Brain-derived neurotrophic factor (BDNF), a member of the nerve growth (NGF)-related family neutrophins, promotes survival and differentiation cultured nigral dopamine neurons. Two-week infusions BDNF were made above right pars compacta substantia nigra in adult rats. Systemic injection these animals with (+)-amphetamine, dopamine-releasing drug, induced 3 or 4 body rotations per minute directed away from infusion site. Neither supranigral NGF nor neocortical rotational behavior. injections...

Research Article| September 01, 2001 Construction of a pluton: Evidence from an exposed cross section the Searchlight pluton, Eldorado Mountains, Nevada Carolyn A. Bachl; Bachl 1Department Geology, Vanderbilt University, Nashville, Tennessee 37235, USA Search for other works by this author on: GSW Google Scholar Calvin F. Miller; Miller Jonathan S. 2Department San Jose State Jose, California 95192-0102, James E. Faulds 3Nevada Bureau Mines and University Nevada, Reno, 89557, Author Article...

Zircons from the Devils Kitchen rhyolite in Pleistocene Coso Volcanic field, California have been analyzed by situ Pb/U ion microprobe (SHRIMP-RG) and detailed cathodoluminescence imaging. The zircons yield common-Pb-corrected disequilibrium-corrected 206Pb/238U ages that predate a previously reported K–Ar sanidine age up to 200 kyr, range of exhibited is also approximately kyr. Cathodoluminescence imaging indicates formed contrasting environments. Most are euhedral, majority weakly zoned,...

Investigation of the Coso Range using seismicity, gravity, and geochemistry rocks fluids, supports interpretation that structure hosting geothermal resource is a nascent metamorphic core complex. The structural setting releasing bend in dextral strike-slip system extends from Indian Wells Valley northward into Owens Valley. This tectonic results NW-directed transtension, which accommodated by normal faulting brittle upper 4–6 km crust, shearing ductile stretching below this depth,...

The Akt - GSK3 signaling pathway has been recently implicated in psychostimulant-induced behavioral and cellular effects. Here, the ability of cocaine to regulate activity was investigated by measuring phosphorylation states two kinases. anatomical specificity response determined, as contributions dopamine NMDA receptors actions cocaine. As found be increased cocaine, subsequent experiments importance activation conditioned reward. Adult male CD-1 mice were injected with or saline, levels...

Research Article| December 01, 1995 Geochronologic and isotopic evidence for Triassic-Jurassic emplacement of the eugeoclinal allochthon in Mojave Desert region, California Jonathan S. Miller; Miller 1Department Geology, University North Carolina at Chapel Hill, 27599-3315 Search other works by this author on: GSW Google Scholar Allen F. Glazner; Glazner J. Douglas Walker; Walker 2Isotope Geochemistry Laboratory, Department Kansas, Lawrence, Kansas 66045 Mark W. Martin Author Article...

Research Article| August 01, 2000 A Sr, Nd, and Pb isotopic study of mantle domains crustal structure from Miocene volcanic rocks in the Mojave Desert, California Jonathan S. Miller; Miller 1Department Geology, University North Carolina, Chapel Hill, Carolina 27599-3315, USA Search for other works by this author on: GSW Google Scholar Allen F. Glazner; Glazner G. Lang Farmer; Farmer 2CIRES Department Geological Sciences, Colorado, Boulder, Colorado 80309, Ismail B. Suayah; Suayah Lori A....

Abstract The Tuolumne Batholith (TB), Sierra Nevada (USA), is an archetypal large, zoned arc intrusion ( c . 1200 km 2 ). Previous work proposed that compositional zonation observed in the TB was produced in-situ by inward differentiation of a large magma chamber and/or large-scale, intrachamber mixing. Recent geochronology shows intruded over 8–9 Ma, making single pulse fractionation or mixing dimensions unlikely. We examine processes responsible for variation Cathedral Peak Granodiorite,...

Any architectural optimization aims at satisfying the end user. However, modern architectures execute with little to no knowledge about individual If could determine whether their users are satisfied, they provide higher efficiency; improved reliability, reduced power consumption, increased security, and a better user experience. A major reason for this limitation is input devices. Specifically, traditional devices (e.g., mouse keyboard) limited information In paper, we make case addition of...

How long does it take to form a large granitic pluton, and how are plutons related in time space magma chambers their erupted products? These questions at the heart of spirited ongoing debate crustal igneous petrology community over reconcile field observations

Abstract The Mono Craters are an overlapping chain of at least 28 domes and coulees located south Lake, east central California, represent the most recent eruptions high‐silica rhyolite magma in Lake‐Long Valley volcanic region. Regionally widespread tephra fall deposits from serve as important chronostratigraphic markers for correlations late Quaternary terrestrial archives western United States. A well‐resolved eruption chronology is thus not only critical hazard considerations but also...

Studies of plutons indicate that they are the result a complex interplay magmatic processes occurring during magma generation, ascent, and emplacement. A critical tool for deciphering these is high-precision geochronology, which can help determine timing rates magmatism in crust. We conducted field U-Pb geochronological study Cretaceous Black Peak intrusive North Cascades Washington State to investigate at detailed scale refine estimates plutonic construction rates. High-precision chemical...