Objective To understand the clinical characteristics of COVID-19 patients with clinically diagnosed bacterial co-infection (CDBC), and therefore contributing to their early identification prognosis estimation. Method 905 from 7 different centers were enrolled. The demography data, manifestations, laboratory results, treatments collected accordingly for further analyses. Results Around 9.5% enrolled CDBC. Older or cardiovascular comorbidities have increased CDBC probability. Increased body...

Background: COPD is a multi-pathogenesis disease mainly caused by smoking. A further understanding of the mechanism smoking-related might contribute to preventions and treatments this in early stages. This study was designed identify characteristics M2 macrophages for better about their potential role. Materials methods: models were built C57BL/6 mouse cigarette smoke (CS) exposure combined with intraperitoneal injection extract (CSE). The modeling efficiency evaluated lung function...

1. GBD Chronic Respiratory Disease Collaborators. Prevalence and attributable health burden of chronic respiratory diseases, 1990-2017: a systematic analysis for the Global Burden Study 2017. Lancet Respir Med. 2020;8(6):585-596. doi:10.1016/S2213-2600(20)30105-3 CrossRef Google Scholar

With this study, we aimed to explore the clinical features, laboratory examinations, imaging and severe predictors of Chlamydia psittaci pneumonia identify disease early, shorten course illness, improve prognosis. We retrospectively reviewed data 39 patients diagnosed with non-psittacosis community-acquired at Third Xiangya Hospital Central South University from December 2018 April 2021. collected remaining medical serum analyze cytokines that are associated disease-related inflammation....

Chronic obstructive pulmonary disease (COPD) is a multi-pathogenesis chronic lung disease. The mechanisms underlying COPD have not been adequately illustrated. Many reseachers argue that microRNAs (miRs) could play crucial role in COPD. classic animal model of both time consuming and costly. This study proposes novel mice explores the miR-21 A total 50 wide-type (WT) C57BL/6 were separated into five euqlly-sized groups-(1) control group (CG), (2) combined method (NCM, cigarette smoke (CS)...

MicroRNAs and autophagy play important roles in chronic obstructive pulmonary disease (COPD). This study was designed to explore the role of microRNA-21 (miR-21) induced COPD. Using C57BL/6, miR-21−/− mice human bronchial epithelial (16HBE) cell line, we found that lung tissues mice, level COPD model group significantly higher than control group. However, compared model, lower CSE+CS In miR-21 overexpressed. Moreover, cells exposed cigarette smoke extract (CSE), expression upregulated...

Abstract To analyze the clinical characteristics of re-positive discharged COVID-19 patients and find distinguishing markers. The demographic features, symptoms, laboratory results, comorbidities, co-infections, treatments, illness severities chest CT scan results 267 were collected from 1st January to 15th February 2020. was diagnosed by RT-PCR. Clinical symptoms nucleic acid test during 14 days post-hospitalization quarantine. 30 out detected Re-positive could not be distinguished or...

Abstract Chronic obstructive pulmonary disease (COPD) is a complex with multiple etiologies, while smoking the most established one. The present study investigated modulation of T-helper 17 (Th17) cell differentiation by miR-21/Smad7/TGF-β pathway, and their roles in COPD. Lung tissues were obtained from lung cancer patients or without COPD who underwent lobotomy levels miR-21, TGF-β/Smad signaling molecules, RORγT, other Th17-related cytokines detected. Mouse models built exposing both...

The present study aimed to investigate the protective role of sirtuin 1 (SIRT1) and oxygen regulated protein 150 (ORP150) in a rat COPD model by inducing changes ER stress apoptosis. We separated 48 Sprague Dawley (SD) rats into four groups randomly: control group, resveratrol group intervention group. Rats were challenged with cigarette smoke lipopolysaccharide (a selective activator SIRT1). lung functions measured recorded. expression levels SIRT1 ORP150 tissues examined western blot RTq...

<title>Abstract</title> Small airway remodeling is widely recognized as one of the major pathological changes 11 in chronic obstructive pulmonary disease (COPD), yet underlying mechanisms remain 12 unclear. In present study, we observed higher levels epithelial-mesenchymal transition 13 (EMT) and increased collagen deposition lungs both COPD patients mice 14 models compared to control group. Additionally, exposure cigarette smoke extract 15 (CSE) led an upregulation TGF-β1 secretion...

Pneumonia, a leading cause of morbidity and mortality worldwide, often necessitates Intensive Care Unit (ICU) admission. Accurate prediction pneumonia is crucial for tailored prevention treatment plans. However, existing models face limited adoption in clinical practice due to their lack interpretability.

Chronic obstructive pulmonary disease (COPD) is a prevalent, incurable condition requiring lifelong management. Inadequate daily management exacerbates COPD, leading to increased healthcare utilization and reduced quality of life. This study aimed design validate 10-item COPD self-evaluation (COPD-ES) questionnaire apply it in the education stable patients. Participants were recruited from Third Xiangya Hospital Central South University randomly assigned control intervention groups. The...

Abstract Background: To analyze the clinical characteristics of re-positive discharged COVID-19 patients and find markers to distinguish them. Methods： The demographic features, symptoms, laboratory results, comorbidities, co-infections, treatments, illness severities chest CT scan results 267 were collected during 1st January 15th February 2020. was diagnosed by RT-PCR. subsequent symptoms nucleic acid test obtained 14 days post-hospitalization quarantine. Results: 30 out detected...

Ventricular escape beat is one of the most serious diseases arrhythmia, which usually happen in patients that suffer coronary heart disease, myocarditis and myocardial infaction. It has essential clinical significance to find ventricular promptly exactly. This paper proposes a method identification, based on wavelet transform BP neural network, benefit intelligent systems ECG monitoring with an efficacious solution. After selecting characteristics signals MIT-BIH database using transform,...

Passive localization based on Time Difference Of Arrival (TDOA) has attracted more attention because of its simple equipment and high positioning accuracy. UAV cluster with mobility security repeatedly appeared in modern battlefields plays an important role passive positioning. This paper focuses the solution algorithms single emitter target by TDOA. Firstly, some improved methods Chan algorithm Taylor are simulated presence sensor locating errors. Then a new method particle swarm...

In this paper, a semi-physical simulation platform and ADS are used to acquire the signals of three types specific emitters, then high-order spectral analysis variational modal decomposition extract features signals. The phase noise oscillator bias voltage power amplifier as independent variables study their influence on features, based which correlation is carried out. Regression fitting performed with significant obtain regression function, feature-weighted support vector machine...

The M2 macrophage, functionally characterized as inflammation-dissolving, tissue-remodeling and fibrillation-promoting, are generally considered to take part in all process of the development occurrence chronic obstructive pulmonary disease (COPD). Studies suggest that macrophage can lead emphysema via IL-17a, IFN-γ CCL18.Moreover, they accelerate inflammation dissolving by adjusting level many mediates.Meanwhile, also influence synthesis MMPs stimulation TGF-β signaling, causing small...