A5042200176- Gut microbiota and health
- Probiotics and Fermented Foods
- Caveolin-1 and cellular processes
- Bone and Dental Protein Studies
- Cancer Cells and Metastasis
- dental development and anomalies
- Protein Hydrolysis and Bioactive Peptides
- Dental Trauma and Treatments
- Hedgehog Signaling Pathway Studies
- Lipid metabolism and disorders
- Genetics and Neurodevelopmental Disorders
- Fibroblast Growth Factor Research
- Liver physiology and pathology
- Genetic and Kidney Cyst Diseases
- Macrophage Migration Inhibitory Factor
- Biochemical Analysis and Sensing Techniques
- Skin and Cellular Biology Research
- Congenital Diaphragmatic Hernia Studies
- Dietary Effects on Health
- Immune cells in cancer
- Ferroptosis and cancer prognosis
- Medicinal Plants and Bioactive Compounds
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal motility and disorders
- Pancreatic and Hepatic Oncology Research
University of California, Los Angeles
2024-2025
Washington University in St. Louis
2018-2024
National Institute of Arthritis and Musculoskeletal and Skin Diseases
2016
National Institutes of Health
2016
The colonic epithelium can undergo multiple rounds of damage and repair, often in response to excessive inflammation. responsive stem cell that mediates this process is unclear, part because a lack vitro models recapitulate key epithelial changes occur vivo during repair. Here, we identify Hopx+ colitis-associated regenerative (CARSC) population functionally contributes mucosal repair mouse colitis. CARSCs, enriched for fetal-like markers, transiently arose from hypertrophic crypts known...
Tooth enamel is the hardest substance in human body and has a unique combination of hardness fracture toughness that protects teeth from dental caries, most common chronic disease worldwide. In addition to high mineral content, tooth comprises organic material important for mechanical performance influences initiation progression caries; however, protein composition not been fully characterized. Here, we determined epithelial hair keratins, which are crucial maintaining integrity sheaths...
ABSTRACT Patients with tricho-dento-osseous (TDO) syndrome, an ectodermal dysplasia caused by mutations in the homeodomain transcription factor DLX3, exhibit enamel hypoplasia and hypomineralization. Here we used a conditional knockout mouse model to investigate developmental molecular consequences of Dlx3 deletion dental epithelium vivo. resulted formation chalky hypomineralized all teeth. Interestingly, transcriptomic analysis revealed that major matrix proteins proteases known be involved...
Two biological activities of butyrate in the colon (suppression proliferation colonic epithelial stem cells and inflammation) correlate with inhibition activity histone deacetylases. Cellular biochemical studies molecules similar structure to butyrate, but different molecular details (functional groups, chain-length, deuteration, oxidation level, fluorination, or degree unsaturation), demonstrated that these were sensitive structure, compatible hypothesis acts by binding Zn2+ catalytic site...
The Cancer Genome Atlas (TCGA) project has identified HER2 mutations or amplification in 7% of colon cancers. In addition to mutations, cancer patients also possess co-occurring genes such as APC. Here, we investigated the role and APC on crypt-villus architecture intestinal epithelium, localization secretory cells, expression stem cell markers. We generated a transgenic mouse (HER2V777L Tg) possessing an activating mutation commonly found colorectal patients, HER2V777L, using transcription...
Abstract The local microenvironment shapes macrophage differentiation in each tissue. We hypothesized that the peritoneum, factors addition to retinoic acid can support GATA6-driven and function of peritoneal large cavity macrophages (LCMs). found soluble proteins produced by mesothelial cells lining maintained GATA6 expression cultured LCMs. Analysis global gene isolated highlighted mesothelin (Msln) its binding partner mucin 16 (Muc16) as candidate secreted ligands potentially regulate...
Recent advances in human genetics have shed light on the genetic factors contributing to inflammatory diseases, particularly Crohn's disease (CD), a prominent form of bowel disease. Certain risk genes associated with CD directly influence cytokine biology and cell-specific communication networks. Current therapies primarily rely anti-inflammatory drugs, which are inconsistently effective lack strategies for promoting epithelial restoration mucosal balance. To understand CD's underlying...
Two biological activities of butyrate in the colon (suppression proliferation colonic epithelial stem cells and inflammation) correlate with inhibition histone deacetylases. Cellular biochemical studies molecules similar structure to butyrate, but different molecular details (functional groups, chain-length, deuteration, oxidation level, fluorination, or degree unsaturation) demonstrated that these were sensitive structure, compatible hypothesis acts by binding Zn 2+ catalytic site...
Two biological activities of butyrate in the colon (suppression proliferation colonic epithelial stem cells and inflammation) correlate with inhibition histone deacetylases. Cellular biochemical studies molecules similar structure to butyrate, but different molecular details (functional groups, chain-length, deuteration, oxidation level, fluorination, or degree unsaturation) demonstrated that these were sensitive structure, compatible hypothesis acts by binding Zn<sup>2+</sup>...