Soluble α-Klotho (s-Klotho) is a circulating protein with pleiotropic effects that mainly induce protective effects. Our study investigates the associations between s-Klotho and several established inflammatory biomarkers, aim of examining whether levels are representative states.A total 11,128 eligible participants from NHANES 2007-2016 were included in our study. Levels four uric acid (UA), C-reactive (CRP), white blood cell (WBC) count, mean platelet volume (MPV), examined for their...

Abstract Background The abrupt onset of the COVID-19 pandemic compelled universities to swiftly establish online teaching and learning environments that were not only immediately deployable but also conducive high-quality education. This study aimed compare effectiveness synchronous asynchronous formats in dermatology lecture for undergraduate medical students, including academic performance, self-efficacy, cognitive load. Methods A total 170 fourth-year students attending included. was...

Recommendations in current guidelines on the use of calf circumference (CC) as a diagnostic measure sarcopenia is conflicting. In this study, we incorporated CC into conventional models and compared their predictive scores mortality.To clarify capacity CC-added establish correlation with mortality risk.From National Health Nutrition Examination Survey 1999-2002, 2,532 participants aged 50-85 comprising 51.7% male were included.Our definitions contained four sarcopenic components, low (C),...

Diets for healthy aging have long been an intriguing issue. The current study makes a head-to-head comparison of four dietary patterns and their associations with soluble Klotho (s-Klotho) levels, aging-related marker. data 7906 subjects were obtained from the National Health Nutrition Examination Survey 2007−2016. Each participant was given score or grouped according to patterns, namely Mediterranean adherence diet (MDS), low-carbohydrate-diet score, low-fat diet, low-carbohydrate diet....

Abstract Background: Shared decision-making (SDM) is becoming more popular in various medical specialties as a core component of patient-centered care. However, patients’ lack sufficient disease knowledge remains barrier to implementing SDM. Objectives: This study aims examine the effectiveness two educational approaches for atopic dermatitis (AD) patients, pamphlet and plus video, using assessments level satisfaction. Methods: From August 2021 February 2023, patients with AD from...

Background: In the wake of emerging development biologics in atopic dermatitis (AD), herpes zoster (HZ) infection has been reported as a treatment-related adverse event. Objectives: This study aims at investigating association between AD and HZ, risk factors within. Methods: 28,677 participants with from Taiwan National Health Insurance Research Database 2000–2015 were enrolled. Risk HZ was compared cohort (with AD) control (without AD). Further analyses conducted gender-, age-, treatment...

Vitamin (Vit) D plays a vital role in human health, and the prevalence of Vit deficiency worldwide has been rising concern. This study investigates serum 25-hydroxy-Vit [25(OH)D] status healthy US civilians identifies how two main sources, sun exposure dietary intake, determine final 25(OH)D levels individuals.A total 2,360 participants from The National Health Nutrition Examination Survey (NHANES) 2009-2014 were analyzed. We divided intake all subjects into 10 strata gave score ranging 1 to...

Benzo[a]pyrene (BaP), a toxic carcinogen, is associated with various adverse effects but rarely discussed in muscle-related disorders. This study investigated vitro and vivo triggered by BaP exposure muscles hypothesized that might induce conditions similar to sarcopenia due the shared mechanism of oxidative stress. In experiments used C2C12 mouse myoblasts examine induced control (untreated) BaP-treated (10 µM/ml) muscle cells. An established TNF-α-treated model was utilized verify our...

Metabolic syndrome (MetS) brings considerable effects on cognitive function, but trajectories within remain unclear. We investigated the interactions between distinct MetS components and domains. A total of 5693 participants from Taiwan biobank during 2008–2018 were enrolled. Participants classified as either normal or having at two time points; i.e., study entry follow-up. At both points, evaluations using Mini-Mental State Examination (MMSE) conducted. The hazard ratios (HRs) mild...

Abstract Background Helicobacter pylori ( H. ), Gram negative microaerophilic bacteria, is a well-known pathogen of many gastrointestinal diseases. But several emerging evidences suggest it role in numerous other extra-gastric The current study investigates the relationship between infection and sarcopenia, clinical condition characterized by loss mass function skeletal muscle. A total 3453 eligible participants from Third National Health Nutrition Examination Survey (NHANES III), United...

Protective effects of superficial subcutaneous adipose tissue 1 (SAT) are widely discussed. 3-5As several lines evidence related to central obesity (a high percentage VAT) support the association with a higher risk for diseases and mortality, 6 role VAT's counterpart, SAT, has raised great interest.Previous studies suggested that SAT actually protects from cardiometabolic disorders such as diabetes, 7 hypertriglyceridemia, 8 atherosclerosis. 9Basic science on mice offered more robust adverse...

Abstract Background and Objectives The interplay between muscle brain lacks a holistic approach to assess the combined effect of multiple factors. This study utilizes clustering analysis identify health patterns their relationships with various magnetic resonance imaging (MRI) indices. Research Design Methods Two hundred seventy-five cognitively intact participants who completed MRI from Health, Aging, Body Composition Study were enrolled. Muscle health-related markers that showed...

Abstract Background The soluble receptor for advanced glycation end products (sRAGE) has been proposed to serve as a marker disease severity, but its role in sarcopenia, an age-related progressive loss of muscle mass and function, remains elusive. This study examines the association between sRAGE sarcopenia. Methods A total 314 community-dwelling elderly adults who had their health examination at Tri-Service General Hospital from 2017 2019 underwent protein analysis with enzyme-linked...

A genome-wide association study (GWAS) of sarcopenia unraveled the importance genetic contribution to decline in muscle. The current investigated sarcopenia-related single nucleotide polymorphisms (SNPs) Asian older adults, and further constructed a genotype score that tests combined effect these SNPs on risk sarcopenia.Ninety-six subjects aged 60 or above were recruited from database annual geriatric health examination at Tri-Service General Hospital during 2020. Eligible criteria included:...

The association between sarcopenia and metabolic syndrome (MetS) has been well established. Nevertheless, the transition process normal low muscle mass (LMM) states effect of this on MetS less explored. Our study here examined whether direction toward or away from LMM alters risks MetS. Initially, gene set enrichment analysis confirmed that correlates with at genetic level. Subsequently, 6476 eligible participants older than 60 years were enrolled 2010 2016 Tri-Service General Hospital,...