A5041863940- Chemotherapy-induced organ toxicity mitigation
- Selenium in Biological Systems
- Heavy Metal Exposure and Toxicity
- Antioxidant Activity and Oxidative Stress
- Aluminum toxicity and tolerance in plants and animals
- Marine and environmental studies
- Liver physiology and pathology
- Drug-Induced Hepatotoxicity and Protection
- Paraoxonase enzyme and polymorphisms
- Pesticide Exposure and Toxicity
- Potato Plant Research
- Dialysis and Renal Disease Management
- Cassava research and cyanide
- Natural Antidiabetic Agents Studies
- Animal Nutrition and Physiology
- Coenzyme Q10 studies and effects
- Child Nutrition and Water Access
- Phytochemicals and Antioxidant Activities
- Nigella sativa pharmacological applications
- Pregnancy and Medication Impact
- Plant Micronutrient Interactions and Effects
- Curcumin's Biomedical Applications
- Vitamin C and Antioxidants Research
- Magnesium in Health and Disease
- Sesame and Sesamin Research
Kırıkkale University
2016-2025
Eskişehir Osmangazi University
2004-2016
This study aimed to explore the effective utilization of clarithromycin (CLA) through development clarithromycin-loaded solid lipid nanoparticles (CLA-loaded SLN), designed for nebulizer-based delivery first time. Wistar albino rats were divided into seven groups (n=8) based on time points (0.5, 1, 2, 4, 12, 24 hours, and a control group). At respective points, lung tissues blood samples collected analyzed CLA concentrations using HPLC-MS/MS. The maximum serum concentration (Cmax) was 6.74...
Aim of this study is to detect the protective role selenium (Se) against bone marrow and blood toxicity in CP-induced hematoxicity model. We categorized rats into 6 groups 7 animals each group (control; 150 mg/kg CP; 0.5 Se; 1 150+0.5 CP+Se; 150+1 CP+Se). Se injections started 5 days before CP carried on until end experiment (6 th day) for which was injected together with Se. applied as a single dose anesthesia. For that reason, day, taken cardiac puncture by flushing femur. Peripheral cells...
ÖZET: Siklofosfamid (CP)'in antitümör etkinliği dozu ile doğru orantılıdır.Bununla birlikte, yüksek dozlarda yaygın sitotoksisitelere neden olur.Selenyum (Se) yapısına katıldığı glutatyon peroksidaz gibi selenoproteinler yoluyla potansiyel besinsel bir antioksidan olarak biyolojik etkiler göstermektedir.Bu nedenle siklofosfamid nedenli hepatotoksisitede selenyumun olası koruyucu etkisinin araştırılması amaçlanmıştır.Toplam 42 adet erkek Spraque-Dawley sıçan 6 gruba (n=7) ayrıldı (kontrol,...
Ulcerative colitis is known to cause damage the liver tissue. Although synthetic and natural substances have been used prevent in colitis, little success has achieved so far. In this study rats were given 120 mg/kg of trinitrobenzene sulfonic acid (TNBS) order induce colitis. Protective effects lycopene N-Nitro-LArginine Methyl Ester (L-NAME) on oxidative stress assessed. 91 male Sprague Dawley study. These divided into 12 groups, each consisting 7 rats, apart from control group. 1ml saline...
Bor (B) ve Selenyum (Se), antioksidan, anti-apoptotik, anti-lipid peroksidatif bağışıklık güçlendirici özellikleri sayesinde insan vücudu için gerekli eser elementlerdir. Bu çalışma, Se B'nin Siklofosfamid (SFD) ile indüklenen kemik iliğinde miyeloid koruyucu potansiyellerini bu anti-kanser ilacın miyelotoksik özelliğinin kullanımını sınırladığını göz önünde bulundurarak deneysel sıçanlarda hematolojik toksisiteyi karşılaştırmayı amaçlamaktadır. SFD'nin iliği kan hücreleri üzerindeki toksik...
Tuberculosis continues to be an important health problem in the world. Besides pulmonary involvement extrapulmonary becomes affair developing countries, even developed countries.A thirty-six year old male patient was admitted with abdominal pain, diarrhea, nausea, vomiting and fever which had started one week before. The been followed up predialisis Chronic Renal Failure(CRF) diagnosis for 4 years receiving continuous ambulatory peritoneal dialysis (CAPD) treatment months. In fluid, 1600/mm3...
Bu çalışmada streptozotosin ile indüklenen diyabetik sıçanlarda Curcuma longa, Nigella sativa, Prunus mahaleb ve Vitis vinifera çekirdeğinden oluşan poliherbal ekstraktının metforminin; periferik kan, kemik iliği antioksidan parametreler üzerine etkisi araştırıldı. 60 adet wistar cinsi albino sıçanlar; kontrol, STZ, STZ + MET, PH I (500 mg/kg) II (1000 şeklinde 5 gruba ayrıldı. Hemoglobin, hematokrit, eritrosit, lökosit trombosit değerlerinde, STZ’de kontrol’e kıyasla yaklaşık %12-20 azalma,...
Abstract Treatment options to improve overall survival rate of prostate cancer patients are limited since tumor cells acquire resistance the chemotherapeutic drugs. We aimed determine anticancer effects stone alkaline water (SAW) on PC-3 and DU-145 adenocarcinoma cell lines. SAW was obtained by triturating high stones under vacuum at 3000 °C. High mineral trace element containing fraction used for experiments. Viability analyzed using tetrazolium based WST-1 proliferation assay, cycle...
The present study aims to investigate hematoprotective and antioxidant effects of Salvia virgata (SV) on Cyclophosphamide (CP)-induced toxicity. rats were divided into 6 groups 7 members each. These the Control group, CP Group (150 mg kg-1), 100 200 kg-1 SV Groups, CP+100 CP+200 Groups. All sacrificed harvest their blood bone marrow samples day after final injections. While some used for leukocyte platelet count, others determine levels total capacity (TAC), malondialdehyde (MDA), oxidant...