A5110367939- Drug Transport and Resistance Mechanisms
- Algal biology and biofuel production
- Metabolism, Diabetes, and Cancer
- Pharmacological Effects of Natural Compounds
- Epilepsy research and treatment
- Traditional Chinese Medicine Studies
- Ion channel regulation and function
- Pharmacological Effects and Toxicity Studies
- Natural product bioactivities and synthesis
- Dermatology and Skin Diseases
- Natural Antidiabetic Agents Studies
- Medical Research and Treatments
- Cardiac electrophysiology and arrhythmias
- Neuroscience and Neuropharmacology Research
- Healthcare and Venom Research
- Diet, Metabolism, and Disease
- Barrier Structure and Function Studies
- Bioactive natural compounds
- Sunflower and Safflower Cultivation
- Adenosine and Purinergic Signaling
- Antibiotics Pharmacokinetics and Efficacy
- Cancer Mechanisms and Therapy
- Thallium and Germanium Studies
- Cardiovascular Syncope and Autonomic Disorders
- Regional Development and Environment
National Defense Medical Center
2020-2025
China Ocean Shipping (China)
2024
Minda Hospital
2024
Northeast Normal University
2020-2024
Anhui University
2024
Guangdong Pharmaceutical University
2012-2024
People 's Liberation Army 451 Hospital
2023
National Taiwan Normal University
2023
Ministry of Health and Welfare
2023
Hunan Cancer Hospital
2021
Sodium-glucose cotransporter-2 inhibitors (SGLT2i), a novel class of antidiabetic medications, have emerged as key treatment option for diabetes management. Notably, SGLT2i promote glucose and sodium excretion through urine, mechanism that may be implicated in the potential association between use atopic dermatitis (AD) risk. This study investigated relationship new-onset AD diabetic patients. nationwide active-comparator cohort utilized data from Taiwan National Health Insurance Database to...
Introduction Drug monotherapy was inadequate in controlling blood glucose levels and other comorbidities. An agent that selectively tunes multiple targets regarded as a new therapeutic strategy for type 2 diabetes. Acanthopanax trifoliatus (L.) Merr polysaccharide (ATMP) is bio-macromolecule isolated from has potential diabetes management due to its anti-hyperglycemia activity. Methods Type mellitus induced mice using streptozotocin, 40 80 mg/kg ATMP administered daily via the intragastric...
Abstract Background Acute postoperative pain plays an important role in the perioperative neurocognitive disorders (PND). The pathogenesis of PND is still unknown, but it generally believed that peripheral and central nervous system inflammation play role, acute also thought to aggravate inflammatory response. aim present study explore effect on related cognitive impairment behaviour elderly rats after surgery. Methods Rats were assigned into four groups: control, surgery for internal...
Considering the impact of differences in watershed characteristics on river water quality, with Chaohu Lake Basin as research object, based data meteorology, topography, soil, and remote sensing images monitoring points from October 2019 to September 2020, unit at each point was divided through digital terrain analysis, comprehensive landscape were explored use correlation redundancy multiple regression analysis investigate influence units (including land use, climate, etc.) quality rivers...
Background: Acanthopanax trifoliatus (L.) Merr. is a medicinal plant found in Southeast Asia, and its young leaves shoots are consumed as vegetable. The main bioactive components of this herb polysaccharides that have significant anti-diabetic effects. aim study was to evaluate the immunoregulatory effect A. polysaccharide (ATMP) on mouse model type 1 diabetes mellitus (T1DM). Methods: monosaccharide composition mean molecular mass ATMP were determined by HPLC HPGPC. T1DM induced mice using...
Background: Melanoma is considered as one of the most aggressive and deadliest cancers current targeted therapies melanoma often suffer limited efficacy or drug resistance. Discovery novel multikinase inhibitors anti-melanoma candidates still needed. Methods: In this investigation, we assessed in vitro vivo activities SC-535, which a small molecule inhibitor discovered by us recently. We analyzed inhibitory effects SC-535 on various cell lines human umbilical vascular endothelial cells...
Melanoma is a type of cancer arising from the melanocytes, which are cells that make up pigment melanin and derived neural crest. There no particularly effective therapy once disease metastatic, highlighting need for discovery novel potent agents. In this investigation, we adopted zebrafish embryonic pigmentation model to identify antimelanoma agents by screening an in-house small molecule library. With assay, found compound, SKLB226, blocked cell migration. Mechanism action studies showed...
Abstract This study addressed the hypothesis that cardiac Sirtuin 1 (Sirt1) deficiency alters cardiomyocyte Ca 2+ and Na + regulation, leading to dysfunction arrhythmogenesis. We used mice with cardiac‐specific Sirt1 knockout (Sirt1 −/− ). flox/flox were served as control. showed impaired ejection fraction increased ventricular spontaneous activity burst firing compared those in control mice. The arrhythmic events suppressed by KN93 ranolazine. Reduction transient amplitudes sarcoplasmic...
Cementing is a critical link in oil and gas exploitation, which slurry density control particularly important. In this study, we examined mixing system order to solve the problem of time delays system. The model was built accordance with system’s structure. A Smith fuzzy PID (proportion integration differentiation) composite solution proposed herein, simulation results show that adjustment overshoot are lower than those conventional predictive compensation control. genetic algorithm utilized...