A5012250673- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Pancreatic function and diabetes
- Genetics and Neurodevelopmental Disorders
- Folate and B Vitamins Research
- Diabetes and associated disorders
- Autoimmune and Inflammatory Disorders Research
- Liver Disease and Transplantation
- Economic and Financial Impacts of Cancer
- Autism Spectrum Disorder Research
- MRI in cancer diagnosis
- Biochemical and Molecular Research
- Health Systems, Economic Evaluations, Quality of Life
- Acute Lymphoblastic Leukemia research
- Neurological diseases and metabolism
- Genetic Associations and Epidemiology
- Metabolism, Diabetes, and Cancer
- Neurogenetic and Muscular Disorders Research
- RNA modifications and cancer
- HIV/AIDS drug development and treatment
- Congenital Heart Disease Studies
- Peroxisome Proliferator-Activated Receptors
- Multiple and Secondary Primary Cancers
- Child Nutrition and Feeding Issues
Duquesne University
2018-2023
Texas A&M University
2021-2023
Barrow Neurological Institute
2020-2023
Phoenix Children's Hospital
2020-2023
University of Arizona
2020-2023
The University of Texas MD Anderson Cancer Center
2021-2022
Tennessee State University
2019
Arkansas Children's Hospital
2010-2011
University of Arkansas for Medical Sciences
2004-2011
The Centers
2010
Pantothenate kinase (PanK) is the key regulatory enzyme in CoA biosynthetic pathway bacteria and thought to play a similar role mammalian cells. We examined this hypothesis by identifying characterizing two murine cDNAs that encoded PanK. The were predicted arise from alternate splicing of same gene yield different mRNAs encode isoforms (mPanK1alpha mPanK1beta) with distinct amino termini. protein sequence mPanK1 was not related bacterial PanK but exhibited significant similarity Aspergillus...
Abstract Chediak‐Higashi syndrome (CHS) is a rare autosomal recessive disorder characterized by severe immunologic defects, reduced pigmentation, bleeding tendency, and progressive neurological dysfunction. Most patients present in early childhood die unless treated bone marrow transplantation. About 10–15% of exhibit much milder clinical phenotype survive to adulthood, but develop often fatal Very an intermediate adolescent CHS phenotype, presenting with infections childhood, course...
Abstract Background Developmental regression (DR) occurs in about one‐third of children with Autism Spectrum Disorder (ASD) yet it is poorly understood. Current evidence suggests that mitochondrial function not normal many ASD. However, the relationship between and DR has been well‐studied Methods This cross‐sectional study 32 children, 2 to 8 years old ASD, ( n = 11) without 12) DR, non‐ASD controls 9) compared respiration mtDNA damage copy number groups their relation standardized measures...
Ethanolamine kinase (EKI) is the first committed step in phosphatidylethanolamine (PtdEtn) biosynthesis via CDP-ethanolamine pathway. We identify a human cDNA encoding an ethanolamine-specific EKI1 and structure of the<i>EKI1</i> gene located on chromosome 12. <i>EKI1</i>overexpression COS-7 cells results 170-fold increase ethanolamine kinase-specific activity accelerates rate [<sup>3</sup>H]ethanolamine incorporation into PtdEtn as function concentration culture medium. Acceleration pathway...
Background. Ethnic differences in chronic kidney disease (CKD) progression are not well characterized but of interest across and within countries. Methods. We followed up a large CKD cohort patients three different ethnic origins [Caucasian, Oriental Asian (OA) South (SA)] from time nephrology referral universal health care system. Key outcomes were to death and/or renal replacement therapy (RRT) rate decline estimated GFR (eGFR). The effects known predictors (blood pressure, proteinuria,...
The majority of congenital heart defects (CHDs) are thought to result from the interaction between multiple genetic, epigenetic, environmental, and lifestyle factors. Epigenetic mechanisms attractive targets in study complex diseases because they may be altered by environmental factors dietary interventions. We conducted a population based, case-control genome-wide maternal DNA methylation determine if alterations gene-specific were associated with CHDs. Using Illumina Infinium Human...
To investigate whether women with congenital heart defect (CHD)-affected pregnancies were more likely to have functional single-nucleotide polymorphisms in genes encoding enzymes folate-dependent pathways.A population-based case-control study of 572 CHD-affected and 363 the control group was conducted. DNA samples genotyped for three folate pathway enzymes. Maternal lifestyle factor information obtained using standardized interviews.Women case 1.5 times be obese (body mass index 30 or...
