A5066041551- Environmental Toxicology and Ecotoxicology
- Pesticide Exposure and Toxicity
- Aluminum toxicity and tolerance in plants and animals
- Cholinesterase and Neurodegenerative Diseases
- Advanced biosensing and bioanalysis techniques
- Paraoxonase enzyme and polymorphisms
- Plant Micronutrient Interactions and Effects
- Graphene and Nanomaterials Applications
- Cardiac Ischemia and Reperfusion
- Dendrimers and Hyperbranched Polymers
- Respiratory and Cough-Related Research
- Essential Oils and Antimicrobial Activity
- Neuroscience and Neuropharmacology Research
- Arsenic contamination and mitigation
- Hibiscus Plant Research Studies
- Antimicrobial agents and applications
- Wound Healing and Treatments
- Carbon and Quantum Dots Applications
- Porphyrin and Phthalocyanine Chemistry
- Medical and Biological Ozone Research
- Sinusitis and nasal conditions
- Chemotherapy-induced organ toxicity mitigation
- Iron Metabolism and Disorders
- Microbial Metabolism and Applications
- Phytochemistry and Bioactivity Studies
Erzurum Technical University
2020-2025
Eskişehir Osmangazi University
2024-2025
Atatürk University
2018
Background/Objectives: Over the past 25 years, numerous biological molecules, like recombinant lysosomal enzymes, neurotrophins, receptors, and therapeutic antibodies, have been tested in clinical trials for neurological diseases. However, achieving significant success applications has remained elusive. A primary challenge inability of these molecules to traverse blood-brain barrier (BBB). Recognizing this hurdle, our study aimed utilize niosomes as delivery vehicles, leveraging "molecular...
Abstract The purpose of this study is to measure the effects acrylamide (AA) on bone marrow and blood protective efficacy boric acid (B) in rats. animals were divided into five groups: control, B, low-dose B + AA, high-dose AA. After 15 th day experiment, their harvested be kept for hematological analyses. While white cells (WBC) increased following administration bodyweight, red cells, platelets, hemoglobin, hematocrit, nucleated cell counts significantly decreased number. Conversely,...
In this study, changes in the blood tissue of rainbow trout (Oncorhynchus mykiss, Walbaum, 1792) caused by Fipronil (FP) insecticide were investigated using different biomarkers (Hematology parameters, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), malondialdehyde (MDA), paraoxonase (PON), arylesterase (ARE), myeleperoxidase (MPO), micronucleus (MN), 8-hydroxy-2-deoxyguanosine (8-OHdG)) level and caspase-3 activity. Statistically significant alterations hematology...
Recently, boron has been used in animal feeding due to its significant biological roles. In this study, the action mechanism of colemanite (COL), a commercially important borate mineral, was aimed investigate via evaluating parameters related oxidative alterations on brain, liver and blood tissues zebrafish. For purpose, zebrafish were exposed different doses COL (5, 10 20 mg/L) static test apparatus for 96 hours. Multiple biochemical analysis including determination DNA damage (8-OHdG),...
The search for an innovative and effective drug delivery system that can carry release targeted drugs with enhanced activity to treat Alzheimer's disease has received much attention in the last decade. In this study, we first designed a boron-based treatment of AD by integrating folic acid (FA) functional group into hexagonal boron nitride (hBN) nanoparticles (NPs) through esterification reaction. hBN-FA carrier was assembled new candidate novel hybrid containing antioxidant as BLA,...
We have discovered new anthracene derivatives with strong fluorescence properties in the visible region. They exhibit high binding affinities to microtubule proteins potential be used as fluorescent probes for imaging applications.
Complications of chronic non-healing wounds led to the emergence nanotechnology-based therapies enhance healing, facilitate tissue repair, and prevent wound-related complications like infections. Here, we design alpha lipoic acid (ALA) conjugated hexagonal boron nitride (hBN) carbide (B4C) nanoparticles (NPs) wound healing in human dermal fibroblast (HDFa) cell culture characterize its antimicrobial properties against Staphylococcus aureus (S. aureus, gram positive) Escherichia coli (E....
