A5101776328- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Cardiac Ischemia and Reperfusion
- Coronary Interventions and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Autophagy in Disease and Therapy
- Acute Myocardial Infarction Research
- Advanced MRI Techniques and Applications
- Cardiac Arrhythmias and Treatments
- Heart Rate Variability and Autonomic Control
- Adipose Tissue and Metabolism
- S100 Proteins and Annexins
- Cancer-related Molecular Pathways
- Cardiac Arrest and Resuscitation
- Cardiac electrophysiology and arrhythmias
- Receptor Mechanisms and Signaling
- Viral Infections and Immunology Research
- Cardiac pacing and defibrillation studies
- Sirtuins and Resveratrol in Medicine
- Cardiac, Anesthesia and Surgical Outcomes
- Virus-based gene therapy research
- Cancer-related gene regulation
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Disease and Adiposity
- Angiogenesis and VEGF in Cancer
Harbin Medical University
2008-2021
First Affiliated Hospital of Harbin Medical University
2006-2021
Digestive Care (United States)
2009
Education Department of Heilongjiang Province
2009
Yangon University of Economics
2009
CAE (Canada)
2004
Atherosclerosis (AS) is a life-threatening vascular disease. RNA N6-methyladenosine (m6A) modification level dysregulated in multiple pathophysiologic processes including AS. In this text, the roles and molecular mechanisms of m6A writer METTL3 AS progression were explored vitro vivo. present study, cell proliferative, migratory, tube formation capacities assessed through CCK-8, Transwell migration, assays, respectively. was examined commercial kit. protein levels genes measured RT-qPCR...
Renin-angiotensin-aldosterone system has been demonstrated to be associated with both congestive heart failure (CHF) and atrial fibrillation (AF). This study investigated the effects of spironolactone, a kind aldosterone antagonist, on electrical remodeling fibrosis in CHF dogs induced by chronic rapid ventricular pacing.Twenty one were randomly divided into sham-operated group, control spironolactone group. In group paced at 220 beats per minute for 6 weeks. Additionally, 15 mg x kg(-1)...
Atherosclerosis (AS), a chronic inflammatory disease of the arterial wall, remains dominant cause death and disability globally. Quercetin has been evidenced to be effective against AS, but exact mechanisms are still largely unclear. Oxidized low-density lipoprotein (ox-LDL)-induced human aortic endothelial cells (HAECs) mouse RAW264.7 macrophages were established, with quercetin treatment or p16, p21 SERPINE1 siRNA transfection. Cellular senescence was assessed by SA-β-gal staining...
Platelet-neutrophil interaction is well known for its role in inflammatory diseases; however, biological atherosclerosis (AS) progression remains unclear. Human peripheral blood neutrophils were obtained to compare toll-like receptor 4 (TLR4), tumor necrosis factor α (TNF-α), interleukin (IL)-1β and myeloid-related proteins 8/14 (Mrp8/14) levels 22 AS patients with those 18 healthy controls using quantitative real-time polymerase chain reaction (qRT-PCR) enzyme-linked immunosorbent assay...
Matrine, an alkaloid isolated from the traditional Chinese medicine Sophora flavescens AIT has exhibited a number of therapeutic effects on cardiovascular and liver diseases. The purpose present study was to investigate whether matrine protective effect heart failure in rats. Coronary artery ligation used induce (CHF) model Four weeks following procedure, rats were treated with different doses for one month. Histopathological examination demonstrated that treatment alleviated myocardial...
Low shear stress (LSS) is a well‑established risk factor resulting in endothelial apoptosis and atherosclerosis. Autophagy has been reported to be involved the development of However, whether autophagy participates LSS‑induced atherosclerosis remains unclear. The effect its association with apoptosis, atherosclerosis, controversial. Therefore, present study, level role human umbilical vein cells (HUVECs) exposed LSS was examined. results revealed that increased formation autophagosomes MAP1...
Background No-reflow phenomenon during percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI) is a predictive factor of continuous ischemia, ventricular remodeling and cardiac dysfunction, which closely associated with worse prognosis. This study aimed to evaluate intracoronary nitroprusside in the prevention no-reflow AMI. Methods Ninety-two consecutive patients AMI, who underwent primary PCI within 12 hours onset, were randomly assigned 2 groups: administration...
1. In the present study, temporal and concentration-dependent cardioprotective effects of rapamycin against ischaemia-reperfusion (I/R) injury, as well underlying mechanisms, were investigated. 2. Rat Langendorff-perfused isolated hearts exposed to 40 min global ischaemia followed by 120 reperfusion. Hearts perfused with different concentrations before after ischaemia. Myocardial injury was assessed in terms infarct size release lactate dehydrogenase (LDH) creatine kinase (CK). The...
<h3>Objectives</h3> This study aimed to investigate whether the combination of acute or chronic atorvastatin treatment with ischaemic postconditioning (Ipost) exerts differential effects within hearts diabetic and non-diabetic rats. <h3>Methods</h3> Diabetic rats were randomly assigned six groups: (1) nonconditioning; (2) Ipost; (3) statin (50 µmol/l during reperfusion) without (4) (5) (10 mg/kg per day for 2 weeks) (6) Ipost. Hearts from these subjected 30 min global ischaemia, followed by...
<h3>Objective</h3> This study is to investigate if the combination therapy of cilostazol and ischemic postconditioning (Ipost) could protect non-diabetic diabetic rat hearts against reperfusion injury after long-term atorvastatin treatment. <h3>Methods</h3> Non-diabetic rats were randomly assigned six groups: (1) nonconditioning, (2) Ipost, (3) (2 mg/kg/day for two weeks), (4) (5) (20 mg/kg once before reperfusion), (6) atorvastatin, cilostazol, Ipost. Infarct sise, haemodynamics expression...