Autism spectrum disorder (ASD) is a neurodevelopmental that associated with unique changes in mitochondrial metabolism, including elevated respiration rates and morphological alterations. We examined electron transport chain (ETC) complex activity fibroblasts derived from 18 children ASD as well morphology measurements the participants four typically developing controls. In participants, symptoms severity was measured by Social Responsiveness Scale Aberrant Behavior Checklist. Mixed-model...
Abstract Assessing Medicare payment trends for cervical cancer care is important to mitigate the financial impact on Medicare. This multiyear cross-sectional study included 65 years and older patients in SEER registries diagnosed between 2010-2019 who had continuous Part A B coverage at least 6 months prior diagnosis within first year of were not enrolled any Health Maintenance Organization this duration. The main outcomes total service-specific mean monthly payments a diagnosis. 2147...
Chediak-Higashi syndrome (CHS) is a rare, usually fatal, autosomal recessive disorder characterized by severe immunologic defects, reduced pigmentation, progressive neurologic dysfunction and bleeding diathesis. The hallmark of CHS giant organelles granules in many different cell types, most likely the result defective trafficking specific organellar granular proteins necessary for normal genesis, structure or function these cytoplasmic components. CHS1 gene has recently been identified...
Pantothenate kinase (PanK) is thought to catalyze the first rate-limiting step in CoA biosynthesis. The full-length cDNA encoding human PanK1α protein was isolated, and complete PANK1 gene structure determined. Bezafibrate (BF), a hypolipidemic drug peroxisome proliferator activator receptor-α (PPARα) agonist, specifically increased hPANK1α mRNA expression hepatoblastoma (HepG2) cells as function of time dose drug, compared with hPANK1β, hPANK2, hPANK3, which did not significantly increase....
There are two mammalian genes that encode isoforms of CTP:phosphocholine cytidylyltransferase (CCT), a key rate-controlling step in membrane phospholipid biogenesis. Quantitative determination the CCT transcripts reveals CCTα is ubiquitously expressed and found at highest levels testis lung, with lower liver ovary. CCTβ2 very minor isoform most tissues but significantly brain, gonads. CCTβ3 third recently discovered mice same as CCTβ2, its level testes. We investigated role(s) by generating...
The gene encoding the transcription factor upstream stimulatory (USF)1 influences susceptibility to familial combined hyperlipidemia (FCHL) and triglyceride levels. Phenotypic overlap between FCHL type 2 diabetes makes USF1 a compelling positional candidate for widely replicated linkage signal on chromosome 1q. We typed 22 variants in F11R/USF1 region (1 per 3 kb), including those previously implicated FCHL-susceptibility (or proxies thereof) 3,726 samples preferentially enriched 1q linkage....
Novel fluorinated 2-amino-4-oxo-6-substituted pyrrolo[2,3-d]pyrimidine analogues 7–12 were synthesized and tested for selective cellular uptake by folate receptors (FRs) α β or the proton-coupled transporter (PCFT) antitumor efficacy. Compounds 8, 9, 11, 12 showed increased in vitro antiproliferative activities (∼11-fold) over nonfluorinated 2, 3, 5, 6 toward engineered Chinese hamster ovary HeLa cells expressing FRs PCFT. also inhibited proliferation of IGROV1 A2780 epithelial ovarian...
Conotruncal heart defects (CTDs) are malformations that affect the cardiac outflow tract and typically cause significant morbidity mortality. Evidence from epidemiological studies suggests maternal folate intake is associated with a reduced risk of defects, including CTD. However, it unclear if folate-related gene variants have an interactive effect on CTDs. In this study, we performed targeted sequencing genes DNA 436 case families CTDs who enrolled in National Birth Defects Prevention...
Introduction: Heated Tobacco Products (HTP) have the potential to attain high uptake in US. The current study estimated prevalence of awareness, use and factors associated with awareness HTP among US adults. Methods: This included 3201 respondents from Health Information National Trends Survey (HINTS) 5 Cycle 4 (2020). ever adults were estimated. Multivariable logistic regression was conducted identify HTP. Results: About 15% adult population aware HTP, while 2.2% had used Age between 35 49...
Cirrhosis is the most important risk factor of hepatocellular carcinoma (HCC), and patients with cirrhosis are recommended to receive semiannual surveillance for early HCC detection. However, often asymptomatic can go undiagnosed years, leading underuse in clinical practice. We characterized frequency associated factors unrecognized a national sample from United States. aged 68 years older, diagnosed during 2011 2015 were included SEERMedicare Linked Database. If was within 6 months...