A5021856529- Sarcoma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- Lung Cancer Research Studies
- Vascular Tumors and Angiosarcomas
- Cancer-related Molecular Pathways
- Metastasis and carcinoma case studies
- Bone Tumor Diagnosis and Treatments
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Genetic factors in colorectal cancer
- Cardiac tumors and thrombi
- Cancer Research and Treatments
- Cancer Diagnosis and Treatment
- Cancer Cells and Metastasis
- Sulfur-Based Synthesis Techniques
- Synthesis and biological activity
- Gastrointestinal Tumor Research and Treatment
- Synthesis and Characterization of Heterocyclic Compounds
- Colorectal and Anal Carcinomas
- Musculoskeletal synovial abnormalities and treatments
- Sleep and Wakefulness Research
- Quinazolinone synthesis and applications
- Phytochemicals and Antioxidant Activities
- Asthma and respiratory diseases
- Psoriasis: Treatment and Pathogenesis
Rohto Pharmaceutical (Japan)
2021-2023
Tottori University
2003-2023
National Cancer Research Institute
2023
Aichi Cancer Center
2018
Kindai University
2010-2011
Vehicle Technologies Office
2008
Osaka Medical Center for Cancer and Cardiovascular Diseases
2001-2004
Osaka National Hospital
2001
Osaka Hospital
2001
Massachusetts Institute of Technology
2001
Transgenic mice deficient for the p53 gene were reported to frequently develop angiosarcoma (AS), suggesting that alterations in are associated with tumorigenesis of AS. However, little is known about genetic changes, including alterations, human AS because its rarity. We analyzed mutations on paraffin-embedded specimens from 33 patients by polymerase chain reaction–single-strand conformation polymorphism (PCR-SSCP) followed direct sequencing. Age ranged 18 91 (median 70) years, a male...
From 1997 to 2003, 40 patients (all <40 years of age) with non-metastatic osteosarcoma the extremities were treated OOS-D and definitive surgery. Two cycles doxorubicin 90 mg/m2 plus cisplatin 120 ifosfamide 15 g/m2 given as neoadjuvant chemotherapy, two doxorubicin/cisplatin ifosfamide, high-dose methotrexate (10–12 g/m2) post-operatively. All underwent limb salvage surgeries, 66% showed good response chemotherapy. With a median follow-up period 117 months, 31 evaluable continuously...
Information on prognostic factors is essential to establish appropriate therapeutic modalities for soft tissue sarcoma (STS). To evaluate the biological nature and of STS, p53 bcl-2 expression was immuno-histochemically studied paraffin-embedded sections from 70 patients with STS in extremities trunk. In addition, degree apoptosis examined by situ end-labeling. Histologic diagnoses these cases were malignant fibrous histiocytoma 29 cases, liposarcoma 11, synovial leiomyosarcoma 5, neurogenic...
The purpose of this study was to investigate whether patients with COPD are under oxidative stress and elucidate the relationship between level antioxidant vitamins.Nineteen male 13 age- matched control subjects were studied. Urinary 8-hydroxydeoxyguanosine (8-OHdG) concentrations determined using an enzyme-linked immunosorbent assay kit corrected for creatinine concentrations. Serum levels vitamin C, alpha-tocopherol, beta-carotene by high performance liquid chromatography.The median...
Seventy-two small-sized (<or=2 cm in diameter) lung adenocarcinomas consisting of 15 noninvasive and 57 invasive tumors were subjected to whole genome allelic imbalance (AI) scanning mutational analysis the EGFR, KRAS, TP53 genes elucidate genetic pathways early-stage adenocarcinomas. The chromosome 13q13 region showed most frequent AI (58%) was affected at similar frequencies between (53% 60%, respectively), as EGFR KRAS mutations were. number regions well frequency significantly higher...
