A5046616473- Diabetes Management and Research
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Diabetes Treatment and Management
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Diabetes Management and Education
- Sphingolipid Metabolism and Signaling
- Adrenal Hormones and Disorders
- Medical Education and Admissions
- Health and Wellbeing Research
- Sexual Differentiation and Disorders
- Mobile Health and mHealth Applications
- Congenital Anomalies and Fetal Surgery
- Hip disorders and treatments
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Acute Kidney Injury Research
- Prenatal Screening and Diagnostics
- Diversity and Career in Medicine
- Cannabis and Cannabinoid Research
- Chronic Kidney Disease and Diabetes
- Diet, Metabolism, and Disease
- Innovations in Medical Education
- Williams Syndrome Research
- Parkinson's Disease Mechanisms and Treatments
- Genetics and Neurodevelopmental Disorders
University of Cincinnati Medical Center
2019-2024
Cincinnati Children's Hospital Medical Center
2015-2024
Aarhus University Hospital
2024
University of Cincinnati
2015-2024
Cincinnati VA Medical Center
2020
Hyattsville Community Development Corporation
2018
Abstract Turner syndrome (TS) affects 50 per 100 000 females. TS multiple organs through all stages of life, necessitating multidisciplinary care. This guideline extends previous ones and includes important new advances, within diagnostics genetics, estrogen treatment, fertility, co-morbidities, neurocognition neuropsychology. Exploratory meetings were held in 2021 Europe United States culminating with a consensus meeting Aarhus, Denmark June 2023. Prior to this, eight groups addressed areas...
This study evaluated the effects of continuous glucose monitoring (CGM) combined with family behavioral intervention (CGM+FBI) and CGM alone (Standard-CGM) on glycemic outcomes parental quality life compared blood (BGM) in children ages 2 to <8 years type 1 diabetes.This was a multicenter (N = 14), 6-month, randomized controlled trial including 143 youth age diabetes. Primary analysis included treatment group comparisons percent time range (TIR) (70-180 mg/dL) across follow-up...
Background An increase in newly diagnosed type 1 diabetes (T1D) has been posited during the COVID-19 pandemic, but data are conflicting. We aimed to determine trends T1D and severity of presentation at diagnosis for pediatric adolescent patients (2020) as compared previous year (2019) a multi-center analysis across United States. Methods This retrospective study from seven centers Exchange Quality Improvement Collaborative (T1DX-QI) included on new onset proportion DKA January December 31,...
Abstract Context Multiple autosomal recessive genes have been etiologically linked to primary adrenal insufficiency (PAI). Recently, sphingosine-1-phosphate lyase 1 (SGPL1) gene mutations were recognized as a cause of steroid-resistant nephrotic syndrome type 14 (NPHS14), sphingolipidosis with multisystemic manifestations, including PAI. Objective To check if SGPL1 are involved in the pathogenesis PAI patients who do not exhibit syndrome. Methods Sequencing 21 familial glucocorticoid disease...
The purpose of this study is to examine timing meal insulin and further determine whether an association exists between missed doses. cohort included 4768 T1D Exchange clinic registry participants <26 years with type 1 diabetes ≥1 year. Chi-square tests, t-tests, regression were used assess the relationship participant characteristics doses, respectively. Timing doses was analyzed using logistic regression. In all, 21% reported administering several minutes before, 44% immediately 10%...
Turner syndrome is a chromosomal abnormality in which there complete or partial absence of the X chromosome. effects 1 every 2000 live births. Short stature cardinal feature Syndrome and standard treatment recombinant human growth hormone. When hormone started at an early age normal adult height can be achieved. With delayed diagnosis young women with may not reach height. Adjuvant therapy oxandrolone used but no consensus on optimal timing treatment, duration long term adverse treatment....
Abstract Objectives Turner syndrome (TS) is a complex and chronic medical condition that requires lifelong subspecialty care. Effective transition preparation needed for successful transfer from pediatric to adult care in order avoid lapses care, explore health issues such as fertility, prepare caregivers adolescents take over responsibility their own The objective of this study was evaluate accuracy knowledge personal history screening guidelines young adults (AYA) with TS. Methods This...
