A5013431940- Nuclear Receptors and Signaling
- Apelin-related biomedical research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Protein Tyrosine Phosphatases
- Immune cells in cancer
- PI3K/AKT/mTOR signaling in cancer
- Protein Kinase Regulation and GTPase Signaling
- Galectins and Cancer Biology
- Lymphatic System and Diseases
- Axon Guidance and Neuronal Signaling
- Angiogenesis and VEGF in Cancer
Inserm
2014-2022
Institut des Maladies Métaboliques et Cardiovasculaires
2019-2022
Université Toulouse III - Paul Sabatier
2019-2022
Université de Toulouse
2021-2022
Université Paris Cité
2014-2018
Centre National de la Recherche Scientifique
2014-2018
Sorbonne Paris Cité
2018
Institut Cochin
2014-2018
Hyperactive SHP2 promotes inflammation-driven insulin resistance by skewing macrophage balance in metabolic tissues and may be a target T2D.
Despite decades of effort in understanding pancreatic ductal adenocarcinoma (PDAC), there is still a lack innovative targeted therapies for this devastating disease. Herein, we report the expression apelin and its receptor, APJ, human protumoral function. Apelin APJ protein tumor tissues from patients with PDAC their spatiotemporal pattern engineered mouse models were investigated by immunohistochemistry. signaling function cells was characterized cell lines Western blot as well...
Stimulation of tyrosine kinase receptors initiates a signaling cascade that activates PI3K. Activated PI3K uses PIP2 to generate PIP3, which recruit Akt the plasma membrane through its pleckstrin homology (PH) domain, permitting activation by PDKs. controls important biological functions, including cell metabolism, proliferation and survival. The pathway is therefore an attractive target for drug discovery. However, current assays measurement PIP3 production are technically demanding not...
Abstract Kidney function is altered by age together with a declined filtration capacity of 5–10% per decade after 35 years. Renal aging shares many characteristics chronic kidney disease. Plasma levels the bioactive peptide apelin also decline and has been shown to be protective in Therefore we evaluated whether could improve aging-induced renal lesions mice. Since urine for major part composed proteins peptides originating from kidney, first studied apelin-induced changes, urinary...