A5049809949- Multiple Myeloma Research and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Platelet Disorders and Treatments
- Hemophilia Treatment and Research
- Immunotherapy and Immune Responses
- Venous Thromboembolism Diagnosis and Management
- Chronic Lymphocytic Leukemia Research
- Education, Psychology, and Social Research
- Glycosylation and Glycoproteins Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Monoclonal and Polyclonal Antibodies Research
- Chronic Myeloid Leukemia Treatments
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Blood Coagulation and Thrombosis Mechanisms
- Acute Myeloid Leukemia Research
- Atrial Fibrillation Management and Outcomes
- T-cell and B-cell Immunology
- Cancer Treatment and Pharmacology
- Systemic Lupus Erythematosus Research
- Blood disorders and treatments
- Immunodeficiency and Autoimmune Disorders
- Hepatitis C virus research
- Botany and Plant Ecology Studies
- Protease and Inhibitor Mechanisms
Masaryk University
2006-2024
University Hospital Brno
2008-2023
Miroslav Krleža Institute of Lexicography
2019
St. Anne's University Hospital Brno
2018
Faculty (United Kingdom)
2015
Ocní klinika
1997-2010
General University Hospital in Prague
2009
München Klinik
2008
Institute of Forest Ecology of the Slovak Academy of Sciences
1980-1985
University of Agriculture Faisalabad
1973-1977
A new method of sap flow rate determination in stems adult trees is described which mass (the transpiration flux the present case) estimated from a heat-transfer measurement. The device used includes couple thermometers differential connection and plate electrodes, through controlled heat input flows into denned studied segment xylem. was tested first with laboratory simulating system, then stem living treePrunus avium L. data are registered continually automatically; continuous measurement...
The analysis of the dynamic properties thermal methods transpiration flow measurement was performed and measuring system developed, capable quantitative measurements fast changes (in minutes). is specified with a constant automatically maintained temperature difference between heated reference points in measured part plant. System's output signal related to quantity linear. has been under longterm testing full grown trees using method heat balance direct electric heating xylem. results...
Primary plasma cell leukemia (PCL) is the most aggressive monoclonal gammopathy. It was formerly characterized by ≥ 20% circulating cells (CTCs) until 2021, when this threshold decreased to 5%. We hypothesized that primary PCL not a separate clinical entity, but rather it represents ultra-high-risk multiple myeloma (MM) elevated CTC levels.We assessed levels of CTCs multiparameter flow cytometry in 395 patients with newly diagnosed transplant-ineligible MM establish cutoff for identifies...
Sap flow rate and transpiration dynamics were studied in the course of 3 years a dominant tree species floodplain forest,i.e. full-grown oak (Quercus robur L.) tree, using method trunk heat balance devised by authors. The investigations carried out at period which regular marked fluctuation relatively high water table usually occurred, culminating seasonal flooding. High sap values established under conditions non-limiting supply soil (up to 400 kg per day or up 39 000 vegetation period)...
Identifying haemophilia patients with inhibitors for clinical trials is difficult due to the limited number of available. Registries are therefore being established as an additional means data collection. The aim this study was investigate effect different recombinant activated factor VII (rFVIIa; NovoSeven dose ranges and dosing schedules on incidence re-bleeding in inhibitors. In retrospective, uncontrolled study, bleeding patterns adult high responding were analysed. Only from Czech...
Several improvements of the method sap flow rate determination in full-grown trees elaborated by authors are described. The is based on heat balance with direct electrical heating xylem. accuracy relationship for calculation was improved, influence unevennesses different annual rings reduced. A extrapolation results obtained measuring an individual xylem segment against whole tree and interpolation to a unit elaborated, simplified connecting electrodes supplying thermal input described...
Sap flow rate (Qw) and leaf water potential (Ψw.leaf) in adult specimens of birch (Betula) oak (Quercus) were measured under contrasting soil moisture conditions (Ψw.sofl). With sufficient Qw reached about 250 cm3h−1 calculated per unit tree-trunk segment as given by 1 cm length its circumference. In water-stress (when Ψw.leaf = −15 × 105Pa), stopped transpiration wilted. Oak transpired even when fell below −20 105Pa. The relation between was always linear with various Ψw.soil differed the...
