Ebru Kocakaya
A5013407113- SARS-CoV-2 and COVID-19 Research
- Computational Drug Discovery Methods
- Bioinformatics and Genomic Networks
- Machine Learning in Bioinformatics
- Respiratory viral infections research
- Viral Infections and Immunology Research
- Viral gastroenteritis research and epidemiology
- Inflammasome and immune disorders
- RNA and protein synthesis mechanisms
- Turkish Literature and Culture
- Linguistics and Cultural Studies
- COVID-19 Clinical Research Studies
- Microbial Metabolic Engineering and Bioproduction
- Protein Structure and Dynamics
- Cultural and Sociopolitical Studies
- Heme Oxygenase-1 and Carbon Monoxide
Ankara University
2020-2021
We need to effectively combine the knowledge from surging literature with complex datasets propose mechanistic models of SARS-CoV-2 infection, improving data interpretation and predicting key targets intervention. Here, we describe a large-scale community effort build an open access, interoperable computable repository COVID-19 molecular mechanisms. The Disease Map (C19DMap) is graphical, interactive representation disease-relevant mechanisms linking many sources. Notably, it computational...
Ribavirin is a guanosine analog with broad-spectrum antiviral activity against RNA viruses. Based on this, we aimed to show the anti-SARS-CoV-2 of this drug molecule via in vitro, silico, and molecular techniques. showed Vero E6 cells following SARS-CoV-2 infection, whereas itself did not any toxic effect over concentration range tested. In silico analysis suggested that ribavirin has impact SARS-CoV-2, acting at different viral proteins. According detailed techniques, was shown decrease...
Abstract We describe a large-scale community effort to build an open-access, interoperable, and computable repository of COVID-19 molecular mechanisms - the Disease Map. discuss tools, platforms, guidelines necessary for distributed development its contents by multi-faceted biocurators, domain experts, bioinformaticians, computational biologists. highlight role relevant databases text mining approaches in enrichment validation curated mechanisms. Map their relevance pathophysiology...
Abstract Ribavirin is a guanosine analog and has broad-spectrum antiviral activity against RNA viruses. Based on this, we aimed to show the anti-SARS-CoV-2 of this drug molecule via in vitro, silico molecular techniques. showed Vero E6 cells following SARS-CoV-2 infection. In analysis suggested that Ribarivin impact cells. According detailed techniques, was shown decrease TMPRSS2 expression both at mRNA protein level 48 hours after treatment. The suppressive effect ACE2 be dependent cell...
Abstract Heme oxygenase-1 (HO-1) is a stress-induced enzyme that catalyzes the breakdown of heme into biliverdin, carbon monoxide, and iron. Targeting HO-1 to treat severe COVID-19 has been suggested by several groups, yet role in SARS-CoV-2 infection remains unclear. Based on this, we aimed investigate antiviral activity Hemin, an activator HO-1. Infectivity was decreased Vero E6 cells treated with Hemin. Hemin also TMPRSS2 ACE2 mRNA levels non-infected cells, possibly explaining observed...