Tim Causon

ORCID: 0000-0003-1373-7493
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About
Contact & Profiles
Research Areas
  • Mass Spectrometry Techniques and Applications
  • Analytical Chemistry and Chromatography
  • Metabolomics and Mass Spectrometry Studies
  • Microfluidic and Capillary Electrophoresis Applications
  • Isotope Analysis in Ecology
  • Pesticide Residue Analysis and Safety
  • Microbial Metabolic Engineering and Bioproduction
  • Advanced Chemical Sensor Technologies
  • Advanced Proteomics Techniques and Applications
  • Innovative Microfluidic and Catalytic Techniques Innovation
  • Protein purification and stability
  • Fermentation and Sensory Analysis
  • Plant Micronutrient Interactions and Effects
  • Extraction and Separation Processes
  • Plant biochemistry and biosynthesis
  • Analytical chemistry methods development
  • Phytochemicals and Antioxidant Activities
  • Marine and coastal ecosystems
  • Chromatography in Natural Products
  • Ion-surface interactions and analysis
  • Hormonal and reproductive studies
  • Membrane Separation and Gas Transport
  • Membrane Separation Technologies
  • Plant Stress Responses and Tolerance
  • Biofuel production and bioconversion

BOKU University
2016-2025

University of Vienna
2024-2025

Czech Academy of Sciences, Institute of Analytical Chemistry
2020-2024

Austrian Centre of Industrial Biotechnology (Austria)
2016-2017

Johannes Kepler University of Linz
2012-2014

University of Tasmania
2010-2012

Vrije Universiteit Brussel
2011

Australian Centre for Research on Separation Science
2008

Collision cross section (CCS) measurements resulting from ion mobility–mass spectrometry (IM-MS) experiments provide a promising orthogonal dimension of structural information in MS-based analytical separations. As with any molecular identifier, interlaboratory standardization must precede broad range integration into workflows. In this study, we present reference drift tube mobility mass spectrometer (DTIM-MS) where improvements on the measurement accuracy experimental parameters...

10.1021/acs.analchem.7b01729 article EN Analytical Chemistry 2017-08-01

Measuring the exposome remains a challenge due to range and number of anthropogenic molecules that are encountered in our daily lives, as well complex systemic responses these exposures. One option for improving coverage, dynamic throughput measurements is incorporate ion mobility spectrometry (IMS) into current MS-based analytical methods. The implementation IMS exposomics studies will lead more frequent observations previously undetected chemicals metabolites. LC-IMS-MS provide increased...

10.4155/bio-2016-0244 article EN cc-by-nc-nd Bioanalysis 2016-12-06

Cell line-specific, genome-scale metabolic models enable rigorous and systematic in silico investigation of cellular metabolism. Such have recently become available for Chinese hamster ovary (CHO) cells. However, a key ingredient, namely an experimentally validated biomass function that summarizes the composition, was so far missing. Here, we close this gap by providing extensive experimental data on composition 13 parental producer CHO cell lines under various conditions. We report total...

10.1016/j.ymben.2020.06.002 article EN cc-by Metabolic Engineering 2020-06-30

Within recent years there has been an increase in research focused on the design and application of organic polymer monoliths all areas separation science. This is largely driven by theoretical practical benefits that these materials should be able to provide, particularly terms improved biocompatibility high permeability. review summarises new developments this field with a focus approaches synthesis polymeric monolithic for analytical includes use alternative synthetic methodologies such...

10.1039/c2an35804b article EN The Analyst 2012-01-01

The major benefits of integrating ion mobility (IM) into LC-MS methods for small molecules are the additional separation dimension and especially use IM-derived collision cross sections (CCS) as an ion-specific identification parameter. Several large CCS databases now available, but outliers in experimental interplatform IM-MS comparisons identified a critical issue routine identity confirmation. We postulate that different external calibration strategies applied traveling wave (TWIM-MS)...

10.1007/s00216-022-04263-5 article EN cc-by Analytical and Bioanalytical Chemistry 2022-08-12

Steroids play key roles in various biological processes and are characterized by many isomeric variants, which makes their unambiguous identification challenging. Ion mobility-mass spectrometry (IM-MS) has been proposed as a suitable platform for this application, particularly using collision cross section (CCS) databases obtained from different commercial IM-MS instruments. CCS is seen an ideal additional parameter steroids long-term repeatability interlaboratory reproducibility of...

10.1021/jasms.2c00196 article EN cc-by Journal of the American Society for Mass Spectrometry 2022-09-01

3-Pyridylcarbinol ester derivatization introduces a universal probe for cryogenic gas-phase infrared spectroscopy of fatty acids that enables assignment the position and configuration carbon–carbon double bonds even in presence isomers.

10.1039/d2sc06487a article EN cc-by-nc Chemical Science 2023-01-01

A nutritious and healthy diet relies on consuming cereals with sufficient micronutrient content, making the production of nutrient-rich crops a crucial agricultural goal. Identifying key strategies for plant acquisition is essential, this especially critical regions where calcareous or nutrient-deficient soils limit bioavailability.Plants can enhance nutrient uptake by increasing exploration soil volume through root growth releasing exudates that facilitate mining. Barley, along other...

10.5194/egusphere-egu25-19741 preprint EN 2025-03-15

Micronutrient (MN) deficiencies, particularly of iron (Fe), zinc (Zn), and copper (Cu), are major constraints to crop productivity in arid semi-arid regions characterized by high-pH calcareous soils. Effective strategies for acquiring MN essential ensure high yields on nutrient-depleted soils produce MN-rich crops. In the case iron, grass species (Poaceae) increase Fe phytoavailability releasing root exudates called phytosiderophores (PS), which have capability chelate mobilize from soil,...

10.5194/egusphere-egu25-10032 preprint EN 2025-03-14

Concerning polymeric monolithic materials utilized in separation science, the structural and mechanical characteristics from nanoscopic to macroscopic scale remain of great interest. Suitable analytical tools are urgently required understand polymer monolith's constituent structure, particularly case nanoscale properties that tend develop gel porosity contact with a mobile phase ultimately affecting chromatographic performance. Herein described our first findings characterization...

10.1021/ac401303k article EN Analytical Chemistry 2013-05-28
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