A5060902883- Cutaneous lymphoproliferative disorders research
- Fungal Infections and Studies
- Metal-Catalyzed Oxygenation Mechanisms
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Histone Deacetylase Inhibitors Research
- Microbial Natural Products and Biosynthesis
- Glycosylation and Glycoproteins Research
- Phytochemical compounds biological activities
- Metal complexes synthesis and properties
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- T-cell and Retrovirus Studies
- Extracellular vesicles in disease
- Fungal Biology and Applications
- Nail Diseases and Treatments
Tel Aviv University
2004-2021
Rabin Medical Center
2013-2021
University of British Columbia
2003
Mycothiol is the major thiol present in most actinomycetes and produced from pseudodisaccharide 1D-myo-inosityl 2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins). A transposon mutant of Mycobacterium smegmatis shown to be GlcNAc-Ins mycothiol deficient was sequenced identify a putative glycosyltransferase gene designated mshA. The ortholog tuberculosis, Rv0486, used complement phenotype.
Ribonucleotide reductases (RNRs) catalyze the conversion of ribonucleotides to deoxyribonucleotides and are essential for de novo DNA synthesis repair. Streptomyces spp. contain genes coding two RNRs, either which is sufficient vegetative growth. The class Ia RNR encoded by nrdAB genes, II nrdJ, coexpressed with nrdR. We previously showed that coelicolor nrdR gene encodes a protein, NrdR, represses transcription both sets genes. NrdR member highly conserved family proteins confined...
Ribonucleotide reductases (RNRs) catalyze the conversion of ribonucleotides to deoxyribonucleotides and are essential for de novo DNA synthesis repair. Streptomycetes contain genes coding two RNRs. The class Ia RNR is oxygen dependent, II independent requires coenzyme B12. Either sufficient vegetative growth. We show here that Streptomyces coelicolor M145 nrdABS encoding regulated by 5'-untranslated region contains a 123-nucleotide B12 riboswitch. Similar riboswitches present in...
Summary Ribonucleotide reductases (RNRs) catalyse the conversion of ribonucleotides to deoxyribonucleotides and are essential for de novo DNA synthesis repair. Streptomyces spp. contain genes coding two RNRs. We show here that coelicolor M145 nrdAB encoding an oxygen‐dependent class I RNR co‐transcribed with nrdS , which encodes AraC‐like regulatory protein. Likewise, II oxygen‐independent nrdJ gene forms operon a likely gene, nrdR protein possessing ATP‐cone domain like those present in...
The 2 histone deacetylase inhibitors (HDACIs) approved for the treatment of cutaneous T-cell lymphoma (CTCL) including mycosis fungoides/sezary syndrome (MF/SS), suberoylanilide hydroxamic acid (SAHA) and romidepsin, are associated with low rates overall response high adverse effects. Data regarding combination treatments HDACIs is sparse. Butyroyloxymethyl diethylphosphate (AN-7) a novel HDACI, which was found to have selective anticancer activity in several cell lines animal models. aim...
Recent studies suggest that folliculotropic mycosis fungoides (FMF), the most common variant of (MF), presents with 2 distinct clinicopathological stages: early indolent stage and more aggressive advanced/tumour stage. To further characterize these stages, miR-155 expression was studied qRT-PCR found to be significantly higher in biopsies tumour-stage FMF compared early-stage inflammatory dermatoses. There no statistically significant difference between MF, nor MF. Immunohistochemical...