A5102820410- Pain Mechanisms and Treatments
- Anesthesia and Pain Management
- Anesthesia and Sedative Agents
- Nerve injury and regeneration
- Veterinary Pharmacology and Anesthesia
- Dental Anxiety and Anesthesia Techniques
- Pediatric Pain Management Techniques
- Neuroscience and Neuropharmacology Research
- Traditional Chinese Medicine Studies
- Endometrial and Cervical Cancer Treatments
- Reproductive System and Pregnancy
- Hormonal and reproductive studies
- Intramuscular injections and effects
- Treatment of Major Depression
- Wnt/β-catenin signaling in development and cancer
- Anesthesia and Neurotoxicity Research
- Pain Management and Treatment
- Colorectal Cancer Screening and Detection
- Cancer-related molecular mechanisms research
- Plant-based Medicinal Research
- Toxin Mechanisms and Immunotoxins
- Musculoskeletal pain and rehabilitation
- Microbial Inactivation Methods
- Adipokines, Inflammation, and Metabolic Diseases
- Spine and Intervertebral Disc Pathology
China Medical University
2017-2025
China Medical University Hospital
2017-2025
National Yang Ming Chiao Tung University
2020
Kaohsiung Chang Gung Memorial Hospital
2002-2014
Chang Gung University
2003-2014
Klinik für Schlafmedizin
2003
University Hospital Münster
2003
Augenstern
2003
Memorial Hospital of South Bend
2002-2003
Chang Gung Memorial Hospital
2003
<b>Background and study aims</b>: The best anesthesia methods for analgesia sedation during gastrointestinal endoscopy are still debated. aim of this was to compare the recovery time, clinical presentations, satisfaction between target-controlled infusion (TCI) manually controlled (MCI) in same-day bidirectional (esophagogastroduodenoscopy followed by colonoscopy). <b>Patients methods:</b> A total 220 patients with American Society Anesthesiology physical status 1 or 2 were enrolled...
Although norepinephrine is known to enhance the antinociceptive effect of local anesthetic lidocaine, effects two precursors norepinephrine, tyramine and octopamine, on potency lidocaine are not known. We aimed investigate cutaneous interactions mechanism action their respective co-injections with in comparison norepinephrine. Cutaneous nociceptive blockade rats was quantified by blockage trunci muscle reflexes induced needle pinpricks. Isobolographic analysis employed estimate between drugs...
Background: Pain on injection is still a major problem with propofol. We performed this study to compare different doses of intravenous (i.v.) ketorolac and without venous occlusion its effect the incidence severity pain after propofol injection. Methods: conducted prospective, randomized double‐blind 180 patients (20–60 years age.) scheduled undergo elective surgery. Six groups were generated: group A received normal saline (NS) 2 ml i.v.; B, C, D 10 mg in NS (VO) subsequent at either 30,...
Neuropathic pain due to peripheral nerve injury may be associated with abnormal central activity. Glial cell-line-derived neurotrophic factor (GDNF) can help attenuate neuropathic in different animal models of injury. However, whether GDNF ameliorate the spinal cord dorsal horn (SCDH) constriction-induced remains unknown. We investigated therapeutic effects adenoviral-mediated on behaviors, microglial activation, pro-inflammatory cytokine expression and programmed cell death a chronic...
Autophagy, an important cellular homeostatic mechanism regulates cell survival under stress and protects against acute kidney injury. However, the role of long noncoding RNA (lncRNA) in autophagy regulation renal tubular cells (HK-2) is unclear. The study was aimed to understand importance lncRNA hypoxia-induced HK-2 cells. LncRNA eosinophil granule ontogeny transcript (EGOT) identified as autophagy-associated hypoxia. EGOT expression significantly downregulated during autophagy. Gain-...
Objectives: Observational studies suggested that patients with type 2 diabetes mellitus (T2DM) presented a higher risk of developing colorectal cancer (CRC). The current study aims to create deep neural network (DNN) predict the onset CRC for T2DM. Methods: We employed national health insurance database Taiwan predictive models detecting an increased subsequent development in T2DM Taiwan. identified total 1,349,640 between 2000 and 2012 newly diagnosed All available possible factors were...
Injury to, or dysfunction of, the nervous system can lead to spontaneous pain, hyperalgesia, and/or allodynia. It is believed that number and activity of GABAergic neurons gradually decreases over dorsal horn. Glutamic acid decarboxylase (GAD) immunocompetence has been demonstrated on spinal progenitor cells (SPCs) cultivated in vitro. The intrathecal implantation these may provide a means alleviating neuropathic pain. Chronic constriction injury (CCI) sciatic nerve was used induce chronic...
