A5076656809- Osteoarthritis Treatment and Mechanisms
- Knee injuries and reconstruction techniques
- Spine and Intervertebral Disc Pathology
- Lower Extremity Biomechanics and Pathologies
- Orthopaedic implants and arthroplasty
- Shoulder Injury and Treatment
- Medical Imaging and Analysis
- Total Knee Arthroplasty Outcomes
- Musculoskeletal pain and rehabilitation
- Shoulder and Clavicle Injuries
- Tendon Structure and Treatment
- Bone fractures and treatments
- Bone and Joint Diseases
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Sports injuries and prevention
- Musicians’ Health and Performance
- Hip and Femur Fractures
- Bone Tissue Engineering Materials
- Bone health and osteoporosis research
- Veterinary Orthopedics and Neurology
- Mesenchymal stem cell research
- Cancer, Stress, Anesthesia, and Immune Response
- Plant Toxicity and Pharmacological Properties
- Veterinary Equine Medical Research
Beaumont Hospital, Royal Oak
2016-2025
University of Michigan
2019-2025
Wayne State University
2025
Beaumont Health
2014-2024
Michigan United
2024
Orthopaedic Research Laboratories
2015-2020
Although numerous spinal biologics are commercially available, a cost-effective and safe bone graft substitute material for spine fusion has yet to be proven. In this study, "3D-Paints" containing varying volumetric ratios of hydroxyapatite (HA) human demineralized matrix (DBM) in poly(lactide-co-glycolide) elastomer were three-dimensional (3D) printed into scaffolds promote osteointegration rats, with an end goal without the need recombinant growth factor. Spine was evaluated by manual...
Preclinical models of osteoarthritis (OA) are crucial for the study disease mechanisms and development critically-needed disease-modifying therapeutics. While surgical OA models, such as destabilization medial meniscus (DMM), have been gold standard in field decades, noninvasive joint loading-based increased popularity utility. To facilitate standardization anterior cruciate ligament rupture (ACLR) model mice, we present Mo bile J oint-Injury O perator (MoJO) - an open-source protocol with...
Abstract This study investigates the role of chemokine CXCL16 and its receptor, CXCR6, in post-traumatic osteoarthritis (PTOA) joint nociception, highlighting potential targeting CXCL16-CXCR6 axis for therapeutically managing inflammation pain. Following injury mice, signaling is activated synovium, driven by synovial fibroblasts macrophages. Human OA synovium also exhibited increased CXCR6 gene expression. stimulated a pro-inflammatory response macrophages, contrasting with an...
Purpose Degradation of articular cartilage (AC) due to injury the knee joint may initiate post-traumatic osteoarthritis (PTOA). Failure diagnose onset disease at an early stage makes cure ineffective for PTOA. This study investigated consequences a mechanical in rabbit model using microscopic magnetic resonance imaging (µMRI) high resolution.
ABSTRACT ACL rupture is a major risk factor for post‐traumatic osteoarthritis (PTOA) development. Little information exists on acute systemic metabolic indicators of disease Thirty‐six female Lewis rats were randomized to Control or noninvasive anterior cruciate ligament (ACLR) and three post‐injury time points: 72 h, 4 weeks, 10 weeks ( n = 6). Serum was collected analyzed by 1 H nuclear magnetic resonance (NMR) spectroscopy combined direct injection liquid chromatography (LC)‐mass...
The objective of this study was to quantify and compare the contrast-enhancing properties anionic contrast agent ioxaglate/Hexabrix, cationic CA4+ for biochemical morphological characterization intervertebral disc (IVD) via μCT. Optimal concentrations were determined by incubating rat lumbar IVDs in dilutions Hexabrix-320 (20%, 30%, 40%, 50%) (10, 20, 30, 40 mg I/ml). μCT imaging performed at 70 kVp, 114 μA, 250 ms integration time, 12 μm voxel size. kinetics enhancement quantified with...
Abstract Assess acute alterations in bone turnover, microstructure, and histomorphometry following noninvasive anterior cruciate ligament rupture (ACLR). Twelve female Lewis rats were randomized to receive ACLR or Sham loading ( n = 6/group). In vivo μCT was performed at 3, 7, 10, 14 days postinjury quantify compartment‐dependent subchondral (SCB) epiphyseal trabecular remodeling. Near‐infrared (NIR) molecular imaging used measure anabolism (800 CW BoneTag) catabolism (Cat K 680 FAST)....
ABSTRACT Polyethylene wear is a known complication in total joint arthroplasty, however, vivo rates reverse shoulder arthroplasty (RTSA) remain largely unknown. This study aimed to quantify volumetric and surface deviation changes retrieved RTSA humeral liners using novel micro‐computed tomography (μCT)‐based technique. After IRB‐approval, 32 (single manufacturer model) with term‐of‐service greater than 90 days were analyzed. Clinical demographics surgical data collected via chart review....