A5046545518- Microbial Inactivation Methods
- Microfluidic and Bio-sensing Technologies
- 3D Printing in Biomedical Research
- Magnetic and Electromagnetic Effects
- Boron Compounds in Chemistry
- Plasma Applications and Diagnostics
- Infectious Diseases and Mycology
- Polyamine Metabolism and Applications
- Ultrasound and Cavitation Phenomena
- Viral Infectious Diseases and Gene Expression in Insects
- Electrostatic Discharge in Electronics
- Neuroscience and Neural Engineering
- Plant tissue culture and regeneration
- Food composition and properties
- Transgenic Plants and Applications
- Electrochemical Analysis and Applications
- Cassava research and cyanide
- Anodic Oxide Films and Nanostructures
- Advanced Machining and Optimization Techniques
- Machine Learning in Materials Science
- Electrohydrodynamics and Fluid Dynamics
- Nanowire Synthesis and Applications
- Toxin Mechanisms and Immunotoxins
- Nanocomposite Films for Food Packaging
- Nuclear Physics and Applications
University of Buenos Aires
2010-2023
Fundación Ciencias Exactas y Naturales
2010-2023
Consejo Nacional de Investigaciones Científicas y Técnicas
2015-2023
Institute of Astronomy and Space Physics
2023
Instituto de Física de Buenos Aires
2022
Centro Científico Tecnológico - San Juan
2015-2019
We present experimental measurements and theoretical predictions of ion transport in agar gels during reversible electroporation (ECT) for conditions typical to many clinical studies found the literature, revealing presence pH fronts emerging from both electrodes. These results suggest that are immediate substantial. Since they might give rise tissue necrosis, an unwanted condition applications ECT as well irreversible (IRE) electrogenetherapy (EGT), it is important quantify their extent...
Treatments based on electroporation (EP) induce the formation of pores in cell membranes due to application pulsed electric fields. We present experimental evidence existence pH fronts emerging from both electrodes during treatments tissue EP, for conditions found many studies, and that these are immediate substantial. indirectly measured through evanescence time (ET), defined as required buffer neutralize them. The ET was a indicator imaged at series intervals using four-cluster hard...
Electropermeabilization (EP) based protocols such as those applied in medicine, food processing or environmental management, are well established and widely used. The voltage, tissue electric conductivity, of utmost importance for assessing final electropermeabilized area thus EP effectiveness. Experimental results from literature report that, under certain protocols, consecutive pulses increase conductivity even the permeabilization amount. Here we introduce a theoretical model that takes...
Nasal cavity tumors are usually diagnosed late, when they already have infiltrated adjacent tissues thus requiring very aggressive treatments with serious side effects. Here we use electrochemotherapy (ECT), a well demonstrated treatment modality for superficial tumors.In the case of deep-seated tumors, main limitation ECT is reaching tumor an appropriate electric field. To overcome this introduce single needle electrode (SiNE), minimally invasive device that can deliver field simple...
Boron neutron capture therapy (BNCT) combines preferential tumor uptake of 10B compounds and irradiation. Electroporation induces an increase in the permeability cell membrane. We previously demonstrated optimization boron biodistribution microdistribution employing electroporation (EP) decahydrodecaborate (GB-10) as carrier a hamster cheek pouch oral cancer model. The aim present study was to evaluate if EP could improve control without enhancing radiotoxicity BNCT vivo mediated by GB-10...
Abstract Background Electrochemotherapy (ECT), a medical treatment widely used in human patients for tumor treatment, increases bleomycin toxicity by 1000 fold the treated area with an objective response rate of around 80%. Despite its high rate, there are still 20% cases which not responding. This could be ascribed to fact that bleomycin, when administered systemically, is reaching whole mass properly because characteristics vascularization, case local administration cover areas unreachable...
A case of a canine oral eosinophilic granuloma in 14-year-old female crossbred is described. The dog was presented with history ptyalism, halitosis, local pain, decreased appetite, and blood staining noted on food water bowls. Clinical, hematologic, biochemical examinations, abdominal ultrasonography, 3-view chest radiographs were performed, no metastases found. Histopathologic examination two 6 mm punch biopsies from the lesion revealed presence granulomatous lesions submucosa. After...
Currently, increasing amounts of pulsed electric fields (PEF) are employed to improve a person's life quality. This technology is based on the application shortest high voltage electrical pulse, which generates an increment over cell membrane permeability. When applying these pulses, unwanted effect electrolysis, could alter treatment. work focused study local variations field and current density around bubbles formed by electrolysis water PEF how electroporation protocol. The assays, in...
Background: Electrochemotherapy is a novel tumor treatment routinely used for cutaneous and subcutaneous tumors in human patients the European Union since 2006. Here we it to treat an amelanotic melanoma of root tongue canine patient. Case Presentation: The patient was 9 year-old, female, Golden Retriever, dehydrated, cachectic bad general condition due difficulty eating drinking provoked by tumor. procedure performed with anesthesia, intravenous administration bleomycin, went uneventful....