION MAKING METRIC AT POINT SERVICE IN MEN WITH LOCALIZED PROSTATE CANCER Patrick Murray, Paul Han, Gregory Mills, Stephen Prato, Caitlin Gutheil, Leo Waterston, Jesse Sammon, Moritz Hansen MurrayPatrick Murray More articles by this author , HanPaul Han MillsGregory Mills...