A5067591681- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Lung Cancer Research Studies
- Cancer Mechanisms and Therapy
- Esophageal Cancer Research and Treatment
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
Shanxi Medical University
2022-2025
Shanxi Provincial Cancer Hospital
2021
ABSTRACT Objective To explore the clinical value of molecular residual disease detection based on circulating tumor DNA (ctDNA‐MRD) in perioperative period esophageal squamous cell carcinoma (ESCC) and to analyze escape mechanisms MRD‐positive cases. Methods A total 35 ESCC patients were prospectively enrolled. Preoperative postoperative (1 month after surgery) blood surgical tissue samples analyzed. ctDNA variants tracked plasma assess ctDNA‐MRD, whole‐transcriptome sequencing was performed...
Circular RNAs (circRNAs) participate in the occurrence and progression of many cancers. CircRNA ataxin 7 (circATXN7) (circBase ID: hsa_circ_0066436) plays a promoting influence on gastric cancer progression. However, biological role circATXN7 non-small cell lung (NSCLC) is indistinct.Levels circATXN7, microRNA (miR)-7-5p, profilin 2 (PFN2) mRNA were detected using quantitative real-time polymerase chain reaction (RT-qPCR). Proliferation, apoptosis, metastasis, invasion analyzed counting...
Cisplatin (DDP)-induced chemoresistance is an important reason for the failure of non-small cell lung cancer (NSCLC) treatment. Circular RNAs (circRNAs) participate in diverse cancers. However, function hsa_circ_0017639 (circ_0017639) DDP resistance NSCLC unclear. Forty-one samples (21 DDP-resistant and 20 DDP-sensitive samples) were utilized research. The relative expression levels some genes determined by real-time quantitative polymerase chain reaction (RT-qPCR)....
Circular RNAs (circRNAs) are reported as competing endogenous (ceRNAs) and play key roles in non-small-cell lung cancer (NSCLC) progression. Thus, this study was aimed at clarifying underlying molecular mechanisms of circHUWE1 NSCLC.The quantitative real-time polymerase chain reaction (RT-qPCR) western blot analyses were used for examining circHUWE1, microRNA-34a-5p (miR-34a-5p), tumor necrosis factor alpha-induced protein 8 (TNFAIP8). IC50 cisplatin (DDP) A549/DDP H1299/DDP cells cell...
Our study assessed the effect of miR-21 mediating Nerve Cell Adhesion Molecule (NCAM) and Glial Cell-line Derived Neurotrophic Factor (GDNF) on proliferation apoptosis lung cancer cells. Lung cell-line H460 cells were grouped as group (LC group) (normal cultivation); Mimic (SI which was transfected with 120 nmol/L mimics liposomes; Inhibitor (IN (transfection inhibitor liposomes) followed by analysis cell Hoechst 33258 staining, GDNF level immunohistochemistry, qRT-PCR, CCK-8 NCAM western...