Michaela C. Pletsch

ORCID: 0000-0003-1440-0614
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About
Contact & Profiles
Research Areas
  • SARS-CoV-2 and COVID-19 Research
  • COVID-19 Clinical Research Studies
  • COVID-19 epidemiological studies
  • Biomarkers in Disease Mechanisms
  • Cholangiocarcinoma and Gallbladder Cancer Studies
  • COVID-19 Impact on Reproduction
  • Cardiovascular, Neuropeptides, and Oxidative Stress Research
  • Peptidase Inhibition and Analysis
  • Cancer, Stress, Anesthesia, and Immune Response
  • Heart Rate Variability and Autonomic Control
  • Cardiac Imaging and Diagnostics
  • Liver Diseases and Immunity
  • Lung Cancer Diagnosis and Treatment
  • Radiopharmaceutical Chemistry and Applications
  • Acute Myocardial Infarction Research
  • Cardiovascular and exercise physiology

Western University of Health Sciences
2023

Mayo Clinic
2021

WinnMed
2020-2021

Mayo Clinic in Arizona
2021

The United States (US) Expanded Access Program (EAP) to coronavirus disease 2019 (COVID-19) convalescent plasma was initiated in response the rapid spread of severe acute respiratory syndrome 2 (SARS-CoV-2), causative agent COVID-19. While randomized clinical trials were various stages development and enrollment, there an urgent need for widespread access potential therapeutic agents. objective this study is report on demographic, geographical, chronological characteristics patients EAP, key...

10.1371/journal.pmed.1003872 article EN public-domain PLoS Medicine 2021-12-20

Abstract Successful therapeutics and vaccines for coronavirus disease 2019 (COVID-19) have harnessed the immune response to severe acute respiratory syndrome 2 (SARS-CoV-2). Evidence that SARS-CoV-2 exists as locally evolving variants suggests immunological differences may impact effectiveness of antibody-based treatments such convalescent plasma vaccines. Considering near-sourced likely reflects antigenic composition local viral strains, we hypothesize has a higher efficacy, defined by...

10.1038/s41467-021-25113-5 article EN cc-by Nature Communications 2021-08-11

Abstract Successful therapeutics and vaccines for coronavirus disease 2019 (COVID-19) have harnessed the immune response to severe acute respiratory syndrome 2 (SARS-CoV-2). Evidence that SARS-CoV-2 exists as locally evolving variants suggests immunological differences may impact effectiveness of antibody-based treatments such convalescent plasma vaccines. Considering near-sourced is likely reflect antigenic composition local viral strains, we hypothesized has a higher efficacy, defined by...

10.1101/2021.03.19.21253975 preprint EN medRxiv (Cold Spring Harbor Laboratory) 2021-03-22

Background Sympathetic nerve activity and its effect on blood pressure are altered by female sex hormones; however, this differs between exogenous endogenous hormones. With oral contraceptive (OC) use, cross‐sectional data has demonstrated higher (BP) with no corresponding change in muscle sympathetic (MSNA). This results a BP/MSNA ratio OC use although contributing mechanisms unclear. The women suggests may limit the ability of baroreflex (sBRS) to suppress MSNA. Alternatively, “burst” MSNA...

10.1096/fasebj.2020.34.s1.05875 article EN The FASEB Journal 2020-04-01
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