A5003351212- Cardiac Ischemia and Reperfusion
- Mitochondrial Function and Pathology
- Heart Rate Variability and Autonomic Control
- Adipose Tissue and Metabolism
- Cardiac Arrest and Resuscitation
- Anesthesia and Neurotoxicity Research
- Ion channel regulation and function
- Cardiac electrophysiology and arrhythmias
- Nitric Oxide and Endothelin Effects
- Muscle Physiology and Disorders
- Spaceflight effects on biology
- Non-Invasive Vital Sign Monitoring
- Exercise and Physiological Responses
- Cardiovascular Function and Risk Factors
- Ion Channels and Receptors
- Cardiovascular Health and Disease Prevention
- Medical and Biological Ozone Research
- Neuroscience and Neuropharmacology Research
- Respiratory Support and Mechanisms
- Mechanical Circulatory Support Devices
- Sepsis Diagnosis and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Aortic Disease and Treatment Approaches
- Cardiovascular and exercise physiology
- Phonocardiography and Auscultation Techniques
Mount Sinai Medical Center
2015-2024
New York Institute of Technology
2020
University of California, Davis
2020
St James's University Hospital
2020
University of Leeds
2020
The Ark
2013-2019
Mount Sinai Hospital
2008-2015
McGowan Institute for Regenerative Medicine
2000-2004
University of Pittsburgh
2000-2003
Abstract Mutations in the type 1 ryanodine receptor (RyR1), a Ca 2+ release channel skeletal muscle, hyperactivate to cause malignant hyperthermia (MH) and are implicated severe heat stroke. Dantrolene, only approved drug for MH, has disadvantages of having very poor water solubility long plasma half-life. We show here that an oxolinic acid-derivative RyR1-selective inhibitor, 6,7-(methylenedioxy)-1-octyl-4-quinolone-3-carboxylic acid (Compound 1, Cpd1), effectively prevents treats MH stroke...
The earliest signaling pathways responsible for initiating the systemic response to hemorrhagic shock (HS) remain poorly characterized. We have investigated involvement of mitogen-activated protein (MAP) kinase C-JUN N-terminal (JNK) and its activation in liver as an early tissue hypoxia soon after initiation hemorrhage. In present studies, hemorrhage mice 25 mmHg 30 min resulted a significant (2.1-fold) increase JNK phosphorylation within liver. Results were similar rats hemorrhaged 40 1 h....
Neuronal intracellular Ca2+ homeostasis is critical to the normal physiological functions of neurons and neuronal dyshomeostasis has been associated with age related decline cognitive functions. Accumulated evidence indicates that underlying mechanism for this abnormal levels stimulate dysregulation signaling, which subsequently induces cell death. We examined in cortical (in vivo) hippocampal vitro) from young (3-mos), middle-age (12-mos), aged (24-mos) wild type C57BL6J mice. found a...
Background: Postoperative cognitive dysfunction (POCD) is a common disorder after general anesthesia in elderly patients, the precise mechanisms of which remain unclear. Methods: We investigated effect isoflurane with or without dantrolene pretreatment on intracellular calcium concentration ([Ca2+]i), reactive oxygen species (ROS) production, cellular lactate dehydrogenase (LDH) leak, calpain activity, and function using Morris water maze test young (3 months), middle-aged (12–13 aged (24–25...
Diabetic cardiomyopathy (DCM) is a primary disease in diabetic patients characterized by diastolic dysfunction leading to heart failure and death. Unfortunately, even tight glycemic control has not been effective its prevention. We have found aberrant Ca2+ concentrations ([Ca2+]d), decreased glucose transport, elevated production of reactive oxygen species (ROS), increased calpain activity cardiomyocytes from murine model (db/db) type 2 diabetes (T2D). Cardiomyocytes these mice demonstrate...
Low-amplitude pulses to the vasculature increase pulsatile shear stress endothelium. This activates endothelial nitric oxide (NO) synthase (eNOS) promote NO release and endothelial-dependent vasodilatation. Descent of dicrotic notch on arterial pulse waveform a-to-b ratio (a/b; where a is height amplitude b above end-diastolic level) reflects vasodilator (increased a/b) vasoconstrictor effects (decreased due level change. Periodic acceleration (pG(z)) (motion supine body head foot platform)...
The recognition that oxidative stress is a major component of several chronic diseases has engendered numerous trials antioxidant therapies with minimal or no direct benefits. Nanomolar quantities nitric oxide released into the circulation by pharmacologic stimulation eNOS have properties but physiologic as through increased pulsatile shear endothelium not been assessed. present study utilized non-invasive technology, periodic acceleration (pGz) increases such upregulation cardiac occurs, We...
Duchenne muscular dystrophy (DMD) is an irreversible and severe muscle wasting X-linked genetic disease characterized by a progressive loss of function, decreased ambulation, ultimately death as result cardiac or respiratory failure. DMD caused the lack dystrophin, protein that important for membrane stability signaling in excitable cells. Although vascular smooth cells (VSMCs) dysfunction occurs many pathological conditions, little known about function DMD. We have previously shown striated...
Skeletal muscle is the primary site of insulin-mediated glucose uptake through body and, therefore, an essential contributor to homeostasis maintenance. We have recently provided evidence that chronic elevated intracellular Ca2+ concentration at rest [(Ca2+)i] compromises in malignant hyperthermia cells. To further investigate how [Ca2+]i modifies homeostasis, we measured and vivo vitro intact polarized cells from glucose-intolerant RYR1-p.R163C db/db mice. Glucose-intolerant mice...
Malignant hyperthermia (MH) is a genetic disorder triggered by depolarizing muscle relaxants or halogenated inhalational anesthetics in genetically predisposed individuals who have chronic elevated intracellular Ca
Myocardial infarction (MI) may produce significant inflammatory changes and adverse ventricular remodeling leading to heart failure premature death. Pharmacologic, stem cell transplantation, exercise have not halted the inexorable rise in prevalence great economic costs of despite extensive investigations such treatments. New therapeutic modalities are needed. Whole Body Periodic Acceleration (pGz) is a non-invasive technology that increases pulsatile shear stress endothelium thereby...
Continuous flow ventricular assist devices (CFVADs) are thought to be the next generation of circulatory devices. With many now in various stages development or clinical trial, it is important that physiologic aspects these pumps critically analyzed. In this study, 15 calves were divided into two groups. One group received a CFVAD, and other sham implant. Two additional animals used an acute study examine aortic blood patterns from CFVAD. Tissue perfusion was measured on all before surgery...