A5051765836- Heavy Metal Exposure and Toxicity
- Botulinum Toxin and Related Neurological Disorders
- Aluminum toxicity and tolerance in plants and animals
- Intramuscular injections and effects
- Neonatal Respiratory Health Research
- Vaccine Coverage and Hesitancy
- SARS-CoV-2 and COVID-19 Research
- Diphtheria, Corynebacterium, and Tetanus
- Biochemical and Structural Characterization
- Congenital Diaphragmatic Hernia Studies
- Heparin-Induced Thrombocytopenia and Thrombosis
- Trace Elements in Health
- Platelet Disorders and Treatments
- Respiratory Support and Mechanisms
- Analytical Methods in Pharmaceuticals
- Drug-Induced Adverse Reactions
- Pharmaceutical studies and practices
- Metabolism and Genetic Disorders
- Neonatal Health and Biochemistry
- Protein Hydrolysis and Bioactive Peptides
- Vitamin K Research Studies
- Pharmacological Effects and Assays
- Streptococcal Infections and Treatments
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Biosimilars and Bioanalytical Methods
Paul Ehrlich Institut
2010-2025
Medical University of Vienna
2021
Asklepios Klinik Langen
2021
Goethe University Frankfurt
1991-1993
Merck & Co., Inc., Rahway, NJ, USA (United States)
1993
University Children’s Hospital Basel
1970
Several cases of unusual thrombotic events and thrombocytopenia have developed after vaccination with the recombinant adenoviral vector encoding spike protein antigen severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (ChAdOx1 nCov-19, AstraZeneca). More data were needed on pathogenesis this clotting disorder.We assessed clinical laboratory features 11 patients in Germany Austria whom thrombosis or had ChAdOx1 nCov-19. We used a standard enzyme-linked immunosorbent assay to detect...
<title>Abstract</title> <bold>Background</bold>. Vaccines are important for managing the COVID-19 pandemic caused by SARS-CoV-2. However, following widespread vaccination using a recombinant adenoviral vector encoding spike protein antigen of SARS-CoV-2 (AZD1222, AstraZeneca), reports have emerged some vaccine recipients developing unusual thrombotic events and thrombocytopenia. We investigated whether such patients could prothrombotic disorder platelet-activating antibodies directed against...
Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a severe adverse event of SARS-CoV-2 vaccination. We describe the characteristics patients reported in Germany based on Brighton Collaboration (BC) case definition criteria for Thrombosis and Thrombocytopenia Syndrome (TTS) focus with complete anti-platelet factor 4 (PF4)-antibody laboratory work up.The drug reaction database Paul-Ehrlich Institute was queried TTS cases following ChAdOx1 nCoV-19 vaccination from February 1, until...
The cardiovascular effects and pharmacokinetics of once-daily enalapril were studied after single-dose subchronic treatment in eight patients with hypertension by use ambulatory blood pressure monitoring. Enalapril, 10 mg, was given at either 7 AM or PM a randomized crossover design. In addition, inhibition serum converting enzyme studied. Subchronic am significantly reduced during the day but less effective night. dosing pm further decreased nighttime followed slow increase day, no effect...
Abstract Purpose In 2015, an interdisciplinary project was started to fill the gap of knowledge on toxicokinetics aluminium (Al) after exposure from adjuvanted products for subcutaneous immunotherapy (SCIT). Methods Two complementary initiatives are explained. The results two studies reviewed and put in connection with overarching goal. An estimate is given which steps have been reached still needed. Results Recent vivo data provided evidence systemically available Al SCIT rats (Weisser et...
Appropriate nomenclature for all pharmaceutical substances is important clinical development, licensing, prescribing, pharmacovigilance, and identification of counterfeits. Nonproprietary names that are unique globally recognized assigned by the International Names (INN) Programme World Health Organization (WHO). In 1991, INN implemented first scheme monoclonal antibodies. To accompany biotechnological this has evolved over years; however, since was introduced, pharmacological contained an...
Abstract The safety of aluminium (Al) exposure from sources such as food, parenteral nutrition or adjuvanted medicinal products is still a matter uncertainty. Since toxicokinetic studies in humans are lacking, model predictions warranted for risk assessment. Recently, we established physiologically based (PBTK) Al built on comprehensive $$^{26}\textrm{Al}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:mmultiscripts> <mml:mrow/> <mml:mn>26</mml:mn>...
<title>Abstract</title> <bold>Background</bold>. Vaccines are important for managing the COVID-19 pandemic caused by SARS-CoV-2. However, following widespread vaccination using a recombinant adenoviral vector encoding spike protein antigen of SARS-CoV-2 (AZD1222, AstraZeneca), reports have emerged some vaccine recipients developing unusual thrombotic events and thrombocytopenia. We investigated whether such patients could prothrombotic disorder platelet-activating antibodies directed against...
A sufficient quantitative understanding of aluminium (Al) toxicokinetics (TK) in man is still lacking, although highly desirable for risk assessment Al exposure. Baseline exposure and the contamination severely limit feasibility TK studies administering naturally occurring isotope
SUMMARY In a double blind study the effect of phenobarbitone on neonatal hyperbilirubinaemia and frequency exchange transfusion was investigated. Newborn infants admitted were randomly assigned to one two groups. The treated group comprised 56 control 60 infants. Either placebo solution or injected i.m. at 8 hourly intervals for total 10 injections. single dose varied between 1 mg 5 according weight. One had be performed in 11 group. This difference is statistically significant....
. For the COVID-19 vaccines used in Germany, severe allergic (anaphylactic) reactions after vaccination have been reported very rare cases. While Comirnaty and Spikevax are mRNA vaccines, Vaxzevria Jcovden comprise vector Nuvaxovid a recombinant spike protein vaccine. The reporting rate of anaphylaxis was higher females receiving their first dose, with 0.97 1.12 reports per 100,000 vaccinations for Spikevax, respectively, compared vaccinated males subsequent vaccinations....