A5050966421- DNA and Nucleic Acid Chemistry
- Ionosphere and magnetosphere dynamics
- Advanced biosensing and bioanalysis techniques
- Curcumin's Biomedical Applications
- Solar and Space Plasma Dynamics
- Computational Drug Discovery Methods
- RNA Interference and Gene Delivery
- Chemical Synthesis and Analysis
- Earthquake Detection and Analysis
- Chemical Synthesis and Reactions
- Synthesis and biological activity
- Geomagnetism and Paleomagnetism Studies
- Magnetic confinement fusion research
- HIV/AIDS drug development and treatment
- Click Chemistry and Applications
- Synthesis of Organic Compounds
- Plasma Diagnostics and Applications
- Synthesis and Characterization of Heterocyclic Compounds
- RNA and protein synthesis mechanisms
- Natural Antidiabetic Agents Studies
- Synthesis and Biological Evaluation
- Cancer therapeutics and mechanisms
- Photonic Crystals and Applications
- Multicomponent Synthesis of Heterocycles
- Sulfur-Based Synthesis Techniques
Indian Institute of Information Technology Allahabad
2016-2025
Sanjay Gandhi Post Graduate Institute of Medical Sciences
2011-2020
Centre of Biomedical Research
2011-2020
Defence Institute of Physiology and Allied Sciences
2018
Banaras Hindu University
1985-2014
Health Affairs
2014
Chhatrapati Shahu Ji Maharaj University
2013
Institute of Engineering
2013
Sri Venkateswara University
2013
Murata (Japan)
2011
A single novel enzyme, glyoxalase III, which catalyses the conversion of methylglyoxal into D-lactate without involvement GSH, has been detected in and purified from Escherichia coli. Of several carbonyl compounds tested, only alpha-ketoaldehydes phenylglyoxal were found to be substrates for this enzyme. Glyoxalase III is active over a wide range pH with no sharp optimum. In its native form it an M(r) 82000 +/- 2000, composed two subunits equal M(r). Glutathione analogues, are inhibitors I,...
Abstract: This research presents an advanced IoT-enabled fire detection and emergency response system, designed to revolutionize incident management by integrating Wireless Sensor Networks (WSN) Artificial Intelligence (AI). The system employs flame smoke sensors connected Arduino microcontroller continuously monitor fire-prone areas detect potential hazards in real time. Once a is detected, the captures precise GPS coordinates using module, which are then transmitted centralized cloud...
In the present study curcumin bioconjugates, viz. di-O-glycinoylcurcumin (I), di-O-glycinoyl-C(4)-glycylcurcumin (II), 5'-deoxy-5'-curcuminylthymidine (5'-cur-T) (IV), and 2'-deoxy-2'-curcuminyluridine (2'-cur-U) (V) have been synthesized characterized by elemental analysis (1)H NMR. The turmeric peptide (Tp) was isolated from aqueous extract of rhizome. antibacterial activity these four bioconjugates also sodium salt (III) tested particularly for beta-lactamase-producing microorganisms.
Antioxidant and free radical scavenging effect of black tea theaflavins has been shown in many epidemiological studies. In the present work we report protective mechanism on biomarkers oxidative stress, which are elevated during stress conditions. We hereby vitro erythrocyte malondialdehyde (MDA), intracellular reduced glutathione (GSH), plasma membrane redox system (PMRS) rats. The theaflavin PMRS also validated through an silico docking simulation study using Molegro Virtual Docker (MVD)....
Curcumin, an active biphenolic molecule present in turmeric (Curcuma longa), has been reported to elicit plethora of health protective effects. The study was carried out vitro, vivo and silico investigate the modulatory effects curcumin on erythrocyte membrane Na(+)/K(+)-ATPase activity. In vitro (10(-) (5) M 10(-) (8) M) incubated with human erythrocytes membrane. (340 mg/kg b.w. 170 b.w.) supplemented wistar rats for 21 days. silico, catalytic unit α (3b8e.pdb) protein used as a receptor...
Screening of " drug-like" molecule from the molecular database produced through high throughput techniques and their large repositories requires robust classification. In our work, a set heuristically chosen nine descriptors including four Lipinski's rule, were used as classification parameter for screening "drug-like" molecules. The robustness was compared with fundamental Lipinski. Back propagation neural network based classifier applied on 60000 molecules of, "non Classification result...
In order to enhance the bioavailability of curcumin its conjugates with piperic acid and glycine were synthesized by esterifying 4 4' phenolic hydroxyls, sites metabolic conjugation. Antiproliferative apoptotic efficacy was investigated in MCF-7 MDA-MB-231 cell lines. <TEX>$IC_{50}$</TEX> values di-O-glycinoyl (CDG) di-O-piperoyl (CDP) esters found be comparable that curcumin. Both induced chromatin condensation fragmentation body formation. CDP exposure cells apoptosis initiating loss...