A5026251485- Clostridium difficile and Clostridium perfringens research
- Gut microbiota and health
- Bacteriophages and microbial interactions
- Bacterial Identification and Susceptibility Testing
- Microbial infections and disease research
- Nosocomial Infections in ICU
- Antimicrobial Resistance in Staphylococcus
- Microscopic Colitis
- Oral microbiology and periodontitis research
- Diet and metabolism studies
- Bacterial biofilms and quorum sensing
- Healthcare cost, quality, practices
- Antibiotic Resistance in Bacteria
- Pneumonia and Respiratory Infections
- Helicobacter pylori-related gastroenterology studies
- Identification and Quantification in Food
- Rheumatoid Arthritis Research and Therapies
- Spectroscopy and Chemometric Analyses
- Oral Health Pathology and Treatment
- Listeria monocytogenes in Food Safety
- Skin Protection and Aging
- Streptococcal Infections and Treatments
- Advancements in Transdermal Drug Delivery
- Dermatology and Skin Diseases
- Inhalation and Respiratory Drug Delivery
Bioclear Earth (Netherlands)
2023
University Medical Center Groningen
2018-2022
University of Groningen
2018-2022
University of Padua
2018
Background: Virtually no studies on the dynamics of intestinal microbiota in patients admitted to intensive care unit (ICU) are published, despite increasingly recognised important role human physiology. Critical undergo treatments that renowned influence microbiota. However, and extent such changes not yet fully understood. To address this topic, we analysed before, during after planned major cardio surgery that, for first time, allowed us follow microbial critical patients. In prospective,...
Aims: We performed a randomized, placebo-controlled trial, RIBOGUT, to study the effect of 2 weeks supplementation with either 50 or 100 mg/d riboflavin on (i) Faecalibacterium prausnitzii abundance, (ii) gut microbiota composition, (iii) short-chain fatty acid (SCFA) profiles, and (iv) satiety hormones. Results: Neither dose riboflavin, analyzed separately, impacted abundance F. prausnitzii, only minor differences in SCFA concentrations were observed. However, combining results groups...
Introduction Inflammatory bowel disease (IBD) is characterized by a disturbed gut microbiota composition. Patients with IBD have both elevated mucosal and serum levels of IgG-antibodies directed against bacterial antigens, including flagellins. In this study, we aimed to determine which intestinal bacteria the humoral immune response in patients IBD. Methods Fecal samples were collected from ( n =55) age- sex-matched healthy controls =55). incubated autologous IgG-coated fractions isolated...
Both academia and dermatological cosmetic industries have acknowledged that healthy skin microbiota contribute to overall integrity well-being. This implies formulations developed for personal care (skin, scalp, hair etc) or (medical cosmetic) treatment need be compatible with conservation possibly even improvement. The various chemical biological components mixtures thereof intended direct application the should not extensively affect qualitative quantitative composition of microbiota. A...
Background: Vancomycin-resistant Enterococcus faecium (VREfm) is a successful nosocomial pathogen. The current molecular method recommended in the Netherlands for VREfm typing based on core genome Multilocus sequence (cgMLST), however, rapid emergence of specific lineages challenges distinguishing outbreak isolates solely their genome. Here, we explored if detailed characterisation mobile genetic elements (MGEs) and accessory genes could support expand sharing same background, enhancing...
Vancomycin-resistant enterococci (VRE) are successful nosocomial pathogens able to cause hospital outbreaks. In the Netherlands, core-genome MLST (cgMLST) based on short-read sequencing is often used for molecular typing. Long-read more rapid and provides useful information about genome's structural composition but lacks precision required SNP-based typing cgMLST. Here we compared prophages among 50 complete E. faecium genomes belonging different lineages explore whether a phage signature...
The relation between rheumatoid arthritis (RA) and periodontitis (PD) has been investigated ever since the discovery of citrullinating enzyme peptidyl arginine deaminase presents in oral bacterium Porphyromonas gingivalis. Recently, we demonstrated presence RA autoantibodies, especially IgA anti-citrullinated protein antibody (ACPA), gingival crevicular fluid (GCF) Indonesian patients with without or PD which might indicate local formation antibodies periodontium.The purpose this study was...
A particular role for Porphyromonas gingivalis (Pg) and Aggregatibacter actinomycetemcomitans (Aa) has been suggested in periodontitis rheumatoid arthritis (RA), as these bacteria could initiate the formation of factor (RF) anticitrullinated protein autoantibodies (ACPA). We assessed whether serum antibodies against Pg Aa RA patients non-RA controls reflect subgingival presence Aa, evaluated relationship to severity periodontal inflammation RA-specific autoantibodies. In 70 Indonesian...
Pneumonia is an infection of the lungs, where alveoli in affected area are filled with pus and fluid. Although ventilated patients at risk, not all develop pneumonia. This suggests that sputum environment may possess antimicrobial activities. Despite generally acknowledged importance activity protecting human lung against infections, this has been systematically assessed to date. Therefore, objective present study was measure broncho-alveolar aspirate ('sputum") samples from intensive care...
Background Although the important role of intestinal microbiota on human physiology is increasingly recognised, few studies its dynamics in patients admitted to intensive care unit (ICU) have been published. Disturbance (dysbiosis) has reported, but clinical consequences are unclear. We assessed before, during and after hospital admission planned cardio-surgical ICU. Methods In this prospective, observational, longitudinal, single centre study, we analysed at three time points scheduled for...
Abstract Background Inflammatory bowel disease (IBD) is characterized by a disturbed gut microbiota composition. Patients with IBD have elevated levels of mucosal and serum IgG-antibodies directed against bacterial antigens, including flagellins. In this study, we aimed to determine which faecal bacteria the humoral immune response in patients IBD. Methods Faecal samples were collected from (n=55) age- sex-matched healthy controls (n=55). incubated autologous IgG-coated fractions isolated...