A5007804681- Advanced Neuroimaging Techniques and Applications
- Neonatal and fetal brain pathology
- Advanced MRI Techniques and Applications
- Reading and Literacy Development
- Functional Brain Connectivity Studies
- Traumatic Brain Injury Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurobiology of Language and Bilingualism
- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Fetal and Pediatric Neurological Disorders
- Tactile and Sensory Interactions
- Advanced NMR Techniques and Applications
- Gastroesophageal reflux and treatments
- Neurogenetic and Muscular Disorders Research
- EEG and Brain-Computer Interfaces
- Mitochondrial Function and Pathology
- Metabolomics and Mass Spectrometry Studies
- Language Development and Disorders
- Tensor decomposition and applications
- Neurological disorders and treatments
- Prenatal Substance Exposure Effects
- Neural dynamics and brain function
- RNA modifications and cancer
- Bone and Joint Diseases
Alberta Children's Hospital
2017-2025
University of Calgary
2016-2025
Alberta Children's Hospital Research Institute
2017-2022
Allen Institute for Brain Science
2016
Seizures are often followed by sensory, cognitive or motor impairments during the postictal phase that show striking similarity to transient hypoxic/ischemic attacks. Here we seizures result in a severe hypoxic attack confined period. We measured brain oxygenation localized areas from freely-moving rodents and discovered event (pO2 < 10 mmHg) after termination of seizures. This lasted over an hour, is mediated hypoperfusion, generalizes people with epilepsy, attenuated inhibiting...
Diffusion tensor imaging (DTI) studies have provided much evidence of white and subcortical gray matter changes during late childhood early adolescence that suggest increasing myelination, axon density, and/or fiber coherence. Neurite orientation dispersion density (NODDI) can be used to further characterize development in grey regions the brain by improving specificity MRI signal compared conventional DTI. We measures from NODDI DTI examine a group 27 healthy participants aged 8-13 years....
Abstract White matter development has been well described using diffusion tensor imaging (DTI), but the microstructural processes driving remain unclear due to methodological limitations. Here, neurite orientation dispersion and density (NODDI), inhomogeneous magnetization transfer (ihMT), multicomponent driven equilibrium single‐pulse observation of T1/T2 (mcDESPOT), we describe white at level in a longitudinal cohort healthy 6–15 year olds. We evaluated age gender‐related trends fractional...
The role of white matter in reading has been established by diffusion tensor imaging (DTI), but DTI cannot identify specific microstructural features driving these relationships. Neurite orientation dispersion and density (NODDI), inhomogeneous magnetization transfer (ihMT) multicomponent driven equilibrium single-pulse observation T1/T2 (mcDESPOT) can be used to link more aspects microstructure due their sensitivity axonal packing fiber coherence (NODDI) myelin (ihMT mcDESPOT). We applied...
Abstract Introduction: Prenatal alcohol exposure (PAE) is associated with various neurological, behavioral and cognitive deficits, including reading language. Previous studies have demonstrated altered white matter in children adolescents PAE associations language performance aged 3 years older. However, little research has focused on the toddler years, despite this being a critical period for neural development. We aimed to determine between structural brain connectivity early skills...
Left temporal-parietal white matter structure is consistently associated with reading abilities in children. A small number of longitudinal studies show that development this area over time altered children impaired reading. However, it remains unclear how brain developmental patterns relate to specific skills such as fluency, which a critical part comprehension. Here, we examined trajectories dysfluent (20 and inaccurate readers, 36 accurate readers) compared non-impaired readers (n = 14)...
Abstract Sophisticated network‐based approaches such as structural connectomics may help to detect a biomarker of mild traumatic brain injury (mTBI) in children. This study compared the connectome children with mTBI or orthopedic (OI) that typically developing (TD) Children aged 8–16.99 years ( n = 83) OI 37) were recruited from emergency department and completed 3T diffusion MRI 2–20 days postinjury. TD 39) community MRI. Graph theory metrics calculated for binarized average fractional...
Abstract Developmental lateralization of brain function is imperative for behavioral specialization, yet few studies have investigated differences between hemispheres in structural connectivity patterns, especially over the course development. The present study compares or topology, across children, adolescents, and young adults. We applied a graph theory approach to quantify key topological metrics each hemisphere including efficiency information transfer regions (global efficiency),...
<title>Abstract</title> Perinatal strokes occur more commonly in the left hemisphere and often impact language areas, yet disability only occurs 20–25% of cases. Functional imaging studies investigating processing have shown that perinatal stroke may result contralesional shifts activity, but none investigated structure white matter connections such altered network conditions. Diffusion tensor neurite orientation dispersion density offer robust, microstructurally-sensitive metrics which can...
Introduction Tobacco and alcohol are the two most common substances used during pregnancy, both can disrupt neurodevelopment, resulting in cognitive behavioral deficits including language difficulties. Previous studies show that children with prenatal substance exposure exhibit microstructural alterations major white matter pathways, though few have investigated impact of on microstructure skills toddler years. Methods In this study, 93 (34 exposed to and/or tobacco) aged 23 years from...
Numerous studies have linked reading ability to white matter microstructure using diffusion tensor imaging, but recent large failed show consistency. Fiber-specific diffusion-weighted magnetic resonance imaging (dMRI) models offer enhanced precision measure specific features of structure and may be more sensitive individual differences in skills. However, fiber-specific not yet been applied examine associations between over the course acquisition. In this accelerated longitudinal study, we...
Objective Characterize the structural organization of afferent visual system in children with perinatal stroke (PS). Background PS is a leading cause lifelong disability, including cerebral palsy. Cerebral impairment (CVI) another common outcome, yet mechanisms and developmental plasticity after are not well understood. CVI can negatively impact how engage their environments, consequently affecting development, learning, therapy, play, future independence. Methods Fifty-one (22 arterial...
Motivation: High angular resolution diffusion imaging has great potential but is time-consuming so limited in pediatric clinical studies. Goal(s): To assess the utility of novel deep learning techniques for predicting non-acquired brain MRI equivalent HARDI analyses. Approach: A multilayer perceptron (MLP) and convolutional neural network (CNN) were trained to predict b=2000s/mm2 data from b=750s/mm2 data. The neurite orientation dispersion density index (NODDI) outcomes computed with...
ABSTRACT The role of white matter fibers in reading has been established by diffusion tensor imaging (DTI), but DTI cannot identify specific microstructural features driving these relationships. Neurite orientation dispersion and density (NODDI), inhomogeneous magnetization transfer (ihMT) multicomponent driven equilibrium single-pulse observation T1/T2 (mcDESPOT) can be used to link more aspects microstructure due their sensitivity axonal packing fiber coherence (NODDI) myelin (ihMT...
Abstract Background: Motion can compromise image quality and confound results, especially in pediatric research. This study evaluated qualitative quantitative approaches to motion artifacts detection correction, whether relate injury history, age, or sex children with mild traumatic brain orthopedic relative typically developing children. The concordance between ratings was also examined. Method: Children aged 8-16 years ( n =141) =73) were recruited from the emergency department completed...