A5054209601- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Cancer Genomics and Diagnostics
- Neutropenia and Cancer Infections
- Acute Lymphoblastic Leukemia research
- Sepsis Diagnosis and Treatment
- Immune Cell Function and Interaction
- Cytomegalovirus and herpesvirus research
- Childhood Cancer Survivors' Quality of Life
- Chronic Myeloid Leukemia Treatments
- Cancer Immunotherapy and Biomarkers
- Gene expression and cancer classification
- T-cell and B-cell Immunology
- Lymphoma Diagnosis and Treatment
- Fungal Infections and Studies
- Blood groups and transfusion
- Blood disorders and treatments
- CAR-T cell therapy research
- Polyomavirus and related diseases
- Digital Imaging for Blood Diseases
- Antifungal resistance and susceptibility
- Machine Learning in Healthcare
- Platelet Disorders and Treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Lung Cancer Research Studies
Essen University Hospital
2016-2025
University Hospitals of the Ruhr-University of Bochum
2023-2025
Ruhr University Bochum
2023-2025
University of Duisburg-Essen
2018-2025
Cancer Research Center
2025
Artificial Intelligence in Medicine (Canada)
2025
Sheffield Teaching Hospitals NHS Foundation Trust
2024
St. James's Hospital
2024
Universitätsklinik Marien Hospital Herne
2024
West German Heart and Vascular Center Essen
2021-2023
Double umbilical cord blood (DUCB) transplantation is an accepted strategy for patients without suitable human leukocyte antigen (HLA) matched donors. However, DUCB associated with increased morbidity and mortality because of slow recovery immunity a high risk infection. To define the differences in immune reconstitution between HLA unrelated donor (MUD) transplantation, we performed detailed, prospective analysis 42 recipients 102 filgrastim-mobilized peripheral stem cell recipients....
Abstract Balanced rearrangements involving the KMT2A gene ( r) are recurrent genetic abnormalities in acute myeloid leukemia (AML), but there is lack of consensus regarding prognostic impact different fusion partners. Moreover, implications mutations co-occurring with r not established. From HARMONY AML database 205 adult patients were selected, 185 whom had mutational information by a panel-based next-generation sequencing analysis. Overall survival (OS) was similar across translocations,...
Platelet reconstitution after allogeneic hematopoietic cell transplantation (allo‐HCT) is heterogeneous and influenced by various patient‐ transplantation‐related factors, associated with poor prognoses for graft function (PGF) isolated thrombocytopenia. Tailored interventions could improve the outcome of patients PGF post‐HCT To provide individual predictions 180‐day platelet counts from early phase data, we developed a model long‐term allo‐HCT. A large cohort ( n = 1949) adult undergoing...
Abstract Quantification of neutrophil counts is the most relevant assessment cellular immunity in clinical practice. Patients with neutropenia are considered at risk and categorized according to its severity. The incidence febrile varies, but patients acute myeloid leukemia traditionally high risk, especially following myelotoxic treatments. To provide additional functional parameters, we investigated ex vivo migration properties morphology neutrophils 10 using single-cell video-microscopy...
Abstract Even in the era of PCR‐based monitoring, prophylaxis, and preemptive therapy, Cytomegalovirus (CMV) viremia remains a relevant cause non‐relapse mortality (NRM) after allogeneic hematopoietic cell transplantation (HCT). However, studies using binary analysis (presence/absence CMV) reported contradicting data for NRM, overall survival leukemia relapse. Here, we analyzed CMV replication kinetics 11 508 whole blood PCR samples 705 patients with HCT between 2012 2017. Using two...
Patients with hematologic disease are at high risk of morbidity and mortality from COVID-19 due to disease-inherent therapy-related immunodeficiency. Whether infection the SARS-CoV2 omicron variant leads attenuated severity in these patients is currently unknown.
Cytomegalovirus (CMV) reactivation is a frequent complication after allogeneic hematopoietic cell transplantation (HCT), whose impact on clinical outcome, in particular leukemic relapse, controversial. We retrospectively analyzed 687 HCT recipients with acute myeloid leukemia (AML) and ciclosporin-based immunosuppression to better understand the differential of CMV transplant outcomes depending AML disease stage vivo T depletion antithymocyte globulin (ATG). Without ATG, associated...
