A5020586231- MicroRNA in disease regulation
- Autophagy in Disease and Therapy
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neonatal Respiratory Health Research
- Advanced Proteomics Techniques and Applications
- Cancer-related molecular mechanisms research
- Congenital Diaphragmatic Hernia Studies
- Advanced Glycation End Products research
- RNA modifications and cancer
- Bioinformatics and Genomic Networks
- Extracellular vesicles in disease
- Biomedical Text Mining and Ontologies
- Circular RNAs in diseases
- Hydrogen's biological and therapeutic effects
- Gene expression and cancer classification
- Respiratory Support and Mechanisms
- Cannabis and Cannabinoid Research
- Toxoplasma gondii Research Studies
- Machine Learning in Bioinformatics
Third Xiangya Hospital
2018-2023
Central South University
2018-2023
Hunan University
2023
Tianma Microelectronics (China)
2023
Chronic obstructive pulmonary disease (COPD) is a multi-pathogenesis chronic lung disease. The mechanisms underlying COPD have not been adequately illustrated. Many reseachers argue that microRNAs (miRs) could play crucial role in COPD. classic animal model of both time consuming and costly. This study proposes novel mice explores the miR-21 A total 50 wide-type (WT) C57BL/6 were separated into five euqlly-sized groups-(1) control group (CG), (2) combined method (NCM, cigarette smoke (CS)...
MicroRNAs and autophagy play important roles in chronic obstructive pulmonary disease (COPD). This study was designed to explore the role of microRNA-21 (miR-21) induced COPD. Using C57BL/6, miR-21−/− mice human bronchial epithelial (16HBE) cell line, we found that lung tissues mice, level COPD model group significantly higher than control group. However, compared model, lower CSE+CS In miR-21 overexpressed. Moreover, cells exposed cigarette smoke extract (CSE), expression upregulated...
It is well known that the lipotoxic mechanism of palmitic acid (PA), a main constituent triglyceride, dependent on reactive oxygen species (ROS). Recently, it has also been reported PA an autophagy inducer. However, causal association and underlying induced ROS in toxicity remain unclear. The present study demonstrates for first time PA-induced enhances generation via activating calcium ion/protein kinase Cα/nicotinamide adenine dinucleotide phosphate oxidase 4 (Ca2+/PKCα/NOX4) pathway human...
Abstract Chronic obstructive pulmonary disease (COPD) is a complex with multiple etiologies, while smoking the most established one. The present study investigated modulation of T-helper 17 (Th17) cell differentiation by miR-21/Smad7/TGF-β pathway, and their roles in COPD. Lung tissues were obtained from lung cancer patients or without COPD who underwent lobotomy levels miR-21, TGF-β/Smad signaling molecules, RORγT, other Th17-related cytokines detected. Mouse models built exposing both...
Abstract The number of biological databases is growing rapidly, but different use identifiers (IDs) to refer the same entity. inconsistency in IDs impedes integration various types data. To resolve problem, we developed MantaID, a data-driven, machine learning–based approach that automates identifying on large scale. MantaID model’s prediction accuracy was proven be 99%, and it correctly effectively predicted 100,000 ID entries within 2 min. supports discovery exploitation from quantities...
Autophagy is a regulatory mechanism that packages damaged organelles, proteins, and pathogens to form vesicles transports lysosomes for degradation, enabling the recycle of useful components. Therefore, autophagy plays an important role in biological growth regulation homeostasis. In past two decades, growing evidence has shown microRNA (miRNA) closely related autophagy. MiRNA-21 promotes or inhibits via regulating relevant pathways different downstream target genes, tumors,...
Chronic obstructive pulmonary disease (COPD) is a characterized by persistent airflow restriction. This study aims to explore whether there endothelial-to-mesenchymal transition (EndMT) in COPD mice and the relationship between microRNA-21 (miR-21) EndMT.
To explore the effects of miR-21 on macrophage autophagy, proliferation and apoptosis induced by cigarette smoke extract (CSE). Methods: The cells was divided into a control group, CSE interventine group (CSE group), inhibitor+CSE intervention (miR-21 group). expression in 3 groups detected real-time PCR. inhibitor were Western blot, MTT assay flow cytometry. Results: Compared with levels autophagy significantly increased (both P<0.05). lower than that (P<0.05). expressions microtubule...