A5079745226- Advanced Proteomics Techniques and Applications
- Advanced Glycation End Products research
- Metabolomics and Mass Spectrometry Studies
- Scientific Computing and Data Management
- Genomics and Phylogenetic Studies
- Mass Spectrometry Techniques and Applications
- Natural Antidiabetic Agents Studies
- Protein Hydrolysis and Bioactive Peptides
ActionAid
2024-2025
Helmholtz Zentrum München
2021-2022
Leibniz-Institute for Food Systems Biology at the Technical University of Munich
2021-2022
The exponential increase in proteomics data presents critical challenges for conventional processing workflows. These pipelines often consist of fragmented software packages, glued together using complex in-house scripts or error-prone manual workflows running on local hardware, which are costly to maintain and scale. MSAID Platform offers a fully automated, managed pipeline, consolidating formerly disjointed functions into unified, API-driven services that cover the entire process from raw...
Abstract Proteomic workflows generate vastly complex peptide mixtures that are analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS), creating thousands of spectra, most which chimeric and contain fragment ions from more than one peptide. Because differences in data acquisition strategies such as data-dependent (DDA), data-independent (DIA) or parallel reaction monitoring (PRM), separate software packages employing different analysis concepts used for identification...
Identification of chemically modified peptides in mass spectrometry (MS)-based glycation studies is a crucial yet challenging task. There need to establish mode for matching tandem (MS/MS) data, allowing both known and unknown peptide modifications. We present an open search approach that uses classic fragment ions. The latter are shifted by the delta modification. Both provide key structural information can be used assess core structure product. also leverage redundant neutral losses from...
Peptide glycation is an important, yet poorly understood reaction not only found in food but also biological systems. The enormous heterogeneity of peptides and the complexity reactions impeded large-scale analysis peptide derived products to understand both contributing factors how this affects activity peptides. Analyzing time-resolved Amadori product formation, we here explored site-specific for 264 Intensity profiling together with in-depth computational sequence deconvolution resolved...