A5016482769- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Glioma Diagnosis and Treatment
- Developmental Biology and Gene Regulation
- Tryptophan and brain disorders
- Tumors and Oncological Cases
- Renal and related cancers
- Autoimmune Bullous Skin Diseases
- Genetic Neurodegenerative Diseases
- Patient-Provider Communication in Healthcare
- Pregnancy and Medication Impact
- Chronic Lymphocytic Leukemia Research
- Urticaria and Related Conditions
- Genetic and rare skin diseases.
- Chromatin Remodeling and Cancer
- Empathy and Medical Education
- Drug-Induced Adverse Reactions
- Thyroid Cancer Diagnosis and Treatment
- Bone health and treatments
- Pluripotent Stem Cells Research
- Innovative Teaching Methods
- Eosinophilic Disorders and Syndromes
- Melanoma and MAPK Pathways
- Asthma and respiratory diseases
- Dermatological and Skeletal Disorders
National Defense Medical Center
2018-2025
Tri-Service General Hospital
2017-2025
Washington University in St. Louis
2013-2025
National Taiwan University
2025
Memorial Hospital
2024
St. Martin de Porres Hospital
2016-2020
Kaohsiung Medical University
2015-2019
Kaohsiung Medical University Chung-Ho Memorial Hospital
2019
Pingtung Hospital
2016
Ministry of Health and Welfare
2016
Abstract Background The abrupt onset of the COVID-19 pandemic compelled universities to swiftly establish online teaching and learning environments that were not only immediately deployable but also conducive high-quality education. This study aimed compare effectiveness synchronous asynchronous formats in dermatology lecture for undergraduate medical students, including academic performance, self-efficacy, cognitive load. Methods A total 170 fourth-year students attending included. was...
Tandem duplications involving the BRAF kinase gene have recently been identified as most frequent genetic alteration in sporadic pediatric glioma, creating a novel fusion protein (f-BRAF) with increased activity. To define role of f-BRAF gliomagenesis, we demonstrate that regulates neural stem cell (NSC), but not astrocyte, proliferation and is sufficient to induce glioma-like lesions mice. Moreover, f-BRAF-driven NSC results from tuberin/Rheb-mediated mammalian target rapamycin (mTOR)...
The availability of human pluripotent stem cells (hPSCs) and progress in genome engineering technology have altered the way we approach scientific research drug development screens. Unfortunately, procedures for editing hPSCs often subject to harsh conditions that compromise viability: a major problem is compounded by innate challenge single-cell culture. Here describe generally applicable workflow supports cloning expansion after sorting. Stem-Flex RevitaCell supplement, combination with...
Pediatric low-grade gliomas (LGGs) frequently do not engraft in immunocompromised mice, limiting their use as an experimental platform. In contrast, murine Neurofibromatosis-1 ( Nf1 ) optic LGG stem cells (o-GSCs) form glioma-like lesions wild-type, but athymic, mice following transplantation. Here, we show that the inability of athymic to support o-GSC engraftment results from impaired microglia/macrophage function, including reduced expression Ccr2 and Ccl5, both which are required for...
Sodium-glucose cotransporter-2 inhibitors (SGLT2i), a novel class of antidiabetic medications, have emerged as key treatment option for diabetes management. Notably, SGLT2i promote glucose and sodium excretion through urine, mechanism that may be implicated in the potential association between use atopic dermatitis (AD) risk. This study investigated relationship new-onset AD diabetic patients. nationwide active-comparator cohort utilized data from Taiwan National Health Insurance Database to...
Cells in the pluripotent ground state can give rise to somatic cells and germ cells, acquisition of pluripotency is dependent on expression Nanog. Pluripotency conserved primitive ectoderm embryos from mammals urodele amphibians, here we report isolation a Nanog ortholog axolotls (axNanog). axNanog does not contain tryptophan repeat domain expressed as monomer axolotl animal cap. The monomeric form sufficient regulate mouse embryonic stem but dimers are required rescue LIF-independent...
