A5017187452- Stress Responses and Cortisol
- Receptor Mechanisms and Signaling
- Entomopathogenic Microorganisms in Pest Control
- Neuroscience and Neuropharmacology Research
- Adipose Tissue and Metabolism
- Hormonal Regulation and Hypertension
- Insect and Arachnid Ecology and Behavior
- Circular RNAs in diseases
- Apelin-related biomedical research
- Ubiquitin and proteasome pathways
- Adrenal Hormones and Disorders
- MicroRNA in disease regulation
- Neurobiology and Insect Physiology Research
- Pharmacological Effects and Assays
- Peptidase Inhibition and Analysis
- Mycorrhizal Fungi and Plant Interactions
- RNA Research and Splicing
- Advanced Fluorescence Microscopy Techniques
- Plant and Biological Electrophysiology Studies
- Cellular transport and secretion
- Lipid Membrane Structure and Behavior
- Genetics and Neurodevelopmental Disorders
Biomedicine Research Institute of Buenos Aires - CONICET - Partner Institute of the Max Planck Society
2017-2024
National University of Quilmes
2017-2024
Centro Científico Tecnológico - Tucumán
2018
Max Planck Institute for the Study of Societies
2018
Max Planck Society
2018
Circular RNAs (circRNAs) are a large class of noncoding RNAs. Despite the identification thousands circular transcripts, biological significance most them remains unexplored, partly because lack effective methods for generating loss-of-function animal models. In this study, we focused on circTulp4, an abundant circRNA derived from Tulp4 gene that is enriched in brain and synaptic compartments. By creating circTulp4-deficient mouse model, which mutated splice acceptor site responsible...
Corticotropin-releasing hormone receptor 1 (CRHR1) activates the atypical soluble adenylyl cyclase (sAC) in addition to transmembrane cyclases (tmACs). Both cAMP sources were shown be required for phosphorylation of ERK1/2 triggered by activated G protein coupled (GPCR) CRHR1 neuronal and neuroendocrine contexts. Here, we show that promotes growth arrest neurite elongation hippocampal cells (HT22-CRHR1 cells). By characterising signalling mechanisms involved neuritogenic effect, demonstrate...
Class B G protein-coupled receptors (GPCRs) are involved in a variety of human pathophysiological states. These groups membrane less studied than class A GPCRs due to the lack structural information, delayed small molecule drug discovery, and scarce fluorescence detection tools available. The corticotropin-releasing hormone type 1 receptor (CRHR1) is key player stress response whose dysregulation critically stress-related disorders: psychiatric conditions (i.e. depression, anxiety,...
The aim of this work is the morphological and molecular identification five species Trichoderma associated with leaf-cutting ant nests genera Acromyrmex present in Argentina. identified were T. lentiforme, inhamatum, virens, koningiopsis aff. neotropicale resulting first record lentiforme inhamatum ants, particular lobicornis lundii for one A. second one. Moreover, represents In we extend measurements conidia conidiophore contribute additional distribution country. Photographs illustrating...
Hippocampal neurons exhibit activation of both the conventional transmembrane adenylyl cyclases (tmACs) and non-canonical soluble cyclase (sAC) as sources cyclic AMP (cAMP). These two cAMP play crucial roles in mediating signaling pathways downstream CRHR1 neuronal neuroendocrine contexts. In this study, we investigate involvement molecular mechanisms triggered by CRHR2α. Here provide evidence demonstrating that UCN1 UCN3 exert a neuritogenic effect on HT22-CRHR2α cells, which is solely...
The aim of this work is the morphological and molecular identification five species Trichoderma associated with leaf-cutting ant nests genera Acromyrmex present in Argentina. identified were T. lentiforme , inhamatum virens koningiopsis aff. neotropicale resulting first record ants, particular lobicornis lundii for one A. second one. Moreover, represents In we extend measurements conidia conidiophore contribute additional distribution country. Photographs illustrating conidiophores,...
Abstract Hippocampal neurons exhibit activation of both the conventional transmembrane adenylyl cyclases (tmACs) and non-canonical soluble cyclase (sAC) as sources cyclic AMP (cAMP). These two cAMP play crucial roles in mediating signaling pathways downstream CRHR1 neuronal neuroendocrine contexts. In this study, we investigate involvement molecular mechanisms triggered by CRHR2α. Here provide evidence demonstrating that UCN1 UCN3 exert a neuritogenic effect on HT22-CRHR2α cells, which is...
ABSTRACT Corticotropin-releasing hormone receptor 1 (CRHR1) signaling initiates at the cell membrane and continues after internalization. A sustained cAMP generation ligand-activated CRHR1 endocytosis supported by soluble adenylyl cyclase (sAC) is required for G protein-independent phase of ERK1/2 phosphorylation in neuronal cells. Here, we report that Akt activated stimulation a mechanism dependent on endosomal production sAC activity. Moreover, AktS473 profile was distinct to...