A new sesquiterpene benzoxazole, nakijinol B (3), its acetylated derivative, diacetate (6), and two quinones, smenospongines (4) C (5), were isolated from the methanol extract of marine sponge Dactylospongia elegans. Also known compounds dactyloquinone a 1:1 mixture ilimaquinone 5-epi-ilimaquinone. Their structures determined on basis spectroscopic analyses comparison with literature data. The assessed for their cytotoxicity against panel human tumor cell lines (SF-268, H460, MCF-7, HT-29)...

The crude EtOH extract of an Echinodictyum sp. collected during trawling operations in the Great Australian Bight, Australia, displayed antibacterial and antiparasitic properties. Bioassay-directed fractionation yielded three novel sulfonic acids, echinosulfonic acids A to C (1-3), a new sulfone, echinosulfone (4). Structures were assigned these compounds on basis detailed spectroscopic analysis. It was determined that A-C (1-3) (4) contributed but not activity extract.

In search of new antimalarial compounds, three phenolic glycosides, robustasides E (1), F (2), and G (3), in addition to the known compounds robustaside D (4) quercetin-7-O-[α-l-rhamnopyranosyl(1→6)-β-d-galactopyranoside] (5), were identified during chemical investigations MeOH extract from leaves twigs Grevillea "Poorinda Queen". The structures elucidated through 2D NMR spectroscopy, while absolute configuration sugar was degradation comparison with an authentic standard. Discussed detail...

Three new merosesquiterpenoids, metachromins U, V, and W (1-3), were isolated from a specimen of the marine sponge Thorecta reticulata collected off Hunter Island, Tasmania, Australia. Structures compounds elucidated through extensive NMR investigations comparison with literature values. The cytotoxicities 1-3 assessed against panel human tumor cell lines (SF-268, H460, MCF-7, HT-29) mammalian line (CHO-K1). All found to have 50% growth inhibition activities in range 2.1-130 μM, 2 being most...

A Sigmosceptrella sp. from the Great Australian Bight, Australia, has yielded new norditerpene cyclic peroxide, nuapapuin (2a), and norsesterterpene peroxide sigmosceptrellin D (3a), characterized as corresponding methyl esters 2b 3b. The crude methylated sponge extract also E ester (4). Relative stereochemistry about C2, C3, C6 was assigned by established empirical rules absolute advanced Mosher procedure. plausible biosynthetic pathway been proposed that rationalizes key transformations in...

Bioassay-directed fractionation of the ethanol extracts two Amphimedon spp. collected during trawling operations in Great Australian Bight yielded four new macrocyclic lactone/lactams, amphilactams A−D (1−4). The possess potent vitro nematocidal properties, and their structures were assigned on basis detailed spectroscopic analysis comparison with synthetic model compounds. feature both carbon skeletons an enamino lactone/lactam moiety unprecedented natural products literature.

Ricinus communis (also know as the castor bean plant) whose forbears escaped from suburban gardens or commercial cultivation grow wild in many countries. In temperate and tropical climates seeds will develop to maturity, plants may be perennial. Australia these have become widespread are regarded noxious weeds localities. The of R. contain ricin, a protein toxin which can easily extracted into an aqueous solution. Ricin is toxic by ingestion, inhalation, injection. history terrorist...

Investigations were undertaken to ascertain the appropriateness of studying metabolome Ricinus communis for cultivar and provenance determination. Seeds from 14 R. specimens (a total 56 seeds) collected east coast Australia analyzed by high pressure liquid chromatography with UV detection (HPLC-UV), chromatography–mass spectrometry (LC-MS), 1H NMR spectroscopy. The data then using principle component analysis (PCA). For HPLC-UV analysis, six unambiguously identified PCA as belonging separate...

Bioassay-guided fractionation of extracts the brown alga Sporochnus comosus led to isolation five new compounds, comosusols A−D (3−6) and comosone A (7). The structures all isolated compounds were elucidated using standard one- two-dimensional NMR techniques, as well comparison with literature values. cytotoxic activity was investigated against a panel human tumor mammalian cell lines. These assays found eight nine had GI50 values in 8−63 μM range.

The methanol extract of an assemblage Halimeda stuposa and a Dictyota sp., yielded three natural products characteristic one sp. These included the xenicane diterpene 4-hydroxydictyolactone (1), diterpenes dictyol E (2), 8a,11-dihydroxypachydictyol A (3) indole-3-carboxaldehyde (4). minor revision 1 new spectroscopic data for 2 are provided, along with associated anti-cancer activities compounds.

While investigating the cytotoxic activity of methanol extract an Australian marine sponge Stelletta sp. (Demospongiae), a new diketopiperazine, cyclo-(4-S-hydroxy-R-proline-R-isoleucine) (1), was isolated together with known bengamides; A (2), F (3), N (4), Y (5), and bengazoles; Z (6), C(4) (7) C(6) (8). The isolation structure elucidation diketopiperazine 1-8 against panel human mammalian cell lines are discussed.

Seeds of Ricinus communis contain the toxic protein ricin, a 64 kD heterodimeric type II ribosome-inactivating that has been used in several high-profile poisoning incidents. The ability to determine which cultivar toxin was isolated from via an LC-MS method would be significant use law enforcement and forensic agencies.To analyse chemometrics (principal components analysis (PCA), orthogonal partial-least-squares discriminant (OPLS-DA)) extracts R. identify compounds specific particular...

Investigation of a southern Australian marine sponge, Mycale sp., resulted in isolation the known norsesterterpenes 1−3 as well two new isomeric norsesterterpenes, mycaperoxide C methyl ester (4) and D (5), six norterpenes (6−11).

Chemical investigations of the crude MeOH extract Physalis viscosa led to identification novel acylated sucrose ester physaloside A (1). The structure 1 was determined by 2D NMR analysis, and absolute configuration chemical degradation comparison with authentic standards.

Investigation of two southern Australian marine sponges, Mycale spp., resulted in isolation the known norsesterterpene mycaperoxide F methyl ester (5) together with a new G (10) and norterpene ketone 11. All structures were secured by spectroscopic analysis chemical derivatization. The absolute stereochemistry previously assigned to 5 application Horeau procedure has been revised Mosher procedure.

A Latrunculia sp. collected off Port Phillip Bay, Victoria, returned three new norsesterterpene cyclic peroxides. Trunculins G (9), H (10) and I (11) were isolated as their methyl esters (12), (13) (14) respectively. Gross structures for these trunculins assigned on the basis of spectroscopic analysis, while absolute stereochemistry about peroxide terminus was established by application Horeau Mosher procedures.