<b><i>Introduction:</i></b> Adult women with Turner syndrome (TS) have a high prevalence of diabetes and β-cell dysfunction that increases morbidity mortality, but it is unknown if there present in youth TS. This study aimed to determine the TS impact traditional therapies on insulin sensitivity (SI) secretion. <b><i>Methods:</i></b> Cross-sectional, observational recruited 60 girls healthy controls (HC) matched pubertal status. Each subject...
Iatrogenic hypoglycemia is a prominent barrier to achieving optimal glycemic control in patients with diabetes, part due dampened counterregulatory hormone responses. It has been demonstrated that elevated liver glycogen content can enhance these hormonal responses through signaling the brain via afferent nerves, but role plays this effect remains unclear. During first 4 h of each study, dogs was increased by using an intraportal infusion fructose stimulate hepatic glucose uptake (HG; n =...
Youth with type 1 diabetes (T1D) require 24/7 access to T1D management supplies. This study aims characterize supplies when youth are away from home. We emailed a comprehensive survey 4756 parents of Exchange participants &lt;18 years old; 752 respondents completed the (83% by parents). Results were age-stratified: &lt;6 (N=21), 6-12 (N=271) and 13-18 (N=459). The majority carry rapid-acting insulin most time or always, yet proportion decreases as age increases (Table 1). ≥80%...
Several studies have associated the presence of residual insulin secretion capability (also referred to as being C-peptide positive) with lower risk insulin-induced hypoglycemia in patients type 1 diabetes (T1D), although reason is unclear. We tested hypothesis that infusion would enhance glucagon response hyperinsulinemia during euglycemic and hypoglycemic conditions dogs (5 male/4 female). After a 2-hour basal period, an intravenous (IV) was started, dextrose infused maintain euglycemia...
Urinary (U) neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) are markers of renal tubular injury. Whether NGAL KIM-1 elevated in early diabetic disease (DKD) is not known. We performed a pilot study to compare the U concentrations (C) YA with T1D or T2D from SEARCH registry healthy controls (n 45 each group). The diabetes were selected based on age at dx &gt; 10 years duration &gt;8 randomly across quartiles eGFR similar age, gender ethnicity....
Fasting is associated with increased susceptibility to hypoglycemia in people type 1 diabetes, thereby making it a significant health risk. To date, the relationship between fasting and insulin-induced has not been well characterized, so our objective was determine whether insulin-independent factors, such as counterregulatory hormone responses, are adversely impacted by healthy control individuals. Counterregulatory responses were measured 12 during 2 metabolic studies. During one study,...
Background and Aims. The optimal basal bolus insulin distribution in type 1 diabetes (T1D) is still controversial. Herein, we aimed to determine the variability of total daily dose according treatment modality technologies from Better Control Pediatric Adolescent Diabetes: Working Create Centers Reference (SWEET) registry. Methods. study cohort was generated by using SWEET database. Patients with T1D for at least 2 years, aged between 2.5 18 one clinic visit June 2010 2021, were included...
<b>Objective: </b>This study evaluated the effects of continuous glucose monitoring (CGM) combined with family behavioral intervention (CGM+FBI) and CGM alone (Standard-CGM) on glycemic outcomes parental quality life compared blood (BGM) in children ages 2 to <8 years type 1 diabetes <p><b>Research Design Methods: </b>A multicenter (N=14), 6-month, randomized controlled trial including 143 youth age diabetes. Primary analysis included treatment group...
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More than 5700 children with diabetes attend American Diabetes Association (ADA) camps each year. Training volunteer medical staff has become more challenging given the rapid advances in technology. Through a prospective, multi-site pilot study at 4 ADA camps, we assessed efficacy of an educational bundle online interactive cases in-situ simulation preparing volunteers for management type 1 (T1D). We hypothesized that our curriculum would reduce workload necessary to manage T1D as measured...
<b>Objective: </b>This study evaluated the effects of continuous glucose monitoring (CGM) combined with family behavioral intervention (CGM+FBI) and CGM alone (Standard-CGM) on glycemic outcomes parental quality life compared blood (BGM) in children ages 2 to <8 years type 1 diabetes <p><b>Research Design Methods: </b>A multicenter (N=14), 6-month, randomized controlled trial including 143 youth age diabetes. Primary analysis included treatment group...