A5011962134- Cytokine Signaling Pathways and Interactions
- Bioinformatics and Genomic Networks
- Computational Drug Discovery Methods
- PI3K/AKT/mTOR signaling in cancer
- Rheumatoid Arthritis Research and Therapies
- Monoclonal and Polyclonal Antibodies Research
- Cell Image Analysis Techniques
- ATP Synthase and ATPases Research
- Protein Degradation and Inhibitors
- Cancer, Hypoxia, and Metabolism
- Systemic Lupus Erythematosus Research
- Biochemical and Molecular Research
- Mathematical Biology Tumor Growth
- CAR-T cell therapy research
- 14-3-3 protein interactions
Sanofi (France)
2022-2024
Genopole (France)
2020-2024
Sanofi (Mexico)
2023
Université Paris-Saclay
2020
Macrophages play an essential role in rheumatoid arthritis. Depending on their phenotype (M1 or M2), they can a the initiation resolution of inflammation. The M1/M2 ratio arthritis is higher than healthy controls. Despite this, no treatment targeting specifically macrophages currently used clinics. Thus, devising strategies to selectively deplete proinflammatory and promote anti-inflammatory could be promising therapeutic approach. State-of-the-art molecular interaction maps M1 M2 are...
Abstract Background: Long-term survival in cancers with poor prognosis, such as metastatic pancreatic ductal adenocarcinoma (mPDAC), glioblastoma (GBM-IDHwt), and extensive-stage small cell lung cancer (ES-SCLC), is exceedingly rare. The ROSALIND study designed to explore the biological factors that contribute exceptional these by comparing multi-omic clinical profiles of long-term survivors (outliers) those patients who exhibit standard outcomes. By building a comprehensive molecular...
Rheumatoid Arthritis (RA) is an autoimmune disease of unknown aetiology involving complex interactions between environmental and genetic factors. Its pathogenesis suspected to arise from intricate interplays signalling, gene regulation metabolism, leading synovial inflammation, bone erosion cartilage destruction in the patients’ joints. In addition, resident synoviocytes macrophage fibroblast types can interact with innate adaptive immune cells contribute disease’s debilitating symptoms....
Abstract Rheumatoid arthritis (RA) is a systemic autoimmune disease that affects the synovial joints of body. fibroblast-like synoviocytes (RA FLS) are central players in pathogenesis, as they involved secretion cytokines and proteolytic enzymes, exhibit invasive traits, high rate self-proliferation an apoptosis-resistant phenotype. We aim at characterizing transcription factors (TFs) master regulators RA FLS could potentially explain phenotypic traits. make use differentially expressed...
Fibroblasts, the most abundant cells in connective tissue, are key modulators of extracellular matrix (ECM) composition. These spindle-shaped capable synthesizing various proteins and collagen. They also provide structural framework (stroma) for tissues play a pivotal role wound healing process. While they maintainers ECM turnover regulate several physiological processes, can undergo transformations responding to certain stimuli display aggressive phenotypes that contribute disease...
Abstract Rheumatoid arthritis is a complex disease marked by joint pain, stiffness, swelling, and chronic synovitis, arising from the dysregulated interaction between synoviocytes immune cells. Its unclear etiology makes finding cure challenging. The concept of digital twins, used in engineering, can be applied to healthcare improve diagnosis treatment for diseases like rheumatoid arthritis. In this work, we pave path towards twin arthritic building large, modular biochemical reaction map...
Abstract Macrophages play an essential role in rheumatoid arthritis (RA). Depending on their phenotype (M1 or M2), they can a the initiation resolution of inflammation. The M1/M2 ratio RA is higher than healthy controls. Despite this, no treatment targeting specifically macrophages currently used clinics. Thus, devising strategies to selectively deplete proinflammatory and promote anti-inflammatory could be promising therapeutic approach RA. State-of-the-art molecular interaction maps M1 M2...