Bone mineral density (BMD) is increased in idiopathic hypoparathyroidism (IH). Parathyroid hormone (PTH) deficiency, hypocalcemic seizures, and anticonvulsants could compromise skeletal health IH.We assessed vertebral fractures (VFs) related factors IH change BMD during follow-up.VFs were by morphometry. was dual-energy X-ray absorptiometery at the lumbar spine, hip, forearm. Change a subset after 10-year follow-up.The endocrine clinic of All India Institute Medical Sciences, New Delhi,...

Basal ganglia calcification (BGC) is an interesting example of ectopic in patients with hypoparathyroidism. Its pathogenesis and reasons for predilection at basal are not clear.To assess the expression osteogenesis-related molecules caudate nucleus surface gray matter (an area spared from calcification) discuss potential relevance results context BGC idiopathic hypoparathyroidism.Caudate were obtained 14 autopsies performed accidental deaths. The mRNA bone transcription factors...

Summary Background Cholecalciferol and/or calcium supplementation might increase skeletal muscle strength and serum testosterone in young adult males. Objective We performed a randomized control trial assessing the effect of cholecalciferol/calcium on vitamin D deficient Design Two‐by‐two factorial RCT . Subject Intervention Two‐hundred twenty‐eight males were block‐randomized to (i) double‐placebo, (ii) calcium/placebo, (iii) cholecalciferol/placebo (iv) cholecalciferol/calcium. Doses for...

There is limited information on seizures in patients with idiopathic hypoparathyroidism (IH). We assessed seizure characteristics at presentation, subclinical during follow-up, and the effect of antiepileptic drug (AED) withdrawal IH patients.Seizure were 70 attending endocrine clinic. Provoked electroencephalography (EEG) was performed for 44 them. AEDs withdrawn using strict criteria, i.e. i) no past 2 years, ii) normal EEG, iii) serum total calcium ≥1.8 mmol/l, iv) feasibility to...

In view of the high burden latency tuberculosis (TB) in India, tackling latent TB right way is a menace. All TB’s infection (LTBI) are treated countries having low such as United States. However, this approach cannot be implemented like India until concrete evidence or consensus by experts on subject made. There very specific risk groups where these patients to far current evidence-based medicine concerned. Hence, need develop document was felt, through which treatment LTBI becomes...

Abstract Context There are concerns about the long-term safety of conventional therapy on renal health in patients with hypoparathyroidism. Careful audit these would help comparisons upcoming parathyroid hormone therapy. Objective We investigated nephrocalcinosis, dysfunction, and calculi, their predictors progression over follow-up primary hypoparathyroidism (PH). Design Setting An observational study at a tertiary care center was conducted. Participants Methods A total 165 PH receiving...

Patients with hypoparathyroidism are treated vitamin D and calcium. PTH is an emerging option because of its physiological action. It important to assess the efficacy shortcomings conventional therapy. We assessed safety alfacalcidol in a large cohort patients idiopathic (IH) identified subset who could be without oral Observational study at tertiary care center. 92 IH were receiving calcium maintain optimal serum total level 8.0 8.5 mg/dL during routine follow-up. suboptimal control...

Summary Background Patients with idiopathic hypoparathyroidism (IH) require variable doses of calcium and 1‐α‐(OH)D. The reasons for such variability are not clear. As autoimmune mechanisms may play a role in IH, there is possibility coexistent coeliac disease calcium/vitamin D malabsorption. Objective We assessed the prevalence antitissue transglutaminase autoantibodies (anti‐tTGAbs) IH analysed effect gluten‐free diet on calcaemic control. Method A total 171 patients 126 healthy controls...

There is reservation about accepting the notion of widespread vitamin D deficiency (VDD) in sunny countries because information base largely urban indoors, and cut-off serum 25(OH)D > 75.0 nmol/L to define sufficiency perceived as high.We assessed status subjects engaged six types outdoor jobs with freedom seek shade, when needed.Descriptive observational study.A total 573 outdoors, (hawkers, n = 144; auto-rickshaw drivers, 113; manual rickshaw pullers, 49; fuel-station attendants, 84;...

