Abstract In recent years, one of the most popular techniques in computer vision community has been deep learning technique. As a data-driven technique, model requires enormous amounts accurately labelled training data, which is often inaccessible many real-world applications. A data-space solution Data Augmentation (DA), that can artificially generate new images out original samples. Image augmentation strategies vary by dataset, as different data types might require augmentations to...

Early detection and diagnosis of oral cancer are critical for a better prognosis, but accurate automatic identification is difficult using the available technologies. Optical coherence tomography (OCT) can be used as diagnostic aid due to advantages high resolution non-invasion. We aim evaluate deep-learning-based algorithms OCT images assist clinicians in screening diagnosis. An data set was first established, including normal mucosa, precancerous lesion, squamous cell carcinoma. Then,...

In this paper, a learning-based fiber specklegram sensor for bending recognition is proposed and demonstrated. Specifically, since the curvature-induced variations of mode interference in optical fibers can be characterized by speckle patterns, Resnet18, classification model based on convolutional neural network architecture with excellent performance, used to identify state disturbed position simultaneously according patterns collected from distal end multimode fiber. The feasibility scheme...

Abstract Background Toxoplasma gondii infection affects a significant portion of the global population, leading to severe toxoplasmosis and, in immunocompromised patients, even death. During T. infection, disruption gut microbiota further exacerbates damage intestinal and brain barriers. Therefore, identifying imbalanced probiotics during restoring their equilibrium can regulate balance metabolites, thereby alleviating tissue damage. Methods Vimentin gene knockout ( vim−/− ) mice were...

Abstract Latic acid fermentation is an effective way to release the bound phenolic acids from grains dietary fiber improve biological effects in vivo. Previous analysis of whole genome sequencing and comparative proteomics has revealed that a sulfatase named LPMS Lactiplantibacillus plantarum dy‐1 ( L. dy‐1) was potential key enzyme promoting phenol barley bran fiber. In this present study, we utilized gene editing technology modify verify role releasing bond during fermentation. Results...

Background: Skull base tumors can extend into the temporal bone and occasionally even be visible through tympanic membrane (TM) if they grow middle ear cavity. The differential diagnosis of a skull mass is extensive ranges from non-tumorous lesions like cholesteatoma to benign schwannoma malignant metastatic cancer. Optical coherence tomography (OCT) noninvasive imaging technique that image tissue with high resolution in three dimensions, including structures such as TM bone. OCT angiography...

The fluorescence lifetime acts as a critical parameter for evaluating efficiency of Zero-dimensional antimony halides (ZDAH) which showed broadband emissions and large Stokes shifts optical applications. Current methods...

In this study, the different characteristics of in vitro digestion and fermentation were investigated compared with polysaccharides extracted by hot water alkali sequence from Volvariella volvacea (VWEP VAEP, respectively), as well vivo lipid-reducing effects. The results indicated that simulated saliva-gastrointestinal altered reducing sugar contents, molecular weights (from 7.398 × 104 D to 3.080 103 D, 4.110 6.080 D), chemical components, antioxidant activities VWEP respectively. However,...

Optical coherence tomography (OCT) has proven useful for detecting various oral maxillofacial abnormalities. To apply it to clinical applications including biopsy guidance and routine screening, a handheld imaging probe is indispensable. OCT probes reported were either based on bulky galvanometric mirror pair (not compact or long enough) distal-end microelectromechanical systems (MEMS) scanner (raised safety concerns), adapted from fiber-optic catheters (ill-suited cavity geometry).To...

Arabinoxylans (AXs) are non-starch polysaccharides with complex structures naturally occurring in grains (i.e., barley, corn, and others) providing many health benefits, especially as prebiotics. AXs can be classified water-extractable (WEAX) water-unextractable (WUAX) based on their solubility, properties influenced by grain sources extraction methods. A large body of evidence shows that exert an im-portant impact, including glucose lipid metabolism regulation immune system enhancement,...

Histopathological examination is still the gold standard for diagnoses of oral-maxillofacial lesions, but it invasive and time-consuming. Optical coherence tomography (OCT) provides a kind noninvasive, label-free, real-time high-resolution imaging technology. In this study, in order to assess feasibility OCT oral clinical application, fresh excised tissue specimens from 59 patients undergoing surgery were imaged detail by using benchtop swept-source system. It shown that different lesions or...

Zebrafish is an important animal model, which used to study development, pathology, and genetic research. The zebrafish skin model widely in cutaneous research, angiogenesis critical for wound healing. However, limited by the penetration depth, available optical methods are difficult describe internal structure connection of blood vessels between subcutaneous tissue. By a homemade high-resolution polarization-sensitive coherence tomography (PS-OCT) system, we imaged polarization contrast...

Distinguishing cancer from precancerous lesions is critical and challenging in oral medicine. As a noninvasive method, optical coherence tomography (OCT) has the advantages of real-time, vivo, large-depth imaging. Texture information hidden OCT images can provide an important auxiliary effect for improving diagnostic accuracy. The aim this study to explore reliable accurate OCT-based method screening diagnosis human diseases, especially cancer.Fresh ex vivo tissues including normal mucosa,...

Previous research investigating gamification and virtual laboratories has suggested that both are successful in educational outcomes, but few have looked at labs tandem. This explores the idea of contexts within one unified platform. We examine whether using is effective enhancing learners’ performance. Particularly, we employ leaderboards as a motivational mechanism for more engagement participation can result higher learning outcomes. Using sample students, our results show utilization lab...

Pathologies within the tympanic membrane (TM) and middle ear (ME) can lead to hearing loss. Imaging tools available in clinic for diagnosis management are limited visual inspection using classic otoscope. The otoscopic view is surface of TM, especially diseased ears where TM opaque. An integrated optical coherence tomography (OCT) otoscope provide images interior ME space as well an image. This enables clinicians correlate standard with OCT then use new information improve diagnostic...

Neurofibromatosis Type 2 (NF-2) is a dominantly inherited genetic disorder that results from mutations in the tumor suppressor gene, neurofibromin (NF2) gene. Here, we report generation of conditional zebrafish model neurofibromatosis established by an inducible knockout nf2a/b, homolog human NF2. Analysis nf2a and nf2b expression reveals ubiquitous early embryo, with overlapping neural crest its derivatives cranial mesenchyme. In contrast, displays lower levels. Induction nf2a/b at stages...

Depth-resolved optical attenuation coefficient is a valuable tissue parameter that complements the intensity-based structural information in coherent tomography (OCT) imaging. Herein we systematically analyzed under- and over-estimation bias of existing depth-resolved methods when applied to real biological tissues, then proposed new algorithm remedies these issues accommodates general OCT data contain incomplete decay noise floor, thereby affording consistent estimation accuracy for...