A5064134221- Trypanosoma species research and implications
- Insect symbiosis and bacterial influences
- Research on Leishmaniasis Studies
- CRISPR and Genetic Engineering
- Toxin Mechanisms and Immunotoxins
- Complement system in diseases
- Glycosylation and Glycoproteins Research
- Galectins and Cancer Biology
- Mosquito-borne diseases and control
Ludwig-Maximilians-Universität München
2019-2025
University of Edinburgh
2017-2024
Centre for Immunity, Infection and Evolution
2017
Trypanosoma brucei, the agents of African trypanosomiasis, undergo density-dependent differentiation in mammalian bloodstream to prepare for transmission by tsetse flies. This involves generation cell-cycle arrested, quiescent, stumpy forms from proliferative slender forms. The signalling pathway responsible quorum sensing response has been catalogued using a genome-wide selective screen, providing compendium protein kinases phosphatases, RNA binding proteins and hypothetical proteins....
Abstract Antigenic variation is an immune evasion strategy used by many different pathogens. It involves the periodic, non-random switch in expression of antigens throughout infection. How observed hierarchy antigen achieved has remained a mystery. A key challenge uncovering this process been inability to track transcriptome changes and potential genomic rearrangements individual cells during event. Here, we report establishment highly sensitive single-cell RNA-seq (scRNA-seq) approach for...
Abstract Antigenic variation is an immune evasion strategy used by many different pathogens. It involves the periodic, non-random switch in expression of antigens throughout infection. How observed hierarchy antigen achieved has remained a mystery 1,2 . A key challenge uncovering this process been inability to track transcriptome changes and potential genomic rearrangements individual cells during event. Here we report establishment highly sensitive single-cell RNA sequencing approach for...
Adaptation to a change of environment is an essential process for survival, in particular parasitic organisms exposed wide range hosts. Such adaptations include rapid control gene expression through the formation membraneless organelles composed poly-A RNA and proteins. The African trypanosome Trypanosoma brucei exquisitely sensitive well-defined environmental stimuli that trigger cellular differentiation events characterise its complex life cycle. parasite has been shown form stress...
African trypanosomes use an extreme form of antigenic variation to evade host immunity, involving the switching expressed variant surface glycoproteins by a stochastic and parasite-intrinsic process. Parasite development in mammalian is another feature infection dynamic, with undergoing quorum sensing (QS)-dependent differentiation between proliferative slender forms arrested, transmissible, stumpy forms. Longstanding experimental studies have suggested that frequency transmissibility may be...