A5067328767- Aldose Reductase and Taurine
- SARS-CoV-2 and COVID-19 Research
- CRISPR and Genetic Engineering
- Viral gastroenteritis research and epidemiology
- Diet, Metabolism, and Disease
- Cassava research and cyanide
- RNA and protein synthesis mechanisms
- Heme Oxygenase-1 and Carbon Monoxide
- COVID-19 Clinical Research Studies
- Epigenetics and DNA Methylation
- Biochemical effects in animals
- Respiratory viral infections research
- Inflammasome and immune disorders
- Folate and B Vitamins Research
- Pluripotent Stem Cells Research
- Viral Infections and Immunology Research
Ankara University
2018-2021
Ribavirin is a guanosine analog with broad-spectrum antiviral activity against RNA viruses. Based on this, we aimed to show the anti-SARS-CoV-2 of this drug molecule via in vitro, silico, and molecular techniques. showed Vero E6 cells following SARS-CoV-2 infection, whereas itself did not any toxic effect over concentration range tested. In silico analysis suggested that ribavirin has impact SARS-CoV-2, acting at different viral proteins. According detailed techniques, was shown decrease...
Abstract Ribavirin is a guanosine analog and has broad-spectrum antiviral activity against RNA viruses. Based on this, we aimed to show the anti-SARS-CoV-2 of this drug molecule via in vitro, silico molecular techniques. showed Vero E6 cells following SARS-CoV-2 infection. In analysis suggested that Ribarivin impact cells. According detailed techniques, was shown decrease TMPRSS2 expression both at mRNA protein level 48 hours after treatment. The suppressive effect ACE2 be dependent cell...
Abstract Heme oxygenase-1 (HO-1) is a stress-induced enzyme that catalyzes the breakdown of heme into biliverdin, carbon monoxide, and iron. Targeting HO-1 to treat severe COVID-19 has been suggested by several groups, yet role in SARS-CoV-2 infection remains unclear. Based on this, we aimed investigate antiviral activity Hemin, an activator HO-1. Infectivity was decreased Vero E6 cells treated with Hemin. Hemin also TMPRSS2 ACE2 mRNA levels non-infected cells, possibly explaining observed...
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