A5086676747- Microbial Metabolites in Food Biotechnology
- Food composition and properties
- Polysaccharides and Plant Cell Walls
- Probiotics and Fermented Foods
- Glycosylation and Glycoproteins Research
- Advanced Cellulose Research Studies
- Infant Nutrition and Health
- Biofuel production and bioconversion
- Coffee research and impacts
- Carbohydrate Chemistry and Synthesis
- Infant Health and Development
- Nanoparticles: synthesis and applications
- Marine Invertebrate Physiology and Ecology
- 3D Printing in Biomedical Research
- African Botany and Ecology Studies
- Parasitic Infections and Diagnostics
- Breastfeeding Practices and Influences
- Genomics and Phylogenetic Studies
- Seaweed-derived Bioactive Compounds
- Agricultural and Food Sciences
- Gut microbiota and health
- Proteoglycans and glycosaminoglycans research
- Gene expression and cancer classification
- Advanced Biosensing Techniques and Applications
- Seed and Plant Biochemistry
University of Birmingham
2023-2025
Newcastle University
2018-2024
Akkermansia muciniphila is a human microbial symbiont residing in the mucosal layer of large intestine. Its main carbon source highly heterogeneous mucin glycoprotein, and it uses an array carbohydrate-active enzymes sulfatases to access this complex energy source. Here we describe biochemical characterization 54 glycoside hydrolases, 11 1 polysaccharide lyase from A. provide holistic understanding their carbohydrate-degrading activities. This was achieved using variety liquid chromatography...
The evolution of land flora was an epochal event in the history planet Earth. success plants, and especially flowering colonizing all but most hostile environments required multiple mechanisms adaptation. mainly polysaccharide-based cell walls which are indispensable for water transport structural support, one important adaptations to life on land. Thus, development vasculature is regarded as a seminal wall evolution, impact further refinements diversification compositions architectures...
Banana peel (BP) is the primary by-product generated during banana processing which causes numerous environmental issues. This study examines physical attributes, proximate analysis, glycoarray profiling, antioxidant abilities, and prebiotic activity of BP. The analysis demonstrated that carbohydrates constituted components BP profiling indicated contains multiple pectin hemicellulose structures. also contained phenolic compounds, including (+)-catechin gallic acid, flavonoid activities....
The development of the human gut microbiota during infancy is marked by frequent colonization Enterobacteriaceae, a bacterial family notoriously associated with various diseases. Yet, despite their prominence in absence illness, exact ecological role healthy maturation infant remains poorly explored. Here, we analyse longitudinal stool samples from healthy, term-born, breastfed neonates (n=41) at two, six, and eleven months post-delivery, as well related mothers (n=30) shotgun metagenomic...
Several bacterial species initially colonise the infant gut, but are outcompeted. Human milk oligosaccharides (HMOs) in breast create an environment for Bifidobacterium to flourish. Laursen and Roager recently showed a clear link between dominance of longum subsp. infantis gut.
Burning of food materials during cooking can increase the difficulty in removal from solid surfaces, forming residual soils. Using molecular probe-based technologies, aim this work was to elucidate composition and relative abundance glycans within a Burnt-On/Baked-On (BoBo) model soil investigate enzyme systems that may facilitate breakdown. Microarray Polymer Profiling identified xylan, arabinoxylan, mixed-linkage glucan mannan as target substrates for enzymatic cleaning BoBo residues...
Akkermansia muciniphila is a human microbial symbiont residing in the mucosal layer of large intestine. Its main carbon source highly heterogeneous mucin glycoprotein and A. uses an array Carbohydrate-active enzymes sulfatases to access this complex energy source. Here we describe biochemical characterisation fifty-four glycoside hydrolases, eleven sulfatases, one polysaccharide lyase from provide holistic understanding carbohydrate-degrading activities. The results extensive insight into...
Microarray polymer profiling (MAPP) is a robust and reproducible approach to systematically determine the composition relative abundance of glycans glycoconjugates within variety biological samples, including plant algal tissues, food materials, human, animal, microbial samples. technology underpins efficacy this method by providing miniaturized, high-throughput screening platform, allowing thousands interactions between highly specific glycan-directed molecular probes be characterized...
Pectin derived from mango peel biomass offers a noteworthy alternative to starch in food products, potentially assisting controlling hyperglycaemia by impacting digestion. Consequently, this study evaluates the potential of Mahachanok (MHMP) pectin glycaemic index (GI) reduction meat products using simulated vitro carbohydrate The physicochemical characteristics MHMP (MHMPP) were assessed both FTIR and titration techniques, with microarray polymer profiling employed analyse glycan profile....
While rapid progress has been made to characterize the bacterial and archaeal populations of rumen microbiome, insight into how they interact with keystone protozoal species remains elusive. Here, we reveal two distinct community types (RCT-A RCT-B) that are not strongly associated host phenotype nor genotype but instead linked patterns. We leveraged a series multi-omic datasets show dominant Epidinium spp. in animals RCT-B employ plethora fiber-degrading enzymes present enriched Prevotella...
Alginates are abundant linear polysaccharides produced by brown algae and some bacteria. They have multiple biological roles important medical commercial uses. comprised of D-mannuronic acid (M) L-guluronic (G) the ratios distribution patterns M G profoundly impact their physiological rheological properties. The structure/function relationships alginates been extensively studied in vitro but our understanding vivo spatiotemporal regulation alginate fine structures implications is limited....
AbstractCoffee pulp (CP), a by-product of coffee production, is an underutilized resource with significant potential value. CP contains monosaccharides that can serve as ideal carbon source for bacterial cultivation, enabling the production value-added components such medical-grade cellulose. Herein, we extracted sugar fraction from Arabica and used it supplement in growing media bacteria cellulose (BC), Komagataeibacter nataicola. The BC was then characterized tested cytotoxicity. yielded...
Food materials are typically complex and can be highly adhesive. Burning of food increase the difficulty in removal from solid surfaces, forming residual soils. Understanding responses individual components, interactions between to heat treatment is an important step towards developing more effective detersive enzymes. Here we describe application molecular probe-based technologies for analysing effects oven baking on plant-derived glycans a model Burnt-On/Baked-On soil. Microarray Polymer...