Jason Reier
A5033199843- Monoclonal and Polyclonal Antibodies Research
- Protein purification and stability
- Viral Infectious Diseases and Gene Expression in Insects
- RNA and protein synthesis mechanisms
- CAR-T cell therapy research
- Biomedical and Engineering Education
- Biomedical Ethics and Regulation
- Bacterial Genetics and Biotechnology
AstraZeneca (United States)
2019-2023
Bioengineering Center
2017
National Center for Genetic Engineering and Biotechnology
2017
John Wiley & Sons (United States)
2017
Hudson Institute
2017
The ability to genetically encode non-natural amino acids (nnAAs) into proteins offers an expanded tool set for protein engineering. nnAAs containing unique functional moieties have enabled the study of post-translational modifications, interactions, and folding. In addition, been developed that enable a variety biorthogonal conjugation chemistries allow precise efficient conjugations. These are being studied create next generation antibody-drug conjugates with improved efficacy, potency,...
Abstract The global COVID‐19 pandemic ignited an unprecedented race to develop vaccines and antibody therapeutics. AstraZeneca's pursuit provide AZD7442 (EVUSHELD), two long‐acting, SARS‐CoV‐2 spike receptor binding domain‐specific neutralizing monoclonal antibodies, individuals at risk on highly accelerated timelines challenged our traditional ways of process development spurred the rapid adoption novel approaches. Conventional upstream processes were replaced by agile strategies that...
Coagulation factor II (prothrombin; FII) is the pre-proteolyzed precursor to thrombin in coagulation cascade. It has 10 sites of gamma-carboxylation, which are required for its bioactivity, and N-glycosylated at three four putative sites. Production recombinant human FII (rhFII) using a platform fed-batch process designed monoclonal antibody production resulted low levels gamma-carboxylation sialylation. There have not been any prior reports successful development clinical manufacture rhFII...
US$15500 (US and Rest of World), € 10001(Europe), £ 7911 (UK