A5046892695- Osteoarthritis Treatment and Mechanisms
- Knee injuries and reconstruction techniques
- Pain Mechanisms and Treatments
- Total Knee Arthroplasty Outcomes
- Cell Adhesion Molecules Research
- Drug-Induced Hepatotoxicity and Protection
- Inflammatory mediators and NSAID effects
- Pharmacological Effects and Assays
- Cytokine Signaling Pathways and Interactions
- Pharmacological Receptor Mechanisms and Effects
- Bone health and treatments
- Bone and Joint Diseases
- Muscle activation and electromyography studies
- Toxoplasma gondii Research Studies
- Cannabis and Cannabinoid Research
University of Michigan
2020-2025
Orthopaedic Research Laboratories
2021-2023
Synovium is acutely affected following joint trauma and contributes to post-traumatic osteoarthritis (PTOA) progression. Little known about discrete cell types molecular mechanisms in PTOA synovium. We aimed describe synovial populations their dynamics PTOA, with a focus on fibroblasts. also sought define of Wnt/β-catenin signalling, given its emerging importance arthritis.We subjected mice non-invasive anterior cruciate ligament rupture as model human injury. performed single-cell...
Knee joints are densely innervated by nociceptors. In human knees and rodent models, sprouting of nociceptors has been reported in late-stage osteoarthritis (OA). Here, we sought to describe progressive nociceptor remodeling early OA, using four distinct experimental mouse models.
Preclinical models of osteoarthritis (OA) are crucial for the study disease mechanisms and development critically-needed disease-modifying therapeutics. While surgical OA models, such as destabilization medial meniscus (DMM), have been gold standard in field decades, noninvasive joint loading-based increased popularity utility. To facilitate standardization anterior cruciate ligament rupture (ACLR) model mice, we present Mo bile J oint-Injury O perator (MoJO) - an open-source protocol with...
ABSTRACT Objective Knee joints are densely innervated by nociceptors. Sprouting of nociceptors has been reported in late-stage osteoarthritis (OA), both human knees and rodent models. Here, we sought to describe progressive nociceptor remodeling four mouse models knee OA, capturing early disease. Methods Sham surgery, destabilization the medial meniscus (DMM), partial meniscectomy (PMX), or non-invasive anterior cruciate ligament rupture (ACLR) was performed right 10-12-week old male C57BL/6...
ABSTRACT Objectives Synovium is acutely affected following joint trauma and contributes to post-traumatic osteoarthritis (PTOA) progression. Little known about discrete cell types molecular mechanisms in PTOA synovium. We aimed describe synovial populations their dynamics PTOA, with a focus on fibroblasts. also sought define of Wnt/β-catenin signaling, given its emerging importance arthritis. Methods subjected mice non-invasive anterior cruciate ligament rupture as model human injury....
ABSTRACT Objective To elucidate sex differences in synovitis, mechanical sensitization, structural damage, bone remodeling, and the synovial transcriptome anterior cruciate ligament rupture (ACLR) mouse model of post-traumatic osteoarthritis (PTOA). Methods Male female 12-week-old C57Bl/6 mice were randomized to noninvasive ACLR or sham (n=9/sex/group/timepoint). Knee hyperalgesia, allodynia, intra-articular MMP activity (via intravital imaging) measured longitudinally. Trabecular...