Major histocompatibility complex class I allele HLA-A*26:01 and human leukocyte antigen (HLA) supertype A01 (STA01) are increased in idiopathic hypoparathyroidism (IH). However, cell-mediated autoimmune responses directed against the calcium-sensing receptor (CaSR) have not been demonstrated. To study CaSR-specific cytotoxic T-cell peripheral blood mononuclear cells of IH patients. Twenty-four peptides CaSR (RH1 to RH24) were evaluated for their ex vivo potential stimulate PBMCs from...

Abstract Context Alfacalcidol and calcitriol are commonly used for managing hypoparathyroidism. Their relative merits have not been systematically assessed. Objective We compared the effect of alfacalcidol on phosphatemic control, hypercalciuria, associated factors in idiopathic-hypoparathyroidism (IH). Design Setting Open-label randomized controlled trial, tertiary care center. Subjects Methods IH patients with optimal calcemic control were continued same (n = 20) or switched to 25) at half...

To investigate abnormalities in bone mineral density, trabecular score and vertebral fractures male patients with alcohol use disorder to understand the impact on health.The study subjects included 134 patients. Controls were age matched healthy males. Assessments made of density (BMD), (TBS) morphometry (VFA) for fractures. Biochemical measurements serum total T4, thyroid stimulating hormone (TSH), parathyroid (PTH) 25- Hydroxyvitamin D 25(OH) D.The mean BMD at forearm, proximal forearm (or...

Some of the patients with idiopathic hypoparathyroidism (IHP) report symptoms hypocalcemia during menstruation. There is limited data on this observation. Twenty six menstruating women IHP and 26 healthy controls were questioned regarding suggestive Twelve eight asked to prospectively monitor premenstrual syndrome (PMS) if any, over two consecutive menstrual cycles. Serum ionized calcium (SiCa++), total albumin adjusted intact paratharmone (iPTH) measured at points covering menstrual,...

Abstract Context Basal-ganglia calcification (BGC) is common (70%) in patients with chronic hypoparathyroidism. Interestingly, cortical gray matter spared from calcification. The mechanism of BGC, role hyperphosphatemia, and modulation osteogenic molecules by parathyroid hormone (PTH) its pathogenesis not clear. Objective We assessed the expression a large repertoire proosteogenic or antiosteogenic effects, including neuroprogenitor cells caudate, dentate, normal autopsy tissues. effect high...

Abstract Context Hypocalcemia predisposes patients with chronic hypoparathyroidism (cHypoPT) to an increased risk of QTc prolongation and life-threatening arrhythmias. Information on clinical biochemical correlates in cHypoPT is limited. Objective To assess the significance interval its correlates. Methods This was observational cohort study at a tertiary care center. Eighty-eight nonsurgical (mean age 44.1 ± 15.4 years, 45 males) were assessed for possible including arrhythmic symptoms...

There is limited information on population-specific norms of trabecular-bone-score (TBS) and its associated factors. Here, we provide TBS in Asian-Indians relationship with serum 25-hydroxyvitamin D [25(OH)D] intact-parathyroid hormone (iPTH).

Abstract Disclosure: P.V. Namjoshi: None. S. Saha: V. Sharma: R. Narang: K. Mani: Goswami: Background: Patients with chronic hypoparathyroidism (cHypoPT) and hypocalcemia are at risk of QTc prolongation life-threatening arrhythmias. Information on clinical biochemical correlates in cHypoPT is limited. Design: Observational study cohort, tertiary-care-center.Materials methods: Eighty-eight nonsurgical patients (age 44.1±15.4 years, 45 males) were assessed for interval its possible including...

Abstract Disclosure: P.V. Namjoshi: None. S. Saha: V. Sharma: R. Goswami: Narang: K. Mani: Background: Patients with chronic hypoparathyroidism (cHypoPT) and hypocalcemia are at risk of QTc prolongation life-threatening arrhythmias. Information on clinical biochemical correlates in cHypoPT is limited. Design: Observational study cohort, tertiary-care-center.Materials methods: Eighty-eight nonsurgical patients (age 44.1±15.4 years, 45 males) were assessed for interval its possible including...

Disulfiram is widely used to treat alcohol use disorder. Alcohol per se adversely affects bone health. In the experimental study, disulfiram leads apoptosis of osteoblast and significant osteopenia in adult rats. The present study explored possibility occurrence similar osteopenic effects therapy patients with