A5024740002- Cancer Diagnosis and Treatment
- Cancer Cells and Metastasis
- Melanoma and MAPK Pathways
- Cutaneous Melanoma Detection and Management
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Reconstructive Surgery and Microvascular Techniques
- Cancer Genomics and Diagnostics
- Cutaneous lymphoproliferative disorders research
- Aortic aneurysm repair treatments
- Lung Cancer Treatments and Mutations
- Metastasis and carcinoma case studies
- Advanced Breast Cancer Therapies
- Radiomics and Machine Learning in Medical Imaging
- Breast Cancer Treatment Studies
- Liver physiology and pathology
- Nonmelanoma Skin Cancer Studies
- S100 Proteins and Annexins
- Multiple and Secondary Primary Cancers
- Ocular Oncology and Treatments
- Cancer Research and Treatments
- Vitamin D Research Studies
- Organ Transplantation Techniques and Outcomes
- Medical Imaging Techniques and Applications
- Single-cell and spatial transcriptomics
Charles University
2011-2025
University Hospital Plzen
2023
Pilsen Tools (Czechia)
2021
An en bloc orbitectomy is one of the most invasive surgical procedures in orbit, primarily used to remove advanced malignancies, ensure negative resection margins, and local cancer control. This study examines indications, clinical features, outcomes, survival rates patients who underwent this surgery for periocular orbital malignancies. A retrospective consecutive case series seven with various carcinomas managed from 2018-2023 at University Hospital Pilsen, Czech Republic, was conducted....
Implementation of adjuvant therapies in non-metastatic melanoma improved treatment outcomes some patients; however, therapy can be associated with significant cost and risk toxicity. Therefore, there is an unmet need to better identify patients at high recurrence.We carried out ultrasensitive droplet digital PCR (ddPCR)-based detection BRAFV600E-mutated circulating tumor DNA (ctDNA) from blood samples prospectively collected before surgery, 1 hour after then serially during follow-up.In 80...
Background/Aim: Non-invasive circulating tumor biomarkers in liquid biopsy, such as microRNAs (miRNA), provide for better personalization of treatment strategies. The aim our study was to assess the prognosis patients with melanoma undergoing resection curative intent based on analysis selected miRNAs. Patients and Methods: A total 22 stage I III were enrolled into this prospective study. Plasma samples obtained pre-surgery early post-surgery from peripheral blood draws. panel 23 candidate...
Two unusual Carney complex patients are described. In one of them, several cutaneous biopsies revealed myxoid lesions that were rather more close to authentic adnexal neoplasms with stroma than a "myxoma an epithelial component." These included resembling trichofolliculoma, infundibular cyst, and trichodiscoma. Additionally, 1 soft tissue myxoma was unique in the sense it greatly resembled cardiac myxoma, begging question whether this could represent embolus from patient's myxoma. Given...
Due to different biological characteristics of non-colorectal liver metastasizes (NCLM), surgical treatment, especially it´s long term results, is a topic discussion. The aim the study was evaluate single center experience with treatment NCLM.Seventy two patients were prospectively included. average length time after primary surgery 3.9 years (0-8.5 years). RFA prevailed -50 (69.4%), resection presenting 30.6%. Preoperative chemotherapeutical downstaging or portal vein embolization performed...
Melanoma represents one of the most aggressive forms cancer. With rapid increases in incidence melanoma United States, Australia and Europe over last decades, has been considered an epidemic cancer these areas. The aim our study was to evaluate utility osteoprotegerin (OPG), osteopontin (OPN), epidermal growth factor (EGF) vascular endothelial VEGF for diagnosis prognosis melanoma.Overall, 322 individuals were assessed: 183 patients 139 healthy individuals. divided into four subgroups...
Abstract Rationale: Testosterone is important for the development of secondary sexual characteristics in female-to-male transsexuals. On contrary, it can increase risk breast cancer. Patient concerns: We present a rare case cancer transsexual patient after long-term hormonal therapy. Diagnosis: Breast patient. Interventions: The underwent mastectomy and chemotherapy. Outcomes: had local recurrence disease he re-excision, radiotherapy tamoxifen treatment. After this treatment, remission from...
We report on a 2.5-month-old infant with ischemia of the left leg and compartment following intraosseous needle application during resuscitation. Unfortunately, this event led to major limb amputation. The cause, mechanism, prevention severe complication are discussed in article.
Background: Portal vein embolization (PVE) and PVE with autologous mesenchymal stem cell application (PVE–MSC) increases future liver remnant volume (FLRV). The aim of this study was to compare both methods from the aspect FLRV growth, progression colorectal metastases (CLM), CLM resectability long-term results. Patients Methods: Fifty-five patients insufficient were included in study. FLVR growth evaluated using computed tomography. Liver resection performed >30% total volume. Results:...
The results of surgical treatment breast cancer liver metastases (BCLM) remain suboptimal. search for perioperative prognostic factors could help determine high risk groups patients. aim study was to evaluate the significance tumour markers (TM) on long-term results.Liver surgery carried out in 32 women BCLM. serum levels CEA, CA19-9, TPA, TPS, CYFRA 21-1 and TK were determined.Preoperative CA19-9 significant overall survival (OS)(p<0.05) recurrence-free (RFS) (p<0.01). TPS OS (p<0.05;...
Nail bed reconstruction is crucial after fingertip trauma, impacting both function and aesthetics. In this article, the authors describe a case of partial distal phalanx amputation index finger with laceration nail bed’s remaining part. A traumatically elevated skin-fat flap covered exposed bone on fingertip, preserving length sensitivity radial side. full-thickness skin graft from forearm closed secondary defect pulp. suturing prevented scarring deformity, temporary artificial plastic...
Melanoma is the most aggressive skin cancer with ability to recur also after early-stage tumor surgery. The aim was identify melanoma patients at high risk of recurrence using liquid biopsy, estimating mutated BRAF ctDNA and level marker S100B in plasma.