The association of Epstein-Barr virus (EBV) and Hodgkin's disease (HD) has been suggested by serologic, epidemiologic, molecular biologic studies. high level EBV with HD in the developing countries was discussed relation to incidence these areas. Japanese shows a distinct peak older adults. In contrast, Western bimodal pattern, first young adulthood second patients. present study, Japan investigated, results were compared those reported from industrialized countries.Fifty-seven patients...
Background. In Japan, the relative risk for renal cell carcinoma (RCC) in transplants was about 80-fold higher than that general population. Depressed immune surveillance due to use of immunosuppressive agents considered cause cancer. Before transplantation, a vast majority patients received hemodialysis, known causative factor acquired cystic disease kidney (ACDK). Because ACDK is also predispose RCC, at least two factors cancer accumulate transplants. Methods. our study,...
Abstract Paraneoplastic syndromes (PNSs) associated with mesenchymal tumors are uncommon. Previous reports sporadically described inflammatory PNSs elevated serum C‐reactive protein (CRP) levels and leukocytosis in patients malignant fibrous histiocytoma (MFH) of soft tissue; however, the relationship between other subtypes MFH PNS has not been extensively investigated. Forty‐six primary tissues who underwent radical surgery were retrospectively analyzed. These divided into 2 groups...
Abstract Octanoyl, dodecanoyl and hexadecanoyl ascorbates were synthesized by the condensation of ascorbic acid corresponding fatty acids in acetone using an immobilized lipase from Candida antarctica . The oxidation process methyl linoleate (ML) as oil droplet ML/W emulsion with or acyl ascorbate was measured at 40 °C, their antioxidative properties examined. Hydrophilic proxidant, AAPH, lipophilic AMVN, added to water phase investigate properties, kinetic parameters for expressed Weibull...
Abstract Psoriasis is a persistent inflammatory skin disease thought to arise as result of the infiltration cells and activation keratinocytes. Recent advances in basic research clinical experience revealed that interleukin (IL)‐23/IL‐17 axis has been identified major immune pathway psoriasis. However, it remains unclear how keratinocyte factors contribute pathology Keratinocyte proline‐rich protein (KPRP) insoluble protein, which present epidermis likely be involved barrier function. Here,...
The retinoblastoma gene product (RB protein) plays a key role in the progression of cell cycle from G1 to S phase normal and neoplastic cells. activity RB is regulated by phosphorylation dephosphorylation with cell-cycle-dependent protein kinases. We investigated effect kinase inhibitors, staurosporine 7-hydroxy-staurosporine (UCN-01), on expression N417 small lung cancer cells (absent RB), H209 (mutant Ma-31 non-small (wild-type using immunologic blotting. Staurosporine UCN-01 each...
Bofutsushosan (BTS; fangfengtongshengsan in Chinese) is a formula traditional Japanese Kampo and Chinese medicine comprising 18 crude drugs used to treat obesity metabolic syndrome. In our previous study, BTS boiling water extract inhibited the uptake of fructose absorbed via glucose transporter 5 into cultured cells. this inhibitory effect on absorption from intestine was investigated vivo. The orally administered rats at doses equivalent 25-fold daily dose for humans. One minute after...
To clarify metastatic patterns, and histologic radiologic features in skeletal metastases from gastric cancer, 48 patients were retrospectively analyzed. The mean age of the at time diagnosis cancer was 59 years. In 31 with a history radical surgery, interval between surgery metastasis 14 months. duration death 60 days. Scintigraphic assessment showed that solitary osseous lesions found four patients, whereas remaining 44 had multiple lesions. 28 bone-only absence visceral metastases, higher...
Epidemiologic studies have revealed an increased risk for development of transitional cell carcinoma (TCC) among dye workers/painters occupationally exposed to aromatic amines such as benzidine, beta-naphthylamine, orthotoluidine, and aniline. In the present study, p53 gene mutations in 26 patients with bladder lesions were examined by single-strand conformation polymorphism analysis PCR-amplified DNA segments, followed direct sequencing. All male, age at admission ranged from 43 75 (median...