Allogeneic hematopoietic stem cell transplantation (HSCT) recipients frequently develop acute respiratory failure (ARF) with pulmonary infiltrates. Molecular- and biomarker-based assays enhance pathogen detection, but data on their yield in this population are scarce. This was a retrospective single-center study of 156 consecutive HSCT admitted to the intensive care unit (ICU) between May 2013 July 2017. Findings from microbiologic diagnostic workup using currently available methods...
Abstract Allogeneic hematopoietic cell transplantation (HCT) effectively treats high‐risk hematologic diseases but can entail HCT‐specific complications, which may be minimized by appropriate patient management, supported accurate, individual risk estimation. However, almost all HCT scores are limited to a single assessment before without incorporation of additional data. We developed machine learning models that integrate both baseline data and time‐dependent laboratory measurements...
Introduction Anti-T-lymphocyte globulin (ATG) or post-transplant cyclophosphamide (PTCy) prevent graft-versus-host disease (GVHD) after hematopoietic cell transplantation (HCT), yet individual patients benefit differentially. Methods Given the sparse comparative data on impact of cellular immune reconstitution in this setting, we studied flow cytometry and clinical outcomes 339 recipients 10/10 matched-unrelated donor (MUD) HCT using either ATG (n=304) PTCy (n=35) for vivo T manipulation...
Onco-hematological studies are increasingly adopting statistical mixture models to support the advancement of genomically-driven classification systems for blood cancer. Targeting enhanced patients stratification based on sole role molecular biology attracted much interest and contributes bring personalized medicine closer reality. In onco-hematology, Hierarchical Dirichlet Mixture Models (HDMM) have become one preferred method cluster genomics data, that include presence or absence gene...
Prophylaxis of graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (HCT) remains challenging. Because prospective randomized trials in-vivo T depletion using anti-T-lymphocyte globulin (ATLG) in addition to a calcineurin inhibitor and methotrexate (MTX) led conflicting outcome results, we evaluated the impact ATLG on clinical outcome, lymphocyte- immune reconstitution survival models. In total, 1500 consecutive patients with hematologic malignancies...
Abstract Chronic graft-vs-host-disease (cGvHD) is the most relevant long-term complication after allogeneic stem cell transplantation (HSCT) with major impact on non-relapse mortality, but data intensive care unit (ICU) outcome are missing. In this retrospective, multicenter study we analyzed 174 adult HSCT recipients cGvHD requiring treatment. Skin, pulmonary, liver, and intestinal involvement were present in 76.7%, 47.1%, 38.1% 24.1%, respectively, a total of 63.2% had severe cGvHD. Main...
Predictive models can support physicians to tailor interventions and treatments their individual patients based on predicted response risk of disease help in this way put personalized medicine into practice. In allogeneic stem cell transplantation assessment is be enhanced order respond emerging viral infections reactions. However, develop predictive it necessary harmonize integrate high amounts heterogeneous medical data that stored different health information systems. Driven by the demand...
Immunosuppressive therapy (IST) with horse anti-thymocyte globulin (hATG) and cyclosporine (CsA) is considered one of the first-line therapies in patients (pts) acquired aplastic anemia (AA).In our single-center, retrospective analysis response rates (RRs) to ATG/CsA at a minimum 6 mo were evaluated 67 treatment-naïve (TN) AA pts (52.2% (35/67) females; median age 45 y (range 18-89 y)) being treated West German Cancer Center Department Hematology University Hospital Essen between April 2000...
Aim: This real-world analysis evaluated docetaxel plus nintedanib in patients with advanced pulmonary adenocarcinoma after chemotherapy and immune checkpoint inhibitor failure, for whom treatment options are limited. Methods: Data were sourced retrospectively from seven German centers. Results: Of 93 patients, overall response rate was 41.4% (disease control rate: 75.9%). 57 given third-line nintedanib, 50.0% 82.7%). Median survival following 8.4 months. Adverse events consistent the known...
Invasive aspergillosis involving patients with neutropenia or severe immunosuppression, such as hematologic malignancies is associated high mortality. Patients T-cell large granular lymphocytic leukemia (T-LGL) on the other hand are considered to be less vulnerable for opportunistic fungal infection their course of disease chronic and marked by violent cytopenia then in e.g. Aplastic Anemia. Only regarded independent risk factor T-LGL patients. We report a case 53 year old patient T-LGL,...
Acute graft-versus-host disease (aGvHD) is a major cause of death for patients following allogeneic hematopoietic stem cell transplantation (HSCT). Effective management moderate to severe aGvHD remains challenging despite recent advances in HSCT, emphasizing the importance prophylaxis and risk factor identification.