Background: It is well known that long‐term morphine administration results in tolerance, which limits the clinical use of this drug pain management. Methods: Male Wistar rats were randomly assigned to receive one four different infusions: [15 μg/h, intrathecal (i.t.)], saline, MK‐801 (5 i.t.) plus (15 i.t.), or alone. Results: Morphine infusion induced a maximal antinociceptive effect on day 1 and tolerance 3, anti‐receptive was observed 5. Co‐infusing with attenuated morphine's tolerance....
This study observed the cutaneous analgesic effect of adrenergic agonists when combined with lidocaine. We aimed at usefulness four and epinephrine as analgesics or tools to prolong local anesthetics using a model trunci muscle reflex (pinprick pain) in rats. showed that subcutaneous epinephrine, well anesthetic bupivacaine lidocaine, developed concentration-dependent analgesia. The rank order efficacy different compounds (ED50 ; median effective dose) was [0.013 (0.012-0.014) μmol] >...
BACKGROUND: The objective of the experiment was to assess antinociceptive effect dibucaine, bupivacaine, and epinephrine. To mechanism action interaction between dibucaine epinephrine, phentolamine, a nonselective α-adrenergic antagonist, added mixture. METHODS: We assessed sensory blockade with these drugs by injecting 0.6 mL drug-in-saline in dorsal thoracolumbar area rats; pinprick “wheal” formed injectate targeted for stimulation elicit cutaneous trunci muscle reflex. block compared that...
Opioids remain the most efficacious pharmacological agents for various clinical pain syndromes. Recently, engineered cells capable of secreting opioidergic peptides have been applied to relieve in animal models. In vivo gene delivery by viruses encoding endogenous opioids has also used with success. this study, we attempted non-viral intrathecal electroporation induce analgesia. Thirty Sprague-Dawley rats were six each five groups. Rats treated as follows: vehicle without (group A), B), 100...
To investigate the association between adiponectin (ADIPOQ) genotypes and colorectal cancer (CRC) risk among Taiwanese.Polymerase chain reaction-restriction fragment length polymorphism was adopted to identify ADIPOQ rs266729, rs2241766 rs1501299 362 CRC patients healthy controls.ADIPOQ rs266729 GG genotype (p=0.0075) G allele (p=0.0061) are associated with a significantly increased risk. There is no differential distribution of genotypes. As for gene-lifestyle interaction, there obvious...
Flap endonuclease 1 (FEN1), a protein with multiple functions in genome stability maintenance, is important cancer prevention. The two functional germline variants of FEN1, rs174538 and rs4246215, regarding susceptibility have been reported lung, breast, liver, esophageal, gastric, colorectal cancer, glioma leukemia, but not endometriosis. In this study, we firstly aimed at evaluating the contribution FEN1 genotypes to endometriosis risk representative Taiwan population.In total, 153...
The objective of this experiment was to investigate spinal anaesthetic effects pramoxine and its comparison with bupivacaine, a long-lasting local anaesthetic.After intrathecal injection, three neurobehavioural assessments, which consisted nociceptive, proprioceptive motor block, were constructed in rats. bupivacaine (four doses each drug) dose-related manner conducted obtain the ED50 (50% effective dose). Pramoxine potency duration at provoking block compared those bupivacaine.We manifested...
The purpose of the experiment was to estimate whether intrathecal antimalarial drugs could provoke spinal block, and their comparison with lidocaine.
The purpose of the experiment was to study effect L-NAME (N(Omega)-nitro-L-arginine methyl ester) and its cotreatment with lidocaine on spinal block infiltrative cutaneous analgesia.The quality analgesia examined by trunci muscle reflexes following needle stimuli in rat. Spinal anaesthetic potency assessed measuring three neurobehavioral examinations nociceptive, proprioceptive motor function intrathecal injection rat.L-NAME (0.6, 6 60 nmol) when (ED50) produced dose-related analgesia....
This present study was undertaken to determine whether beta-blockers produce the cutaneous analgesic effect, comparing them with long-acting local anesthetic bupivacaine.Using a rat model of infiltrative analgesia, effect 5 (oxprenolol, carteolol, butaxamine, metoprolol, and acebutolol) bupivacaine compared eventually combined epinephrine.Among beta-blockers, oxprenolol exhibited most potent longest duration analgesia. In dose-response studies, rank order efficacy (ED50 [50% effective dose])...
Background This study examined the cutaneous analgesic effects of lidocaine co-injected with guanfacine and its comparison dexmedetomidine.