The availability of adult malignant glioma stem cells (GSCs) has provided unprecedented opportunities to identify the mechanisms underlying treatment resistance. Unfortunately, there is a lack comparable reagents for study pediatric low-grade (LGG). Leveraging neurofibromatosis 1 (Nf1) genetically engineered mouse LGG model, we report isolation CD133+ multi-potent (LG-GSCs), which generate glioma-like lesions histologically similar parent tumor following injection into immunocompetent hosts....
Neurofibromatosis type 1 (NF1) is a common neurodevelopmental disorder caused by impaired function of the neurofibromin RAS regulator. Using combination Nf1 genetically engineered mice and pharmacological/genetic inhibition approaches, we report that differentially controls neural stem cell (NSC) proliferation multilineage differentiation through selective use PI3K/AKT RAF/MEK pathways. While governs neurofibromin-regulated NSC proliferation, MEK-dependent. Moreover, whereas MEK-regulated...
Purpose: To investigate the morphological and functional outcome of refractory large macular hole (MH) with autologous neurosensory retinal free flap transplantation. Methods: This case series enrolled 10 patients suffering from MH at Kaohsiung Medical University Hospital, Kaohsiung, Taiwan. All eyes underwent pars plana vitrectomy, a 1.5 to 2-MH diameter was harvested. We used an adhesive agent such as whole blood or Viscoat assist stabilization then use tamponade silicone oil vitreous...
Importance Immune checkpoint inhibitors (ICIs) are recognized as revolutionary cancer therapies but have raised concerns about immune-related adverse events, including the development of autoimmune diseases. Objective To evaluate psoriasis risk associated with use ICIs in patients cancer. Design, Setting, and Participants This nationwide cohort study a target trial emulation design used data from Taiwan National Health Insurance database Cancer Registry. The participants included were who...
The aims of this study were to investigate the cancer incidence and risk in HIV/AIDS patients relative general population Taiwan.Using Taiwan's National Health Insurance Research Database, 15,269 identified between 1998 2009. Gender-specific densities (IDs) both AIDS-defining cancers (ADC) non-AIDS-defining (NADC) after HIV infection calculated. Age-, sex-, period-adjusted standardized rates (SIRs) obtained using 1.8 million people from as controls.A total 1117 male 165 female diagnosed with...
Abstract Background: Shared decision-making (SDM) is becoming more popular in various medical specialties as a core component of patient-centered care. However, patients’ lack sufficient disease knowledge remains barrier to implementing SDM. Objectives: This study aims examine the effectiveness two educational approaches for atopic dermatitis (AD) patients, pamphlet and plus video, using assessments level satisfaction. Methods: From August 2021 February 2023, patients with AD from...
Selenium has been shown to sustain the growth of selected human hepatocellular carcinoma cell lines under serum-free conditions, but detailed mechanism remained undetermined. In present study, molecular mechanism(s) involving sodium selenite (Na2SO3, Se) as a survival agent were determined. Selenite not only protects HuH7 cells from serum deprivation-induced apoptosis, it also supports its long-term in (10(-7)m) supplemented medium. The anti-apoptotic effect correlates with activation focal...
// Yi-Hsien Chen 1 , Patrick J. Cimino 2 Jingqin Luo 3 Sonika Dahiya David H. Gutmann Department of Neurology, Washington University School Medicine, St. Louis, MO, USA Pathology, Surgery, Correspondence to: Gutmann, e-mail: gutmannd@neuro.wustl.edu Keywords: glioblastoma, ER stress, brain tumor, glioma stem cell, apoptosis Received: September 29, 2015 Accepted: February 25, 2016 Published: March 10, ABSTRACT The overall survival for adults with malignant (glioblastoma) remains poor despite...
The number of men who have sex with (MSM) infected HIV-1 in Taiwan has increased rapidly the past few years. goal this study was to conduct a molecular epidemiological infection among MSM identify risk factors for intervention. Voluntary counseling program and anonymous testing were provided patrons at 1 gay bar, 7 night clubs 3 saunas Taipei New Cities 2012. subtypes determined using gag subtype-specific PCR phylogenetic analysis by env sequences. Recent LAg-Avidity EIA. In-depth interviews...