A5033117855- Anesthesia and Sedative Agents
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Advanced Fluorescence Microscopy Techniques
- Neuroscience and Neuropharmacology Research
- Cell Image Analysis Techniques
- Anesthesia and Neurotoxicity Research
- Thermoregulation and physiological responses
- Optical Imaging and Spectroscopy Techniques
- Single-cell and spatial transcriptomics
Heidelberg University
2019-2023
University Hospital Heidelberg
2019-2023
Spreading depolarizations (SD) are characterized by breakdown of transmembrane ion gradients and excitotoxicity. Experimentally, N-methyl-D-aspartate receptor (NMDAR) antagonists block a majority SDs. In many hospitals, the NMDAR antagonist s-ketamine GABAA agonist midazolam represent current second-line combination treatment to sedate patients with devastating cerebral injuries. A pressing clinical question is whether this option should become first-line in sedation-requiring individuals...
Glioblastoma is the most common malignant primary brain tumor with poor overall survival. Magnetic resonance imaging (MRI) main modality for glioblastoma but has inherent shortcomings. The molecular and cellular basis of MR signals incompletely understood. We established a ground truth-based image analysis platform to coregister MRI light sheet microscopy (LSM) data each other an anatomic reference atlas quantification 20 predefined subregions. Our pipeline also includes segmentation...