Our aim was to establish whether the pretreatment levels of angiogenesis activators and inhibitors can be used predict clinical responses treatment that included high-dose chemotherapy with peripheral stem cell support.<br />We analyzed samples outcomes 96 patients MM enrolled in CMG 2002 randomized trial treated induction support. Concentrations vascular endothelial growth factor (VEGF), hepatocytar (HGF), basic fibroblastic (bFGF), thrombospondin-1 (TSP-1), endostatin, angiostatin were...
Urokinase (uPA) plays an essential role in the activation of plasminogen to plasmin, and together with its receptor (uPAR), tissue activator (tPA) urokinase inhibitors (PAI 1, PAI 2, 3 protease nexin) forms system (PAS), a component metastatic cascade importantly contributing invasive growth angiogenesis malignant tumours. In our project we examined expression uPA, uPAR, 1 2 tumor also studied plasma levels before after initiation therapy patients colorectal carcinoma relationship grade...
Controversies still exist regarding definition of the thrombotic risks in Ph- (BCR/ABL1-) myeloproliferative disorders with thrombocythemia (MPD-T). Platelet counts at diagnosis are currently not taken as a risk factor thrombosis. In our cohort 1179 patients MPD-T, prospectively registered for anagrelide treatment, we found that median platelet count prior to event was significantly higher than time points without any ensuing thrombosis (453 vs. 400 × 10(9)/L, P < 0.001), albeit tended be...
Microparticles are small membrane fragments with dimension between 0.1 and 1 μm, which released during cell activation or apoptosis, exposing the phospholipid phosphatidylserine antigens typical for cellular origin. Philadelphia-negative myeloproliferative neoplasms (MPNs) characterized by an increased risk of thrombosis. Data from literature suggest association thrombosis procoagulant activity microparticles. Association microparticles incidence was assesed in a group 126 patients MPNs....
Urokinase (uPA) is a serine protease, which together with uPAR, tPA, PAI 1 and 2 forms the plasminogen activator system, component of metastatic cascade contributing to invasive growth angiogenesis malignant tumours.Both preceding therapy after 6-8 weeks treatment, plasma levels (photometric microplate method on ELISA) uPA, tissue expression (immunohistochemical reaction) were analysed from 80 colorectal carcinoma patients.Analysis showed higher pre-treatment in patients advanced tumours,...
The course of the transpiration flow rate (Qw), acceleration (Qw/dt) and integrated was determined during an average summer day by repeated measurements according to method heat balance free water capacity tree trunk estimated. relations between temperature relative humidity air vapour pressure deficit measured at same time in their diurnal course, as well single terms whole which were carried out correlation analysis. problems linked with effect various meteorological conditions different...
Summary. FEIBA ® (factor eight inhibitor by‐passing activity) is used to achieve haemostasis in haemophiliacs with inhibitor. The aim of this study was evaluate efficacy and consumption the product treatment haemorrhages factor VIII inhibitor, determine factors that can influence results treatment. We data from our haemophilia centre years 2000–2008. Six were treated on demand for 61 bleeding episodes (45 haemarthroses, six muscle bleeds, other sites bleeds four multiple bleeds). median...
Summary Plasma cell leukaemia (PCL) is a rare and very aggressive plasma disorder. Preventing dismal outcome of PCL requires early diagnosis with appropriate analytical tools. Therefore, the investigation 33 patients primary secondary was done when quantity circulating cells (PCs) using flow cytometry (FC) morphology assessment evaluated. The phenotypic profile PCs also analysed to determine if there an association clinical outcomes evaluate prognostic value markers. Our results revealed...
<b><i>Introduction:</i></b> Critically ill patients are exposed to a high risk of developing thromboembolism. Moreover, standard prophylaxis with subcutaneous (SC) heparin is less efficient in requiring vasopressors. The aim comparison pharmacokinetics between SC and intravenous (IV) applied nadroparin. <b><i>Methods:</i></b> Thirty-eight ventilated ICU vasopressor support were randomized into single dose nadroparin 3,800 IU (0.4 mL)...