So far, there is no effective disease-modifying therapies for Alzheimer’s Disease (AD) in clinical practice. In this context, glycine-L-proline-L-glutamate (GPE) and its analogs may open the way developing a novel molecule treating neurodegenerative disorders, including AD. turn, study was aimed to investigate neuroprotective potentials exerted by three GPE peptidomimetics (GPE1, GPE2, GPE3) using an vitro AD model. Anti-Alzheimer were determined wide array of techniques, such as...
Nowadays, the unique features of nanoparticles (NPs) have encouraged new applications in different areas including biology, medicine, agriculture, and electronics. Their quick joining into daily life not only enhances uses NPs a wide range modern technologies but also their release aquatic environment causes inevitable environmental concerns. On other hand boron exhibits key physiological effects on biological systems. This research was designed for evaluating toxicity magnetite (Fe3O4-MNPs)...
Pyridine is a basic heterocyclic organic compound. The pyridine ring present in many important compounds, including agricultural chemicals, medicines and vitamins. Due to their widespread industrial use, bioaccumulation non-target toxic effects are being considered as great risk human environmental health. In this study, we aimed evaluate the hematological, oxidative genotoxic damage potentials by different concentrations (1, 1.5, 2 g/L) of ketone 3-Benzoylpyridine (3BP) on rainbow trout...
Age-related macular degeneration (AMD) is an eye disease that impairs the sharp and central vision need for daily activities. Recent advances in molecular biology research not only lead to a better understanding of genetics pathophysiology AMD but also development applications based on targeted gene expressions treat disease. Clarification pathways causing progression dry wet types needs comprehensive comparative investigations particular precious biopsies involving peripheral blood samples...
Aim: The aim of this study was to assess the nasal and olfactory functions patients with chronic obstructive pulmonary disease (COPD).Material Methods: This prospective included followed-up COPD in diseases clinic. Patients without any or systemic were study. After routine ear nose throat examination performed, no pathology had saccharin test Sniffin’ Sticks tests applied. control group consisted volunteers that living same region. applied too results compared.Results: There significant...
Acetyl ferrocene (AFC) is being used commonly in several industrial applications and scientific diciplines. Hence, this study we aimed to determine the LC50 value of AFC, evaluate toxicity potential by AFC exposure on rainbow trout (Oncorhynchus mykiss) for 96 h. We also focused investigate whether UX conferred a protection against AFC-induced toxic insults fish. For purpose, some stress related endpoints were measured blood liver tissues multibiomarker approach. The observed...
Propolis is the extract of a resinous compound that protects plants from both cold and microorganism attack has gained strong sticky property because it transformed after being collected by honey bees. Up to date, many studies have shown propolis exhibited various beneficial biological activities, such as antifungal, antibacterial, antiviral, antioxidant, antimutagenic, antitumor effects. Recent reports propounded in vitro vivo neuroprotective effect propolis; however, exact molecular...
Aluminum (Al), which has wide usage areas, is released into aquatic environments by natural processes and anthropogenic sources including coal strip mining activities, water treatment facilities using aluminum hydroxide (AH) as a coagulant for suspended solid particles, industrial wastes acid rainfall. With the acidification of surface waters, Al able to pass organisms provoke toxicity in fish. On other hand, several boron compounds such borax (BX) boric (BA) are great interest protective...
Nanobiotechnology influences many different areas, including the medical, food, energy, clothing, and cosmetics industries. Considering wide usage of nanomaterials, it is necessary to investigate toxicity potentials specific nanosized molecules. Boron-containing nanoparticles (NPs) are attracting much interest from scientists due their unique physicochemical properties. However, there limited information concerning boron-containing NPs, cobalt boride (Co2B) NPs. Therefore, in this study,...